Unlocking the secrets of the brain requires high precision tools to record neuronal activity. Neuroscientists have tools to capture neuronal activity with unprecedented speed, precision and fidelity. Thanks to a ground-breaking redesign of the linker peptide of GCaMP proteins, a domain seldomly considered for optimization, a new sensor bridges the gap between calcium imaging and electrophysiology.
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The authors declare no competing interests.
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Capaz, A.M., Renier, N. A closer look at jGCaMP8. Lab Anim 52, 147–148 (2023). https://doi.org/10.1038/s41684-023-01201-5