Know Your Model: Microbiota & phenotypes

Host genetics, housing conditions, and antibiotic treatments impact microbiota diversity and composition, but microbes that inhabit the mouse gut and skin can also influence severity and penetrance of host mutant phenotypes.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Immunohistochemistry and images of visible tumors in mice with different microbiomes.

References

  1. 1.

    Robertson, S. J. et al. Cell Rep 27, 1910–1919.e2, https://doi.org/10.1016/j.celrep.2019.04.023 (2019).

    CAS  Article  PubMed  Google Scholar 

  2. 2.

    Weger, B. D. et al. Cell Metabol 29, 362–382.e8, https://doi.org/10.1016/j.cmet.2018.09.023 (2019).

    CAS  Article  Google Scholar 

  3. 3.

    Kennedy, E. A., King, K. Y. & Baldridge, M. T. Front Physiol 9, 1534, https://doi.org/10.3389/fphys.2018.01534 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  4. 4.

    Kong, H. H. et al. Genome Res 22, 850–859, https://doi.org/10.1101/gr.131029.111 (2012).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  5. 5.

    Kobayashi, T. et al. Immunity 42, 756–766, https://doi.org/10.1016/j.immuni.2015.03.014 (2015).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  6. 6.

    Kobayashi, T. et al. J Immunol 192, 1918–1927, https://doi.org/10.4049/jimmunol.1301819 (2014).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  7. 7.

    Sampson, T. R. et al. Cell 167, 1469–1480.e12, https://doi.org/10.1016/j.cell.2016.11.018 (2016).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  8. 8.

    Kadosh, E., et al. (2020). Nature https://doi.org/10.1038/s41586-020-2541-0

Download references

Acknowledgements

MGD is supported by program project grant HG000330 from the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH).

Author information

Affiliations

Authors

Corresponding author

Correspondence to Michelle N. Perry.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Perry, M.N., Bello, S.M. & Smith, C.L. Know Your Model: Microbiota & phenotypes. Lab Anim 49, 301–302 (2020). https://doi.org/10.1038/s41684-020-00660-4

Download citation

Search

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing