When all is not lost: considering genetic compensation in laboratory animals


A recent article by El-Brolosy and colleagues introduced an unexpected twist for our understanding of knock-out mutations by revealing compensatory mechanisms that recruit the expression of other genes to mitigate the consequences of the mutation. We discuss the main findings of the paper and their impact for our interpretations of the effects of mutations in laboratory animals and humans.

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Fig. 1: Gene knock-out and gene knock-down.
Fig. 2: Proposed mechanisms of transcriptional adaptation.


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The authors thank Dr Louise Tinsley for expert assistance with the preparation of the manuscript.

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Correspondence to Lydia Teboul.

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Bunton-Stasyshyn, R.K.A., Wells, S. & Teboul, L. When all is not lost: considering genetic compensation in laboratory animals. Lab Anim 48, 282–284 (2019). https://doi.org/10.1038/s41684-019-0397-4

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