Know Your Model: The role of sex in phenotype penetrance and severity


There’s growing evidence that sex-based differences can influence phenotypes beyond those directly related to the reproductive system; to fully understand a gene’s function, researchers should consider both male and female subjects.

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MGD is supported by program project grant HG000330 from the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH).

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Correspondence to Susan M. Bello.

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Bello, S.M., Perry, M.N. & Smith, C.L. Know Your Model: The role of sex in phenotype penetrance and severity. Lab Anim 49, 239–240 (2020).

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