When all is not lost: considering genetic compensation in laboratory animals

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A recent article by El-Brolosy and colleagues introduced an unexpected twist for our understanding of knock-out mutations by revealing compensatory mechanisms that recruit the expression of other genes to mitigate the consequences of the mutation. We discuss the main findings of the paper and their impact for our interpretations of the effects of mutations in laboratory animals and humans.

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Fig. 1: Gene knock-out and gene knock-down.
Fig. 2: Proposed mechanisms of transcriptional adaptation.

References

  1. 1.

    MacArthur, D. G. et al. Science. 335, 823–828 (2012).

    CAS  Article  Google Scholar 

  2. 2.

    Barbaric, I., Miller, G. & Dear, T. N. Briefings Funct. Genomics Proteomics 6, 91–103 (2007).

    CAS  Article  Google Scholar 

  3. 3.

    Housden, B. E. et al. Nat. Rev. Genet. 18, 24–40 (2017).

    CAS  Article  Google Scholar 

  4. 4.

    Kok, F. O. et al. Dev. Cell 32, 97–108 (2015).

    CAS  Article  Google Scholar 

  5. 5.

    Rossi, A. et al. Nature 524, 230–233 (2015).

    CAS  Article  Google Scholar 

  6. 6.

    De Souza, A. T. et al. Nucleic Acids Res. 34, 4486–4494 (2006).

    Article  Google Scholar 

  7. 7.

    O’Leary, M. N. et al. PLoS Genet. 9, (2013).

  8. 8.

    El-Brolosy, M. A. & Stainier, D. Y. R. PLoS Genet. 13, 1–17 (2017).

    Article  Google Scholar 

  9. 9.

    El-Brolosy, M. A. et al. Nature 568, 193–197 (2019).

    CAS  Article  Google Scholar 

  10. 10.

    Kurosaki, T., Popp, M. W. & Maquat, L. E. Nat. Rev. Mol. Cell Biol. 20, 406–420 (2019).

    CAS  Article  Google Scholar 

  11. 11.

    Ma, Z. et al. Nature 568, 259–263 (2019).

    CAS  Article  Google Scholar 

  12. 12.

    Morgens, D. W., Deans, R. M., Li, A. & Bassik, M. C. Nat. Biotechnol. 34, 634–636 (2016).

    CAS  Article  Google Scholar 

  13. 13.

    Majidinia, M., Sadeghpour, A. & Yousefi, B. J. Cell. Physiol. 233, 2937–2948 (2018).

    CAS  Article  Google Scholar 

  14. 14.

    Breschi, A., Gingeras, T. R. & Guigó, R. Nat. Rev. Genet. 18, 425–440 (2017).

    CAS  Article  Google Scholar 

  15. 15.

    Pertea, M. et al. Genome Biol. 19, 208 (2018).

    CAS  Article  Google Scholar 

  16. 16.

    Fischer, S. E. J. Curr. Protoc. Mol. Biol. 2015, (2015).

Download references

Acknowledgements

The authors thank Dr Louise Tinsley for expert assistance with the preparation of the manuscript.

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Correspondence to Lydia Teboul.

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Bunton-Stasyshyn, R.K.A., Wells, S. & Teboul, L. When all is not lost: considering genetic compensation in laboratory animals. Lab Anim 48, 282–284 (2019). https://doi.org/10.1038/s41684-019-0397-4

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