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The weights of refinement and flexibility

IACUCs need to ensure the application of the 3Rs, while allowing researchers to conduct their work with reasonable flexibility. We invited experts from the University of Notre Dame (Eric Felde) and Northwestern University (Stefanie Bittner), along with USDA and OLAW representatives (Louis DiVincenti and Axel Wolff) to respond to a challenging situation at Great Eastern University.

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Correspondence to Lauren Danridge.

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The authors declare no competing interests.

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Disclaimer The views expressed in “A word from OLAW and USDA” represent the positions of OLAW/NIH and USDA, respectively, but the remainder of the contributions in this article do not represent official support or an endorsement by NIH, USDA, or any government agency.

Related links: PHS Policy on Humane Care and Use of Laboratory Animals – FAQs. Protocol Review, Question No. D.6.

PHS Policy on Humane Care and Use of Laboratory Animals – FAQs. Protocol Review, Question No. D.7.

PHS Policy on Humane Care and Use of Laboratory AnimalsFAQs. Protocol Review, Question No. D.11.

PHS Policy on Humane Care and Use of Laboratory Animals – FAQs. Animal Use and Management, Question No. F.19.

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Danridge, L., Greer, B., Felde, E. et al. The weights of refinement and flexibility. Lab Anim 53, 23–25 (2024).

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