Rykiel, G. et al. eLife 9, e58138 (2020)
In a study published in eLife, investigators from Oregon Health & Science University describe a new imaging procedure to examine the heart of chicken embryos at an unprecedented level of detail. The method combines micro computed-tomography (micro-CT) imaging to acquire high-resolution images of the whole heart and scanning electron microscopy (SEM) to zoom into the tissue ultrastructure of the same heart.
The imaging procedure, which allowed the detection of subtle differences between a healthy chicken heart and a heart with a defect called tetralogy of Fallot, could be adapted for use in mouse and other small animal models and enhance our understanding of congenital heart disease.