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Neuroscience

Modeling neurological disease using human stem cell-derived microglia-like cells transplanted into rodent brains

Microglia play important but incompletely understood roles in the pathogenesis of neurological disease. New chimeric models using transplanted human stem cell-derived microglia-like cells hold great promise to better model the unique function of human microglia in brain disease.

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Fig. 1: Human microglia/mouse brain chimeras for the study of AD-related transcriptional changes unique to human microglia in vivo.

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Correspondence to Fadi Jacob.

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Jacob, F., Bennett, M.L. Modeling neurological disease using human stem cell-derived microglia-like cells transplanted into rodent brains. Lab Anim 49, 49–51 (2020). https://doi.org/10.1038/s41684-019-0465-9

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