A wild microbiome improves mouse modeling of the human immune response

With the genetics of a laboratory strain but a more diverse microbiome, ‘wildling’ mice could be a novel complement to commonly used specific pathogen-free animals in preclinical studies.

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Fig. 1: Wildling mice, the offspring of pseudo-pregnant wild mice implanted with C57BL/6 mouse embryos, combine the shared genetics of traditional, specific pathogen free C57BL/6 laboratory mice (SPF) with the microbiome diversity and resilience found in wild mice.


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Correspondence to Sara E. Hamilton or Thomas S. Griffith.

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Hamilton, S.E., Griffith, T.S. A wild microbiome improves mouse modeling of the human immune response. Lab Anim 48, 337–338 (2019). https://doi.org/10.1038/s41684-019-0421-8

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