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Enzymes working in reverse

Lyases are enzymes that catalyse the breaking of chemical bonds. Now, reversing this reaction towards carbon–nitrogen bond formation allows for the synthesis of various chiral aminocarboxylic acids such as the potential antibiotic co-drug aspergillomarasmine A.

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Fig. 1: EDDS-lyase-driven C–N bond breaking and formation.


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Correspondence to Romas J. Kazlauskas.

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Kazlauskas, R.J. Enzymes working in reverse. Nat Catal 1, 172–173 (2018).

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