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Redirecting the request to the IACUC

Lab Animal volume 47, pages 140–141 (2018)Cite this article

Due to the shortage of pharmaceutical-grade buprenorphine, the IACUC and Attending Veterinarian are faced with the challenge of determining which situation is more appropriate: allow Dr. Rosenfeld to use non-pharmaceutical-grade buprenorphine, allow her to use expired pharmaceutical-grade buprenorphine, or allow neither, postponing the research until pharmaceutical-grade buprenorphine becomes available.

Guidance provided by OLAW indicates that use of expired analgesics is inconsistent with acceptable veterinary practices and adequate veterinary care. OLAW does not provide for the use of analgesics beyond their expiration date under any circumstances. Therefore, even though the expired buprenorphine would be used as a negative control for an experimental procedure, its use would be contradictory to OLAW recommendations and should not be approved1.

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References

  1. Office of Laboratory Animal Welfare, National Institutes of Health. Frequently asked questions: PHS Policy on humane care and use of laboratory animals. National institutes of Health Office of Extramural Research. https://grants.nih.gov/grants/olaw/faqs.htm#663 (2017).

  2. Institute for Laboratory Animal Research. Guide for the Care and Use of Laboratory Animals 8th edn (National Academies Press, Washington, DC, 2011).

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  3. AAALAC International. Frequently asked questions: Non-pharmaceutical-grade compounds. https://www.aaalac.org/accreditation/faq_landing.cfm#B9 (2017).

  4. National Institutes of Health. Guidance on Significant Changes to Animal Activities. Notice NOT-OD-14-126. (National Institutes of Health, Washington, DC, 26 August 2014).

  5. Office of Laboratory Animal Welfare, National Institutes of Health. Position statement 3) non-pharmaceutical-grade substances. National institutes of Health Office of Extramural Research. https://grants.nih.gov/grants/olaw/positionstatement_guide.htm#position (2017).

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Authors and Affiliations

  1. University of Georgia, Athens, Georgia, USA

    Lois A. Zitzow & Leanne C. Alworth

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  1. Lois A. Zitzow
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  2. Leanne C. Alworth
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Correspondence to Lois A. Zitzow.

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Zitzow, L.A., Alworth, L.C. Redirecting the request to the IACUC. Lab Anim 47, 140–141 (2018). https://doi.org/10.1038/s41684-018-0071-2

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