Utilizing geospatial artificial intelligence to map cancer disparities across health regions

We have developed an innovative tool, the Intelligent Catchment Analysis Tool (iCAT), designed to identify and address healthcare disparities across specific regions. Powered by Artificial Intelligence and Machine Learning, our tool employs a robust Geographic Information System (GIS) to map healthcare outcomes and disease disparities. iCAT allows users to query publicly available data sources, health system data, and treatment data, offering insights into gaps and disparities in diagnosis and treatment paradigms. This project aims to promote best practices to bridge the gap in healthcare access, resources, education, and economic opportunities. The project aims to engage local and regional stakeholders in data collection and evaluation, including patients, providers, and organizations. Their active involvement helps refine the platform and guides targeted interventions for more effective outcomes. In this paper, we present two sample illustrations demonstrating how iCAT identifies healthcare disparities and analyzes the impact of social and environmental variables on outcomes. Over time, this platform can help communities make decisions to optimize resource allocation.

real-time analysis for swift identification of emerging health trends and timely interventions.This paradigm shift promises to revolutionize healthcare decision-making and outcomes, showcasing the power of AI/ML to solve this challenge.
GIS technology utilizes spatial data and maps to analyze and visualize patterns and trends within a geographic context 6 .High-level analysis can help map the environmental elements associated with disease disparities and offer evidence-based support for logical diagnosis and treatment plans 7 .Studies have demonstrated that GIS can integrate various data types, including demographic, environmental, and healthcare information, to understand the complex factors contributing to disease disparities 8 .Over time, as users query increasingly complex datasets, the data may contain nonlinear dynamics that require advanced algorithmic approaches to organize and efficiently optimize data analysis 9 .It may also be of wide interest for users to employ intelligent neuro-supervised networks (INSNs) to study variations across different regional locations 10 .The accuracy and analytical speed of analysis of large geographic datasets can benefit from enhanced fractional stochastic gradient descent (EFSGD) approaches that employ matrix factorization to improve prediction accuracy 11 .
Integrating AI with GIS enables us to pinpoint areas with high disease prevalence, study environmental and social factors contributing to cancer disparities, and assist in developing evidence-based prevention and treatment strategies.By incorporating the data from localized catchment areas with advanced treatment modalities and comparing it to areas with poor outcomes, GIS can help researchers and health systems understand the root causes of health disparities and develop interventions to reduce them.

New application design
We designed the iCAT application with intelligence to allow users to visualize geospatial health data on a map and perform ML/AI analysis with valid embedded models.By leveraging demographic, environmental, and healthcare access data, users can perform sophisticated univariate and multivariate AI models to identify patterns and trends in disease incidence rates.This application can identify barriers to accessing screening and treatment, analyze survey and interview data, and inform policy and interventions to address healthcare disparities.

Mapping health disparities by disease type using specialized cancers as a model
Cancer disparities refer to the unequal distribution and burden of cancer among different population groups, often based on race, ethnicity, socioeconomic status, and geographic location.To build a comprehensive health disparity analysis tool that includes all cancer types, we focused initially on gynecologic cancers, where known outcome disparities have been reported in the literature 12 .Gynecologic cancers, including cervical, ovarian, uterine, and vulvar cancer, have been identified as a subgroup of interest for GIS studies.In 2018, there were an estimated 570,000 new cases of cervical cancer and 311,000 deaths worldwide, with nearly 90% of patients being from low and middle-income countries 13,14 .The advent of human papillomavirus (HPV) vaccines for high-risk subtypes of cervical cancer and early interventions in at-risk populations provide effective treatment options when identified early 15 .
By analyzing data from the GIS platform, researchers, community advocates, health systems, and legislative bodies can address the root causes of health disparities and improve disease outcomes.It is important to note that statistical knowledge is necessary to evaluate the significance of relationships and correlations between factors.While these tests are robust, guidance from a statistician may be helpful to verify model assumptions, including confounding factors or data transformations that may impact correlation size.

Defining a geographic catchment area
We defined our initial boundary geography as the University of Chicago Medicine Comprehensive Cancer Center (UCCCC) catchment area, a five-county area around the University of Chicago Medical Center on the south side of Chicago.This area includes 83% of UCCCC cancer patients and 62% of clinical trial patients.The included counties are Cook County, IL, the broader Chicago metropolitan area; DuPage County, IL; Will County, IL; Lake County, IL; and Lake County, IN.These counties have the highest population density in IL and IN and an estimated combined population of approximately 8 million.The population of the total catchment area has a racial and ethnic breakdown of residents as 49% non-Hispanic white, 22% Hispanic, 19% Black, and 8% Asian.This catchment area has a high rate of poverty and social deprivation, known barriers to cancer screening, timely and quality cancer care, and limited resources for cancer survivorship.

Data collection and availability
Deidentified health, demographic, socio-economic, and environmental data were obtained from publicly available relevant sources, such as the Chicago Health Atlas 16 and the Chicago Data Portal 17 .Spatial cancer mortality data related to the catchment area were collected and matched with demographic, socio-economic, health, and spatial data and are available for use in the iCAT application.

