Know Your Model: Why mouse inbred strain contribution matters

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Strain contributions arising from the strain of origin and backcrosses can modify phenotypic severity and/or penetrance of mutant alleles in mouse models.

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Fig. 1: Differences in Purkinje cell loss associated with Aarssti observed in mice on different genetic backgrounds.

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Acknowledgements

MGD is supported by program project grant HG000330 from the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH).

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Correspondence to Michelle N. Perry.

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Perry, M.N., Bello, S.M. & Smith, C.L. Know Your Model: Why mouse inbred strain contribution matters. Lab Anim 49, 133–134 (2020). https://doi.org/10.1038/s41684-020-0525-1

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