Familial hypercholesterolemia (FH) is an underdiagnosed dominant genetic condition affecting approximately 0.4% of the population and has up to a 20-fold increased risk of coronary artery disease if untreated. Simple screening strategies have false positive rates greater than 95%. As part of the FH Foundation′s FIND FH initiative, we developed a classifier to identify potential FH patients using electronic health record (EHR) data at Stanford Health Care. We trained a random forest classifier using data from known patients (n = 197) and matched non-cases (n = 6590). Our classifier obtained a positive predictive value (PPV) of 0.88 and sensitivity of 0.75 on a held-out test-set. We evaluated the accuracy of the classifier′s predictions by chart review of 100 patients at risk of FH not included in the original dataset. The classifier correctly flagged 84% of patients at the highest probability threshold, with decreasing performance as the threshold lowers. In external validation on 466 FH patients (236 with genetically proven FH) and 5000 matched non-cases from the Geisinger Healthcare System our FH classifier achieved a PPV of 0.85. Our EHR-derived FH classifier is effective in finding candidate patients for further FH screening. Such machine learning guided strategies can lead to effective identification of the highest risk patients for enhanced management strategies.
Familial hypercholesterolemia (FH) is an autosomal dominant condition with an estimated prevalence of approximately 1 in 250,1 making it the among the most common morbid monogenic disorders. Lifelong elevation of low-density lipoprotein cholesterol (LDL-C) in individuals with FH cause up to a 20-fold excess risk of atherosclerotic cardiovascular disease (ASCVD) versus those with normal LDL-C levels.2,3 Importantly, the risk of ASCVD can be largely ameliorated through early identification and treatment with lipid-lowering therapies.1,4,5,6 In addition, because FH is highly penetrant, once an individual with FH is identified, cascade screening of relatives has been shown to be highly cost-effective in reducing excess morbidity in family members.2,6,7,8 The importance of differentiating FH from other causes of high LDL-C is reflected by guidelines from multiple national and international organizations, with FH-specific recommendations covering diagnosis, treatment and cascade screening.1,5,6
Despite the morbidity and mortality associated with FH and the clear benefits of timely management, it is estimated that less than 10% of persons with FH in the US have been diagnosed,1 with the identification of index FH cases (probands) as a major bottleneck. Currently, guidelines recommend the application of diagnostic criteria (e.g., Dutch Lipid Clinic Network (DLCN) or Simon-Broome) in adults for which there is high clinical suspicion, which is usually based on untreated LDL-C values >190 mg/dl plus a positive family history of early onset ASCVD.1,5,6 However, there are significant limitations to this approach. For instance, this strategy is non-specific: While high LDL-C is a cardinal feature of FH, less than 5% of adults with an LDL-C > 190 mg/dl will be found to harbor a causal FH gene mutation.3 In addition, this strategy largely relies on the availability of untreated LDL-C values and adequate family history information, either/both of which are often unavailable to the healthcare provider.
We sought to develop a classifier that could prioritize individuals within a healthcare system to undergo further evaluation for FH, thereby enhancing the efficiency of case identification. Machine-learning algorithms can analyze large datasets and determine combinations of variables that consistently classify or predict a certain outcome.9 Such models have been widely applied in non-medical fields10 with nascent but promising use in medicine.11,12 Widespread adoption of EHRs has led to large collections of patient-level data being available for the development of such algorithms.
As part of the FH Foundation′s FIND (Flag, Identify, Network, Deliver) FH initiative, here we report the development and internal validation of a supervised machine-learning algorithm to identify probable FH cases based on EHR data from Stanford Health Care as well as the external validation on this classifier using EHR data from the Geisinger Healthcare System. The performance of the classifier, which achieves a PPV of >0.8 across two independent datasets, and the resulting reduction in testing cost as well as case-finding burden, suggests that application of this classifier could lead to increased efficacy of targeting these high-risk patients for enhanced evaluation and intervention.
Our classifier was built using both structured and unstructured EHR data from Stanford as described in the methods. We confirmed clinical utility at the local site via manual chart review of patients flagged by the classifier and validated at an independent site (Geisinger) with genetically confirmed FH cases (Fig. 1).
