Table 1 LTRS/LVDS vs NP trajectory differences and effect sizes (Cohen’s d).

From: Using a Digital Neuro Signature to measure longitudinal individual-level change in Alzheimer’s disease: the Altoida large cohort study

Healthy LTRS/LVDS vs NP t Value p Value Cohen’s d 95% CI   MCI LTRS/LVDS vs NP t Value p Value Cohen’s d 95% CI   AD LTRS/LVDS vs NP t Value p Value Cohen’s d 95% CI  
M0–M6 10.37 0.009 1.1893 0.9438 1.4349 M0–M6 4.06 0.056 0.5742 0.2913 0.857 M0–M6 7.33 0.018 1.639 1.1325 2.1456
M6–M12 12.48 0.006 1.4411 1.1871 1.6951 M6–M12 9.67 0.011 1.3675 1.0597 1.6754 M6–M12 7.92 0.016 1.771 1.2539 2.288
M12–M18 12.50 0.006 1.4434 1.1893 1.6975 M12–M18 26.92 0.001 3.8071 3.3423 4.2718 M12–M18 7.25 0.018 1.6211 1.116 2.1263
M18–M24 13.82 0.005 1.5958 1.3359 1.8556 M18–M24 11.52 0.007 1.6292 1.3093 1.949 M18–M24 36.20 0.001 8.0946 6.766 9.4232
M24–M30 28.17 0.001 3.2528 2.9079 3.5977 M24–M30 11.23 0.008 1.5882 1.2703 1.906 M24–M30 12.85 0.006 2.8733 2.2486 3.4981
M30–M36 22.77 0.002 2.6293 2.3203 2.9383 M30–M36 18.86 0.003 2.6672 2.2862 3.0482 M30–M36 11.40 0.008 2.5491 1.9591 3.1391
M36–M40 17.71 0.003 2.045 1.7657 2.3242 M36–M40 17.46 0.003 2.4692 2.1013 2.8372 M36–M40 15.41 0.004 3.4458 2.755 4.1365