In medical research, treatments are often thought of as moving “from bench to bedside.” A new study identifies a specific treatment in zebrafish and brings it to a patient, highlighting the role of these animal models in personalized medicine.
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References
Trevaskis, N. L., Kaminskas, L. M. & Porter, C. J. H. Nat Rev Drug Discov 14, 781–803 (2015).
Li, D. et al. Nat Med 25, 1116–1122, https://doi.org/10.1038/s41591-019-0479-2 (2019).
Brouillard, P., Boon, L. & Vikkula, M. J. Clin. Invest. 124, 898–904 (2014).
Deng, Y., Atri, D., Eichmann, A. & Simons, M. Endothelial ERK signaling controls lymphatic fate specification. J. Clin. Invest. 123, 1202–1215 (2013).
Ichise, T., Yoshida, N. & Ichise, H. Development 137, 1003–1013 (2010).
Le Guen, L. et al. Development 141, 1239–1249 (2014).
Schulz, M. M. et al. Proc Natl Acad Sci USA 109, E2665–2674 (2012).
Yaniv, K. et al. Nat Med 12, 711–716 (2006).
Küchler, A. M. et al. Curr Biol 16, 1244–1248 (2006).
Koltowska, K., Betterman, K. L., Harvey, N. L. & Hogan, B. M. Development 140, 1857–1870 (2013).
Hogan, B. M. et al. Development 136, 4001–4009 (2009).
Koltowska, K. et al. Cell Rep 13, 1828–1841 (2015).
Shin, M. et al. Development 143, 3785–3795 (2016).
Coxam, B. et al. Cell Rep 7, 623–633 (2014).
Koltowska, K. et al. Genes Dev 29, 1618–1630 (2015).
Karpanen, T. et al. Circ Res 120, 1263–1275 (2017).
Hogan, B. M. et al. Nat Genet 41, 396–398 (2009).
Alders, M. et al. Nat Genet 41, 1272–1274 (2009).
Nicenboim, J. et al. Nature 522, 56–61 (2015).
Eng, T. C. et al. EMBO Rep 17, e47079, https://doi.org/10.15252/embr.201847079 (2019).
Potente, M. & Mäkinen, T. Nat Rev Mol Cell Biol 18, 477–494 (2017).
Astin, J. W. et al. Mol Cancer Ther 13, 2450–2462 (2014).
Astin, J. W. & Crosier, P. S. Adv. Exp. Med. Biol. 916, 199–218 (2016).
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Koltowska, K. A zebrafish genetic model enables an invaluable discovery: a lifesaving treatment for a lymphatic anomaly. Lab Anim 48, 305–306 (2019). https://doi.org/10.1038/s41684-019-0401-z
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DOI: https://doi.org/10.1038/s41684-019-0401-z