Fig. 5 | npj Precision Oncology

Fig. 5

From: Precise definition of PTEN C-terminal epitopes and its implications in clinical oncology

Fig. 5

Schematic depiction of PTEN isoforms indicating the amino acid sequences of the linear epitopes recognized by the different anti-PTEN mAb. Numbers indicate the amino acid numbers. Numbering of PTEN-L is according to ref. 35 Amino acids are indicated by one-letter code. Ser and Thr residues in red are physiologically phosphorylated residues. The Lys residue in red can undergo acetylation. The arrows indicate the residues where PTEN is cleaved by caspase-3. The lines under the depicted amino acid sequence delimit the epitopes recognized by each mAb. Crosses indicate residues mutated in tumors or in patients whose substitution causes total or partial loss of mAb reactivity

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