As described in the methods, we developed a random forest classifier13 due to their resistance to overfitting, model interpretability, and ranking of important features. To quantify the performance of the classifier, we used common information retrieval metrics,14 namely positive predictive value (or precision), sensitivity (or true positive rate), specificity (true negative rate) and F1 score (or F-Measure). Our classifier obtained a positive predictive value (PPV) of 0.88 and sensitivity of 0.75 (Fig. 1a and Table 1) on a held-out test-set. We also report the area under the receiver operator curve (AUROC) and the area under the precision-recall curve (AUPRC), which is more informative for low prevalence outcomes.15 We included F1 score and AUPRC as part of our evaluation metrics since the F1 score summarizes model performance at a specific probability threshold, in contrast, the AUPRC value summarize the performance of a model across all possible thresholds. Thus, F1 and AUPRC provide complementary information. In the supplementary materials, under Random Forest Classifier Error Analysis, we provide the classifier error analysis and AUROC and AUPRC plots for clarity.
Evaluation via chart review
The classifier outputs the probability of each patient being a case. Given the use case of the classifier—which is to drive screening and further evaluation of flagged patients—we selected 100 patient records held out from the training data from multiple bins of the classifier output ranging from probability 0.99–0.90, 0.89–0.80, 0.79–0.70, and 0.69–0.60 (Fig. 1b). We reviewed more charts from the high probability cases, and fewer of those that have a low chance of being a case to get the greatest granularity on the predictions in the probability group that is most likely to be put into practice.
Of the 56 predictions with a probability score of 0.99-0.90, 39 have a DLCN score of 3–5 (“possible” FH) and 5 of these would meet MEDPED criteria, 7 have a DLCN score of 6–8 (“probable” FH) and 3 of these would meet MEDPED criteria and 1 has a DLCN score > 8 (“definite” FH). In other words, 47/56 have a DLCN score of >=3 or are MEDPED positive (84%). In contrast: only 9/56 have a DLCN score of 1 or 2 (unlikely)(16%). As expected, the rate of likely cases diminishes in lower probability bins especially in those with a probability score < 0.7 (graphically represented in Fig. 2 and Supplementary Table 6).
We validated our classifier and its ability to detect FH patients by evaluating it on an independent dataset from Geisinger (Fig. 1c). This evaluation is performed by providing a set of 71 cases and 4970 controls to the Stanford classifier, ten times. We sample the 71 cases from the full set of 466 cases provided by Geisinger (see dataset details in Methods). Directly classifying the Geisinger dataset with its native 466:5000 case to non-case ratio would lead to overly optimistic estimates of performance.
Table 1 shows classifier performance in terms of the PPV, specificity, and sensitivity as well as the AUROC, AUPRC, and F1 score. As expected, there is a slight drop in PPV, AUROC, and AUPRC, given the different operational practices between institutions (coding, labs, clinical narratives). Limiting the analysis to just the genetically confirmed cases has an F1 score of 0.82. The results show that the classifier trained with Stanford data has good external validity in identifying FH patients at a different institution.
For completeness, we also built a classifier using Geisinger data (which had 0.88 PPV, 0.74 sensitivity, and 0.99 specificity) and tested its ability to classify Stanford patients. This classifier achieved a PPV of 0.83, sensitivity of 0.66 and specificity of 0.99.
Table 2 showcases the top 20 features used by the random forest to assign a probability score to each patient for having FH. These features are a vital part of the interpretability aspect of the random forest models as they can be traced for every patient assigned by the algorithm. The classifier uses a combination of laboratory tests, text mentions, diagnosis codes and prescriptions as the top features with many of them being related to cholesterol levels and hyperlipidemia diagnosis. The list includes text mentions about the disease (Lipid, Triglycerides) and possible lifestyle adjustments (Red Meat), demonstrating the importance of using statistical models on all the patient data available. One thing to note is that all the laboratory tests selected as informative features correspond to the high and very high bins created during feature engineering, which capture the higher than usual total cholesterol and LDL-C measurements.
The role of risk-stratification models and predictive algorithms to identify “high-risk” patients is well-established in clinical medicine. The 2013 American College of Cardiology/American Heart Association Omnibus calculator to identify non-FH patients who would benefit from statin initiation for primary prevention of ASCVD stands as a key example of a risk-stratification algorithm used in common practice.16
The advent of machine learning approaches presents an opportunity to leverage EHR data to develop risk-stratification and predictive models at scale.17 Notably, the ability of machine-learning algorithms to be trained on both structured and unstructured EHR data—such as free text—allows the use of variables that may not be considered in traditional settings. Machine-learning derived predictive models may be particularly suited to address care gaps for treatable conditions that have traditionally been underdiagnosed.
It is estimated that only ~10% of patients with FH are diagnosed in the United States.7 After an index case with FH is identified, cascade screening is highly effective in identifying affected family members. An initial diagnosis of FH generally involves the use of the MEDPED criteria, the UK Simon-Broome register criteria, and the DLCN criteria. These clinical criteria require manual imputation of certain variables: patient history including ASCVD events and pretreatment lipid levels, physical examination findings such as tendon xanthomas and arcus cornealis, family history details including LDL-C values of first-degree relatives, and results of patient genetic testing. The utility of these criteria is unclear given the real-world challenges in obtaining detailed family histories, low prevalence of variables such as physical exam findings like tendon xanthomas or elevated lipid levels and ASCVD events in relatives.18,19,20,21
Therefore, there is a strong need to develop better approaches to screen for FH. Given the widespread use of EHRs, a machine-learning based approach could increase the rate of index FH case identification at low cost. Indeed, among the patients flagged by our random forest classifier for whom chart review confirmed a likely diagnosis of FH, only 3 had been clinically diagnosed with FH. The formal diagnosis of FH should lead to a greater focus on effective management and more intensive therapy for LDL-C reduction. Although it is not required for diagnosis, genetic testing is a useful component of making a diagnosis of FH.22 Given the low prevalence of the condition, routine universal genetic testing of everyone with a high LDL-C is low yield and inefficient. However, knowledge of genetically defined subgroups within cohorts of clinically diagnosed FH cases is expected to ultimately drive differential management strategies, and thereby increase the value of genetic testing in this condition.
Recently, Safarova et al.23 described developing an automated process to score patients using the DLCN Criteria using both structured and unstructured EHR data. This process uses textual reports to determine the family history of having a first-degree relative with hypercholesterolemia or premature ASCVD, and to determine the presence of characteristics such as tendon xanthomas and corneal arcus. The quality of the text extraction is validated by reviewing 20 randomly selected charts to have sensitivity and specificity of 97 and 94%, with positive and negative predictive values at 94 and 97%, respectively. Subsequently, the natural language processing (NLP) extracted variables and other structured data elements are used to computationally “apply” the modified DLCN criteria to obtain a score.
Our effort has a fundamentally different approach. We learn a classifier that directly discriminates FH cases from non-cases without computing DLCN criteria as an intermediate. Of the cases our classifier flags, we evaluated them to be true or false based on several criteria, including genetic testing at an independent site. Our random forest classifier demonstrated good positive predictive value and sensitivity upon application to an unseen internal test dataset (ppv 0.88, sensitivity 0.75) and an external Geisinger EHR dataset (ppv 0.85, sensitivity 0.67) including those with genetically confirmed FH. These findings point to the external validity and overall potential utility of our EHR-based classifier to screen for patients with a high probability of FH. In a similar vein, Bastarache et al.24 have shown that it is possible to build phenotype risk score for identification of patients with underrecognized Mendelian disease patterns (though not for FH) by leveraging EHR data.
It is also natural to ask why not use “deep learning”. Given the small data size at hand and the chance for a deep neural network to overfit, coupled with the desire to have an interpretable model that would generalize across multiple sites, we used a simpler modeling approach.25,26
In summary, the use of a classifier to detect putative cases of FH from the EHR allows the identification of patients who have a substantial probability of having the condition. Clinicians can then perform targeted evaluation to confirm index FH cases, place referrals to appropriate subspecialty clinics for additional evaluation for FH, and eventually initiate therapy and cascade screening. Additionally, developing machine-learning algorithms may allow the identification of novel predictive variables. For instance, the top 20 predictive concepts in our random forest classifier include variables not used in the traditional FH clinical criteria, such as the diagnosis codes for paroxysmal supraventricular tachycardia and triglyceride levels (Table 2).
Our work has certain limitations. For the Stanford test dataset, we used an (estimated) FH prevalence of 1:70 in the test-set, if the real-life prevalence of FH cases in a lipid clinic is drastically different the classifier performance will differ. Measuring downstream outcomes such as the overall rates of FH diagnosis, cascade screening, ASCVD events or survival would require longitudinal observation after implementation of this algorithm and was not addressed in this study. While we have demonstrated that this classifier ported well to data from another health system, it is possible that we might see a performance increases if we used the data from both sites in order to train our classifier. We did not train using pooled data because doing so would not allow the assessment of external validity of the classifier. Finally, our sample of positive FH patients is relatively small (n = 197 at Stanford); and as with most machine learning approaches, having more training data would probably build a better classifier. We anticipate continuously refining our classifier as newly diagnosed cases accrue.
The ultimate utility of any screening test must be considered in the context of its cost-effectiveness. While we report multiple metrics of performance. In the current use case, due to the expense of manual chart review and follow on genetic testing, we aim for better PPV because it quantifies the frequency with which predictions are relevant or ‘worth following up′. If the cost of the follow-up action (chart review, and genetic testing) become negligible in the future, it would make sense to aim for higher recall at the expense of a lower PPV. For example, if FH occurs at a probability of 1 in 70 in a cardiology clinic with costs of $1000 to do genetic counseling and testing, and 15 min to apply the screening criteria, for each case found we would need to spend roughly $70,000 in genetic testing and 1050 min of clinician time. However, after applying EHR-based screening, the chance that an individual flagged by our algorithm has FH is 8 out of 10. As a result of this massive chance in post-test prevalence, the cost to find one new case drops to $1429 in genetic counseling and testing, and 21.4 min of clinician time. Therefore, compared to the implementation of universal genetic testing or clinical criteria-based screening, the economics of EHR-based detection of FH through machine-learning are extremely favorable and can massively improve the ability of a health system to find patients at risk. We believe the use of supervised learning to build a classifier that finds undiagnosed cases of FH is a compelling example of machine learning that matters.27 As a next step, we are working on deploying the model in a clinical setting, at Stanford Healthcare and at additional sites in partnership with the FH Foundation.
In conclusion, we have demonstrated that a supervised machine learning approach to building a classifier for finding patients that might have FH using EHR data is feasible with a positive predictive value of 0.88, sensitivity of 0.75 and specificity of 0.99. We validated our classifier by classifying 35,562 patients and reviewing predictions across a range of probability scores via chart review, and by applying established criteria, such as DLCN and MEDPED criteria, to determine the likelihood of the patients flagged by our classifier to have FH. We used unseen FH and non-FH patient data from the Geisinger Healthcare System to demonstrate external validity of the classifier. Compared to universal genetic testing or clinical criteria-based screening of all comers, the use of EHR-based detection of FH through machine-learning can massively improve the ability of a health system to find patients at risk of FH. Such case finding is particularly relevant because once a case is found, proven efficacious interventions already exist that can prevent catastrophic cardiovascular events; furthermore, that case can be used to ‘cascade′ to find multiple other cases within an extended family. Applied broadly, using our classifier to screen using EHRs could identify many thousands of the undiagnosed patients with FH and lead to more effective therapy and screening of their families.
Our classifier was built using both structured (e.g., labs, procedures, diagnostic codes) and unstructured (e.g., text from clinical notes and radiology reports) EHR data from Stanford and validated with data from an independent site (Geisinger) including a subset of genetically confirmed cases (Fig. 1). We perform our work using data in the OMOP common data model (OMOP-CDM). The building of the classifier is shown in Fig. 3.
A common data model and community tools
The Observational Health Data Sciences and Informatics (OHDSI) is a world-wide collaborative which features over 140 collaborators in 16 countries comprised of healthcare industry leaders, clinical researchers, computer scientists, and biostatisticians. OHDSI′s vision is to improve health by empowering a community to collaboratively generate evidence that promotes better health decisions and better care.28 The community has developed both a common data model (CDM), as well as a standard vocabulary for consistent representation of EHR data across sites. The CDM is comprised of 39 standardized tables that have gone through a refinement process over 5 iterations initially through the OMOP initiative.29 Approximately 84 sites have converted their local data into the common OHDSI CDM including both clinical and claims, totaling over 600 million patients. APHRODITE30 is an open source software package for building phenotype models using data in the OMOP CDM.
Dataset, Stanford Health Care
This dataset integrates patient data from Stanford Children′s Health (SCH) and Stanford Health Care (SHC) hospitals (Fig. 3). We used data from 3.1 million patients, which includes 70 million clinical notes including pathology, radiology and transcription reports, over 90 million coded diagnoses and procedures, 269 million laboratory tests and 59.3 million medication orders. From the clinical notes, we extracted over 7.8 billion clinical terms using a custom text processing workflow which recognizes present, non-negated mentions of terms from 22 clinically relevant ontologies (SNOMED, Human Disease Ontology, MedDRA among others). Each term is mapped to an UMLS CUIs while making sure that negative term mentions are flagged using NegEx regular expressions.31 More details about the text processing pipeline used can be found in ref. 32 The data are mapped to the OHDSI CDM version 5.0 using vocabulary v5.0 11-MAR-16. Newer versions might change the CDM structure, but the updates are backwards compatible. In addition, the Aphrodite package will be updated with CDM releases to make older phenotype models backwards compatible.
