Many studies have reported on the identification of ‘essential genes’ in mice, but the context of the experimental model, including genetic background and specific molecular details of the allele, may impact the influence of alleles on viability.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Essential genes: a cross-species perspective
Mammalian Genome Open Access 10 March 2023
Access options
Subscribe to this journal
We are sorry, but there is no personal subscription option available for your country.
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Dickinson, M. E. et al. Nature 537, 508–514 (2016).
Miller, A. R., Hawkins, N. A., McCollom, C. E. & Kearney, J. A. Genes, Brain Behav. 13, 163–172 (2014).
Leder, A., McMenamin, J., Fontaine, K., Bishop, A. & Leder, P. Hum. Mol. Genet. 14, 615–625 (2005).
Valdez, B. C., Henning, D., So, R. B., Dixon, J. & Dixon, M. J. Proc. Natl. Acad. Sci. 101, 10709–10714 (2004).
Dixon, J., Brakebusch, C., Fässler, R. & Dixon, M. J. Hum. Mol. Genet. 9, 1473–1480 (2000).
Dixon, J. & Dixon, M. J. Dev. Dyn. 229, 907–914 (2004).
Dixon, J. et al. Proc. Natl. Acad. Sci. 103, 13403–13408 (2006).
Braun, T. & Arnold, H. H. EMBO J. 14, 1176–86 (1995).
Patapoutian, A. et al. Development 121, 3347–58 (1995).
Zhang, W., Behringer, R. R. & Olson, E. N. Genes Dev. 9, 1388–1399 (1995).
Floss, T., Arnold, H. H. & Braun, T. Dev. Biol. 174, 140–147 (1996).
Yoon, J. K., Olson, E. N., Arnold, H.-H. & Wold, B. J. Dev. Biol. 188, 349–362 (1997).
Simon, M. M. et al. Genome Biol. 14, R82 (2013).
Kendall, A. & Schacht, J. Hear. Res. 318, 18–22 (2014).
Hull, R. L. et al. J. Endocrinol. 233, 53–64 (2017).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Acknowledgements
MGD is supported by program project grant HG000330 from the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH).
Rights and permissions
About this article
Cite this article
Bello, S.M., Berry, M.L. & Smith, C.L. Know Your Model: How essential is that essential gene?. Lab Anim 49, 9–10 (2020). https://doi.org/10.1038/s41684-019-0444-1
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41684-019-0444-1
This article is cited by
-
Essential genes: a cross-species perspective
Mammalian Genome (2023)