Sensitive readout of implantable microsensors using a wireless system locked to an exceptional point

Abstract

Exceptional points are degeneracies in physical systems at which both the underlying eigenvalues and eigenvectors of the system coalesce. They originated in theoretical explorations of quantum mechanics, but are of increasing value in photonics, acoustics and electronics because their emergence in physical systems with controlled gain and loss can dramatically alter the response of a system. In particular, systems biased at exceptional points can exhibit an amplified response to a small perturbation, enabling greatly enhanced sensitivity for certain resonant sensors. In biomedicine, implanted electronic sensors based on resonant inductor–capacitor (LC) circuits can be used to monitor internal physiological states, but their capabilities are currently limited by the low sensitivity of existing wireless interrogation techniques. Here we show that a reconfigurable wireless system locked to an exceptional point can be used to interrogate in vivo microsensors with a sensitivity 3.2 times the limit encountered by existing schemes. We use a controller that maximizes the abruptness of a parity–time-symmetry phase transition to operate a reconfigurable circuit at an exceptional point and maintain enhanced sensitivity. With this approach, we demonstrate robust readout of LC microsensors (with diameters of 900 μm) that are subcutaneously implanted in a rat, and show that it can be used for wideband sensor interrogation for measurement of the resonant frequencies of single and multiple sensors.

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Fig. 1: Implantable microsensor readout with a wireless system locked to an exceptional point.
Fig. 2: Readout mechanism and sensitivity enhancement at an EP.
Fig. 3: Experimental demonstration of enhanced sensitivity by EP locking.
Fig. 4: Microsensor readout in physiological environments.
Fig. 5: Wideband interrogation of single and multiple sensors.

Data availability

The data that support the plots within this paper and other findings of this study are available from the corresponding author upon reasonable request.

Code availability

Pseudocode for the EP-locking algorithm is provided in the Supplementary Information.

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Acknowledgements

The authors thank A. Bansal, Z. Xiong and G. Gammad for their assistance with the in vivo experiments and Z. Goh for the art in Fig. 1. J.S.H. acknowledges support from the National Research Foundation Singapore (NRFF2017-07), Ministry of Education Singapore (MOE2016-T3-1-004), and Institute for Health Innovation and Technology grants.

Author information

J.S.H. and C.-W.Q. conceived and planned the research. Z.D. performed the simulations and designed the wireless system. Z.D., Z.L. and F.Y. characterized the system and performed the experiments. J.S.H. and Z.D. wrote the paper with input from all the authors.

Correspondence to John S. Ho.

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The authors declare no competing interests.

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Supplementary Information

Supplementary Notes A–F and Supplementary Figs. 1–11

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Dong, Z., Li, Z., Yang, F. et al. Sensitive readout of implantable microsensors using a wireless system locked to an exceptional point. Nat Electron 2, 335–342 (2019). https://doi.org/10.1038/s41928-019-0284-4

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