We used the APHRODITE, and other R packages designed by the OHDSI community, to extract all patient data, build patient feature matrices, and train machine learning models from the data. As features, we used the count of times a code, lab, drug prescription was found on the patient′s record. We normalized features by length of patient follow-up in years, removed features found in less than 10% patients, and excluded text mentions that are not medical terms. Finally, we binned the lab values for a given lab test in five discrete bins (very low, low, in-range, high, very high), which allowed us to handle extreme lab values that are characteristic of patients with potential FH. The bins are determined by acquiring the minimum and maximum values for each specific lab and then splitting the range in five equal bins.
To build our classifier, we used 197 known FH patients from Stanford (Figs. 1a and 3). The demographics tables for these cohorts are found in the Supplementary Appendix section (Supplementary Table 1). The FH patients were followed at an FH-specific clinic and had been diagnosed as probable or definite FH using existing diagnostic criteria including genetic testing information when available.5,33,34,35,36 The application of these criteria is done manually and takes upwards of 15–20 min of clinician time. Among these patients, the average pretreatment LDL-C was 258 mg/dl. Sixty-six were known to have a causal genetic variant in LDLR or APOB, 26 had undergone genetic testing that did not identify a causal mutation and 105 had not undergone genetic testing. There were no patients that were found to have causal PCSK9 variants. This is not unexpected as <1% of FH patients harbor causal mutations in PCSK9.
To ensure relevance of our classifier for use on patients at a higher risk for ASCVD for discerning between FH cases and similar non-FH cases “in the wild”,37,38 and to ensure that trivial classification (e.g., healthy 25-year olds classified as non-FH) does not produce optimistic results, we limited our non-cases (“controls”) to patients that: (1) had more than one visit at Stanford; (2) had at least one visit within the last 2 years; (3) had one comorbidity from the following: hypertension, coronary atherosclerosis (CAD), dyslipidemia, myocardial infarction. We also excluded patients with nephrotic syndrome, or obstructive (cholestatic) liver disease because both result in extremely elevated LDL-cholesterol levels for entirely different reasons and do not convey the same risk of coronary artery disease. Before training the classifier, we matched cases and controls by age, gender, and length of record, in order to avoid trivial classification. On applying these criteria, we had 35,562 patients as potential controls (Figs. 1a, b and 3).
Because the choices about disease prevalence affect classifier performance, it is important to develop the classifier for the specific scenario in which the classifier would be applied. While the population prevalence of FH is approximately 1 in 250 individuals, it is known to be more twice or three times as common in certain clinical settings such as in patients at high-risk of ASCVD or with hypercholesterolemia. In our case, we believe that this classifier would be most useful in flagging individuals within the healthcare system with an enhanced risk of ASCVD, we set a prevalence of 1:70 for evaluation, which is a reasonable estimate given the known prevalence of FH in individuals with hypercholesterolemia or increased risk of ASCVD (Supplementary Table 1).3
However, 1:70 is still a severe class imbalance for training a good classifier. Therefore, when training, we use a 1:30 prevalence, essentially upsampling the rare class (i.e., the positive cases) and downsampling the common class. Such upsampling (or downsampling) is a commonly used technique in machine learning with severe class imbalance.39 When evaluating the performance of the classifier, we use the 1:70 prevalence which is closest to the environment in which the classifier will be used.
From the total cases (n = 197) and controls (n = 35,562), we down-sampled the non-FH patients when training the classifier. We split the positive cases into test (n = 17) and training (n = 180) sets. From the potential controls (non-cases), we selected 5,400 random controls in the training set (setting 1:30 prevalence for the positive class) and selected 1190 for the test-set (setting a 1:70 prevalence for the positive class) (Fig. 2). We trained the classifier using 10-fold cross-validation, on the 1:30 prevalence training set, for parameter tuning. The best performing classifier from this process was tested on the unseen 17 cases and 1190 controls with 1:70 prevalence. We repeated the entire process 10 times (choosing different splits of the train/test sets). We selected the best performing classifier from these ten runs for evaluation by chart review and for external validation.
In previous work,40 we built and compared a logistic regression classifier with the random forest classifier. The overall performance was lower than the random forest, and in the current work, we only use the random forest classifier.
Evaluation via chart review
As shown in Fig. 1b, we applied the random forest classifier to held out patients from Stanford to flag potential FH cases, and evaluated the predictions with manual chart review. We randomly sampled 100 cases from those flagged by the classifier at different probability cutoffs. Our sample contained 56 patients with a probability of being an FH case between 0.99 and 0.90, 18 patients between 0.89 and 0.80, 16 between 0.79 and 0.70, and the remaining 10 from the probability ranges between 0.69 and 0.60 to perform a systematic chart review to assess the predictions at different thresholds. Patients were then scored using the DLCN or MEDPED criteria1,5 to determine the relationship between the machine-learning algorithm and these widely used clinical criteria, which are currently used to help inform choices about referral and clinical care. When evaluating the identified patients via chart review, individuals were judged to have FH if they met either DLCN or MEDPED criteria.
The DLCN criteria assigns points for based on clinical findings (e.g., LDL-cholesterol levels, history of coronary artery disease, physical exam), family history and genetic testing results (if known). Based on the score, individuals are categorized as definite, probable, possible or unlikely FH. Those with higher scores are more likely to have a causal mutation identified on genetic testing. The MEDPED criteria are based on age-adjusted cholesterol levels and factor into account family pedigree information (if known) with cutoffs designed to identify individuals who would have a causal mutation found on genetic testing.33
External validation in the Geisinger Healthcare System
The validation dataset contains a subset of the Geisinger data warehouse containing a total of 33,086 patients, with 3 million clinical notes, 32 million laboratory tests, 27 million medication orders. Geisinger investigators provided full NLP extraction of clinical terms using their internal text processing workflow for 5466 patients. The Geisinger data were mapped to the OHDSI CDM version 5.0 using vocabulary v5.0 11-MAR-16. The data contain 466 FH cases that have been diagnosed using the DLCN criteria,2 of which 236 FH cases were confirmed by genetic testing.
For external validation, we applied our Stanford classifier to unseen data from Geisinger. Note that directly classifying the external dataset with its native 466:5000 case to non-case ratio would lead to overly optimistic estimates of PPV. Therefore, we used a subset (n = 71) of the 466 Geisinger FH cases and controls (n = 4970) in a 1:70 ratio, to assess the ability of the classifier trained at Stanford to discriminate true cases from non-cases. We present the average results of the ten evaluation runs along with the standard deviation of the different metrics.
For all patient data, we have complied with all relevant ethical regulations and the study was approved by Stanford University′s institutional review board with waiver of informed patient consent. The model building was performed with de-identified data and only the members of the chart review team were provided with access to medical records. The study only made secondary use of already collected data. No patient direct interaction was performed as part of this study.
Further information on experimental design is available in the Nature Research Reporting Summary linked to this article.
The datasets analyzed during the current study are not publicly available: due to reasonable privacy and security concerns, the underlying EHR data are not easily redistributable to researchers other than those engaged in the Institutional Review Board-approved research collaborations in the FIND FH project.
All code and configuration parameters are available in: https://github.com/som-shahlab/findFH_aphrodite. We develop and tested this code in R version 3.2 and higher and with the OMOP CDM V5.3.
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The authors would like to thank the global community of FH patients. Kate Niehaus performed the preliminary experiments that led to this work. American Heart Association Summer 2014 Innovative Research Grant #15IRG22930034, The Stanford Data Science Initiative, Amgen “Full Potential Award” (paid to Stanford), J.K. is supported by the Stanford Diabetes Research Center (P30DK116074)
S.M. is an employee of Atomo LLC. M.M. has received personal fees from InVitae and Merck, and grant funding from Regeneron, outside the submitted work. K.M. is the founder of Atomo LLC. The remaining authors declare no competing interests. The FH Foundation (EIN 45-4597425) is a 501(c)3 public charity and research advocacy organization receiving funding from a diverse set of program sponsors including Amgen, Inc.
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Banda, J.M., Sarraju, A., Abbasi, F. et al. Finding missed cases of familial hypercholesterolemia in health systems using machine learning. npj Digit. Med. 2, 23 (2019). https://doi.org/10.1038/s41746-019-0101-5
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