Fig. 1: Oncoslice device for multiplexed microfluidic drug delivery to tissue. | npj Precision Oncology

Fig. 1: Oncoslice device for multiplexed microfluidic drug delivery to tissue.

From: Multiplexed drug testing of tumor slices using a microfluidic platform

Fig. 1

a Slices from glioma cell line-derived xenografts or patient tumors cultured on porous membranes were treated with drugs in six-well plates (one drug/well) or on the microfluidic device. A cell line drug screen guided drug choice. Responses were measured by fluorescence or tissue staining. b Oncoslice device assembly by bonding of laser-cut PMMA 40-well plate and microchannel layers. Image shows delivery of Cell Tracker Red, Cell Tracker Green, and Hoechst (blue) dyes to U87 xenograft slices. c Device cross-section shows wells, microchannel delivery to tissue slices, and a single syringe pump outlet. Scale bar: 1 cm.

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