Experimental models of disease

A zebrafish genetic model enables an invaluable discovery: a lifesaving treatment for a lymphatic anomaly

In medical research, treatments are often thought of as moving “from bench to bedside.” A new study identifies a specific treatment in zebrafish and brings it to a patient, highlighting the role of these animal models in personalized medicine.

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Fig. 1: The lymphoedema in patients and disrupted lymphatic phenotypes in cell culture and a larval zebrafish model, caused by the gain-of-function mutation in ARAF, can be treated with a MEK inhibitor.

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Correspondence to Katarzyna Koltowska.

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Koltowska, K. A zebrafish genetic model enables an invaluable discovery: a lifesaving treatment for a lymphatic anomaly. Lab Anim 48, 305–306 (2019). https://doi.org/10.1038/s41684-019-0401-z

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