Animal disease models

Modeling genetic diversity in Alzheimer’s disease

There are a number of genetic factors that contribute to Alzheimer’s disease in people. A new mouse model attempts to better capture that variability.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Schematics of the AD model cross with BXD Strains (A) and phenotyping process (B).


  1. 1.

    Neuner, S.M., Heuer, S.E., Huentelman, M.J., O’Connell, K.M.S. & Kaczorowski, C.C. Neuron doi: 10.1016/j.neuron.2018.11.040 (2018).

  2. 2.

    Peirce, J. L., Lu, L., Gu, J., Silver, L. M. & Williams, R. W. BMC Genet. 5, 7 (2004).

    Article  Google Scholar 

  3. 3.

    Gatz, M. et al. J. Gerontol. A Biol. Sci. Med. Sci. 52, M117–125 (1997).

    CAS  Article  Google Scholar 

  4. 4.

    Ryman, D. C. et al. Neurology 83, 253–260 (2014).

    CAS  Article  Google Scholar 

  5. 5.

    Hargis, K. E. & Blalock, E. M. Behav. Brain Res. 322, 311–328 (2017).

    CAS  Article  Google Scholar 

  6. 6.

    International Genomics of Alzheimer’s Disease, C. Alzheimers Dement 11, 658–671 (2015).

    Article  Google Scholar 

  7. 7.

    Zhang, B. et al. Cell 153, 707–720 (2013).

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Katherine R. Sadleir.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Sadleir, K.R., Vassar, R. Modeling genetic diversity in Alzheimer’s disease. Lab Anim 48, 87–88 (2019).

Download citation


Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing