Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Aging-stroke interactions

Androvic, P. et al. Cell Rep 31, 107777 (2020)

The risk of ischemic stroke increases as people age, but the debilitating and often deadly occurrence tends to be studied in young mouse models. Likely as a result, preclinical results seldom translate to the clinic. To explore the influence of aging on stroke, researchers from the Czech Republic added aged animals to their experiments.

Looking genome-wide with RNA sequencing, the researchers compared transcription data from the brains of young (3 month old) and aged (18 month old) female C57Bl/6 mice three days following middle cerebral artery occlusion (MCAO), a model of ischemic stroke, and from age-matched controls. Nothing appeared particularly protective in the young animals, but the researchers recorded differential expression of genes involved in inflammation and interferon signaling in the aged mice, as well as downregulation of axon & synapse maintenance genes following MCAO.

Author information

Authors and Affiliations


Corresponding author

Correspondence to Ellen Neff.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Neff, E. Aging-stroke interactions. Lab Anim 49, 221 (2020).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing