Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Animal disease models

Modeling genetic diversity in Alzheimer’s disease

Lab Animal volume 48, pages 87–88 (2019)Cite this article

Subjects

There are a number of genetic factors that contribute to Alzheimer’s disease in people. A new mouse model attempts to better capture that variability.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Schematics of the AD model cross with BXD Strains (A) and phenotyping process (B).

References

  1. Neuner, S.M., Heuer, S.E., Huentelman, M.J., O’Connell, K.M.S. & Kaczorowski, C.C. Neuron doi: 10.1016/j.neuron.2018.11.040 (2018).

  2. Peirce, J. L., Lu, L., Gu, J., Silver, L. M. & Williams, R. W. BMC Genet. 5, 7 (2004).

    Article  Google Scholar 

  3. Gatz, M. et al. J. Gerontol. A Biol. Sci. Med. Sci. 52, M117–125 (1997).

    Article  CAS  Google Scholar 

  4. Ryman, D. C. et al. Neurology 83, 253–260 (2014).

    Article  CAS  Google Scholar 

  5. Hargis, K. E. & Blalock, E. M. Behav. Brain Res. 322, 311–328 (2017).

    Article  CAS  Google Scholar 

  6. International Genomics of Alzheimer’s Disease, C. Alzheimers Dement 11, 658–671 (2015).

    Article  Google Scholar 

  7. Zhang, B. et al. Cell 153, 707–720 (2013).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dept. of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, USA

    Katherine R. Sadleir & Robert Vassar

Authors
  1. Katherine R. Sadleir
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Robert Vassar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Katherine R. Sadleir.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sadleir, K.R., Vassar, R. Modeling genetic diversity in Alzheimer’s disease. Lab Anim 48, 87–88 (2019). https://doi.org/10.1038/s41684-019-0248-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41684-019-0248-3

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing