Neuroscience

Modeling neurological disease using human stem cell-derived microglia-like cells transplanted into rodent brains

Microglia play important but incompletely understood roles in the pathogenesis of neurological disease. New chimeric models using transplanted human stem cell-derived microglia-like cells hold great promise to better model the unique function of human microglia in brain disease.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Human microglia/mouse brain chimeras for the study of AD-related transcriptional changes unique to human microglia in vivo.

Created with BioRender

References

  1. 1.

    Hickman, S., Izzy, S., Sen, P., Morsett, L. & El Khoury, J. Nat. Neurosci. 21, 1359–1369 (2018).

    CAS  Article  Google Scholar 

  2. 2.

    Hammond, T. R., Robinton, D. & Stevens, B. Annu. Rev. Cell. Dev. Biol. 34, 523–544 (2018).

    CAS  Article  Google Scholar 

  3. 3.

    Mullane, K. & Williams, M. Curr. Protoc. Pharmacol. 84, e57 (2019).

    Article  Google Scholar 

  4. 4.

    Penney, J., Ralvenius, W. T. & Tsai, L. H. Mol. Psychiatry 1, 148–167 (2019).

    Google Scholar 

  5. 5.

    Abud, E. M. et al. Neuron 94, 278–293 (2017). e279.

    CAS  Article  Google Scholar 

  6. 6.

    Brownjohn, P. W. et al. Stem Cell Rep. 10, 1294–1307 (2018).

    CAS  Article  Google Scholar 

  7. 7.

    Garcia-Reitboeck, P. et al. Cell Rep. 24, 2300–2311 (2018).

    CAS  Article  Google Scholar 

  8. 8.

    Lin, Y. T. et al. Neuron 98, 1294 (2018).

    CAS  Article  Google Scholar 

  9. 9.

    Muffat, J. et al. Nat. Med. 22, 1358–1367 (2016).

    CAS  Article  Google Scholar 

  10. 10.

    Xu, M. et al. J. Alzheimers Dis. 67, 357–368 (2019).

    CAS  Article  Google Scholar 

  11. 11.

    Bennett, M. L. & Bennett, F. C. Nat. Neurosci. https://doi.org/10.1038/s41593-019-0545-6 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  12. 12.

    Hasselmann, J. et al. Neuron 103, 1016–1033 (2019). e1010.

    CAS  Article  Google Scholar 

  13. 13.

    Mancuso, R. et al. Nat. Neurosci. 22, 2111–2116 (2019).

    CAS  Article  Google Scholar 

  14. 14.

    Takata, K. et al. Immunity 47, 183–198 (2017). e186.

    CAS  Article  Google Scholar 

  15. 15.

    Hammond, T. R. & Stevens, B. Nat. Med. 22, 1206–1207 (2016).

    CAS  Article  Google Scholar 

  16. 16.

    Pandya, H. et al. Nat. Neurosci. 20, 753–759 (2017).

    CAS  Article  Google Scholar 

  17. 17.

    Oakley, H. et al. J. Neurosci. 26, 10129–10140 (2006).

    CAS  Article  Google Scholar 

  18. 18.

    Keren-Shaul, H. et al. Cell 169, 1276–1290 (2017). e1217.

    CAS  Article  Google Scholar 

  19. 19.

    Song, W. M. et al. J. Exp. Med. 215, 745–760 (2018).

    CAS  Article  Google Scholar 

  20. 20.

    Yuan, P. et al. Neuron 90, 724–739 (2016).

    CAS  Article  Google Scholar 

  21. 21.

    Liu, P. P., Xie, Y., Meng, X. Y. & Kang, J. S. Signal Transduct. Target Ther. 4, 29 (2019).

    Article  Google Scholar 

  22. 22.

    Rashid, T., Kobayashi, T. & Nakauchi, H. Cell Stem Cell 15, 406–409 (2014).

    CAS  Article  Google Scholar 

  23. 23.

    Wu, J. et al. Cell 168, 473–486 (2017). e415.

    CAS  Article  Google Scholar 

  24. 24.

    Qian, X., Song, H. & Ming, G. L. Development 146, https://doi.org/10.1242/dev.166074 (2019).

    CAS  Article  Google Scholar 

  25. 25.

    Park, J. et al. Nat. Neurosci. 21, 941–951 (2018).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Fadi Jacob.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Jacob, F., Bennett, M.L. Modeling neurological disease using human stem cell-derived microglia-like cells transplanted into rodent brains. Lab Anim 49, 49–51 (2020). https://doi.org/10.1038/s41684-019-0465-9

Download citation

Search

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing