Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Neuroscience

Modeling neurological disease using human stem cell-derived microglia-like cells transplanted into rodent brains

Lab Animal volume 49, pages 49–51 (2020)Cite this article

Subjects

Microglia play important but incompletely understood roles in the pathogenesis of neurological disease. New chimeric models using transplanted human stem cell-derived microglia-like cells hold great promise to better model the unique function of human microglia in brain disease.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Human microglia/mouse brain chimeras for the study of AD-related transcriptional changes unique to human microglia in vivo.

Created with BioRender

References

  1. Hickman, S., Izzy, S., Sen, P., Morsett, L. & El Khoury, J. Nat. Neurosci. 21, 1359–1369 (2018).

    Article  CAS  Google Scholar 

  2. Hammond, T. R., Robinton, D. & Stevens, B. Annu. Rev. Cell. Dev. Biol. 34, 523–544 (2018).

    Article  CAS  Google Scholar 

  3. Mullane, K. & Williams, M. Curr. Protoc. Pharmacol. 84, e57 (2019).

    Article  Google Scholar 

  4. Penney, J., Ralvenius, W. T. & Tsai, L. H. Mol. Psychiatry 1, 148–167 (2019).

    Google Scholar 

  5. Abud, E. M. et al. Neuron 94, 278–293 (2017). e279.

    Article  CAS  Google Scholar 

  6. Brownjohn, P. W. et al. Stem Cell Rep. 10, 1294–1307 (2018).

    Article  CAS  Google Scholar 

  7. Garcia-Reitboeck, P. et al. Cell Rep. 24, 2300–2311 (2018).

    Article  CAS  Google Scholar 

  8. Lin, Y. T. et al. Neuron 98, 1294 (2018).

    Article  CAS  Google Scholar 

  9. Muffat, J. et al. Nat. Med. 22, 1358–1367 (2016).

    Article  CAS  Google Scholar 

  10. Xu, M. et al. J. Alzheimers Dis. 67, 357–368 (2019).

    Article  CAS  Google Scholar 

  11. Bennett, M. L. & Bennett, F. C. Nat. Neurosci. https://doi.org/10.1038/s41593-019-0545-6 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  12. Hasselmann, J. et al. Neuron 103, 1016–1033 (2019). e1010.

    Article  CAS  Google Scholar 

  13. Mancuso, R. et al. Nat. Neurosci. 22, 2111–2116 (2019).

    Article  CAS  Google Scholar 

  14. Takata, K. et al. Immunity 47, 183–198 (2017). e186.

    Article  CAS  Google Scholar 

  15. Hammond, T. R. & Stevens, B. Nat. Med. 22, 1206–1207 (2016).

    Article  CAS  Google Scholar 

  16. Pandya, H. et al. Nat. Neurosci. 20, 753–759 (2017).

    Article  CAS  Google Scholar 

  17. Oakley, H. et al. J. Neurosci. 26, 10129–10140 (2006).

    Article  CAS  Google Scholar 

  18. Keren-Shaul, H. et al. Cell 169, 1276–1290 (2017). e1217.

    Article  CAS  Google Scholar 

  19. Song, W. M. et al. J. Exp. Med. 215, 745–760 (2018).

    Article  CAS  Google Scholar 

  20. Yuan, P. et al. Neuron 90, 724–739 (2016).

    Article  CAS  Google Scholar 

  21. Liu, P. P., Xie, Y., Meng, X. Y. & Kang, J. S. Signal Transduct. Target Ther. 4, 29 (2019).

    Article  Google Scholar 

  22. Rashid, T., Kobayashi, T. & Nakauchi, H. Cell Stem Cell 15, 406–409 (2014).

    Article  CAS  Google Scholar 

  23. Wu, J. et al. Cell 168, 473–486 (2017). e415.

    Article  CAS  Google Scholar 

  24. Qian, X., Song, H. & Ming, G. L. Development 146, https://doi.org/10.1242/dev.166074 (2019).

    Article  CAS  Google Scholar 

  25. Park, J. et al. Nat. Neurosci. 21, 941–951 (2018).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA

    Fadi Jacob

  2. Medical Scientist Training Program, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA

    Fadi Jacob

  3. Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Fadi Jacob

  4. Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA, 19104, USA

    Mariko L. Bennett

Authors
  1. Fadi Jacob
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mariko L. Bennett
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Fadi Jacob.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Jacob, F., Bennett, M.L. Modeling neurological disease using human stem cell-derived microglia-like cells transplanted into rodent brains. Lab Anim 49, 49–51 (2020). https://doi.org/10.1038/s41684-019-0465-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41684-019-0465-9

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing