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Somatic base editing to model oncogenic drivers in breast cancer

Human cancer is a disease of cooperating genetic events that is complex to model in vivo. A new study combines somatic base editing with a mouse model of breast cancer, demonstrating the potential to rapidly investigate the function of disease-specific point mutations.

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Fig. 1: An expanding toolbox for modeling genetic aberrations in breast cancer.

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Correspondence to Kirsteen J. Campbell.

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Campbell, K.J., Blyth, K. Somatic base editing to model oncogenic drivers in breast cancer. Lab Anim 49, 115–116 (2020). https://doi.org/10.1038/s41684-020-0510-8

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