Software
iCAT is built using R statistical software package (v 4.2.1)(2022-6-23) available at: https:// cran.r-project.org/ bin/ windo ws/ Rtools/ rtool s42/ rtools.html 18 and the R shiny package (v 1.7.4) available at: https:// www.rdocu menta tion.org/ packa ges/ shiny/ versi ons/1.7.4 19 .The leaflet r package (v 2.1.2) 20 is an R implementation of the leaflet JavaScript library used for plotting GIS data on a map.The caret package (v 6.0-94) and its dependencies in R perform the bulk of the AI/ML analysis and is available at https:// www.rdocu menta tion.org/ packa ges/ caret/ versi ons/6.0-94.The platform uses RShiny to build a user-friendly interface optimized for simplicity.A sidebar with specific tabs for each task allows the user to navigate around and efficiently perform the required analysis.Moreover, a guide tab is included to acquaint the user with the different functionalities of the tool, and an in-app example dataset is provided to help the user study cancer outcomes within the catchment area.The application incorporates tabs that report the results of various analyses, including mapping visual distributions, correlation, and multivariate.This enables users to study the results of multiple analysis methods simultaneously and draw informative conclusions.

GIS health data visualization
Visualization of the data on a map of the boundary area is performed using the leaflet package.This package allows the visualization of different layers on the same map to study multiple variables simultaneously.It works efficiently across all desktop and mobile operating systems, with an interactive experience and the capability to adjust the map's scale to focus on a catchment area of interest.The plotting data render numeric variables using a gradient coloring scale, implying a continuous spectrum across the values.In contrast, categorical variables are presented with each category as entirely distinct.

Univariate analysis and statistical tests
iCAT uses univariate analysis to aid in understanding the effect of a single variable on a health outcome (i.e., cancer mortality).It identifies the root causes of health disparities and improves cancer outcomes.Examples of this are vast and can range from studying the relationship between smoking or socio-economic status on lung cancer mortality to the relation between routine check-ups and cervical cancer mortality.iCAT provides statistical measures and tests that can be readily used to test the significance of univariate relations.For example, the size of the Pearson correlation between smoking and lung cancer can be calculated and returned as a measure of the relation between the two variables.A t-test can be performed to study the significance of this correlation measure.Univariate analysis can be performed by selecting the primary and secondary variables and choosing Pearson's or Spearman's correlation as the analysis method to measure the correlation between the two variables.Appropriate statistical tests can be performed to assess the significance of the correlation.The results of the correlation analysis are presented using the raw data after using iCAT 's statistical AI to perform data transformations and remove outliers in the variables.iCAT 's statistical AI provides the user with an overall evaluation of the model, including checks for confounding factors, which helps thoroughly assess results without advanced statistical experience.

Multivariate analysis using machine learning
The application uses multivariate analysis to assess the effect of multiple variables on the outcome variable simultaneously to provide a better understanding of the contribution of various social and environmental variables to health disparity outcomes.ML systems can accept many dimensions and explain essential features instead of analyzing them manually one at a time.iCAT provides access to various linear and non-linear machine learning algorithms (such as linear regression, logistic regression, GBMs, Neural Networks, and Lasso Regression) based on the problem and reports the significant features.It ranks them based on their impact on the response of interest.Multivariate analysis can be performed by selecting the primary and secondary variables in the analysis tab and selecting the required analysis method.
Multiple machine learning algorithms in iCAT allow the user to select the analysis that fits the data and health question of interest.Linear regression models are used to study the linear relationship of various social and environmental variables on continuous health disparity outcomes (i.e.cancer mortality rate) 21 , while logistic regression provides the user with the ability to study important factors affecting the presence or absence of health disparity outcomes 22 .GBMs and Neural Networks are powerful AI models that can study non-linear relationships between various social and environmental variables and health disparity outcomes 23,24 .Lasso regression models are also available to allow the user to study the effect of many correlated variables on the health outcome without worrying about confounding factors 25 .The statistical AI in the app's back end allows the user to provide the data and lets the app select the most appropriate multivariate method to analyze the data.

iCAT statistical AI
Intelligent statistical and data analysis relies on AI to test assumptions and troubleshoot any issues related to the data evaluation.Techniques used in this process include but are not limited to data cleaning and preprocessing (i.e., removing outliers), data engineering and transformation (i.e., transforming to normal distribution), knowledge filtering (i.e., eliminating confounding factors), recommendation systems (i.e., recommending important health disparity factors in cancer outcomes).These methods are utilized in the statistical AI present in iCAT to give the user an easy way to gain confidence in the statistical and machine learning models and analysis results presented.
Several unique features built into iCAT provide intelligent data analysis, including data transformation, data processing, confounding checks, and disparity recommendations, and are described below.

Data transformation
The data selected for analysis is assessed to ensure correct assumptions of the analysis method and proper data transformations are applied when necessary.This is enabled using the tool's underlying statistical AI and the bestNormalize R package.Appropriate regular transformations are initially applied to the input data from wellknown available transformations such as Lambert W x F transform, Box-Cox transform, Yeo-Johnson transforms, and Ordered Quantile.The best transformation is then selected by calculating the Pearson P statistic divided by www.nature.com/scientificreports/its degrees of freedom for each transformation.The transformation that allows the data to best-fit normality is selected and applied to the data (Fig. 1).

Data cleaning and outlier removal
The normal transformed data are cleaned by removing potential outliers.The outliers are selected using the interquartile method.This method first calculates the interquartile range (IQR) as the distance between the 1 st and 3 rd quartiles (Q1-Q3).It then assumes any value outside the range [Q1-1.5 × IQR, Q3 + 1.5 × IQR] is an outlier.Outliers are removed from the dataset to avoid potential interference with the analysis results.

Confounding factors
The presence of potential confounding factors that can affect the result of the statistical models is assessed, and the results before and after accounting for confounding factors are presented to the user.This is possible due to the app's focus on the set catchment area and the comprehensive demographic and metadata available to assess confounding.
The presence of confounding factors is assessed using linear models in the following way: Initially, a single variable linear model is fit using the primary variable of interest (i.e., Cancer mortality) as the response variable and the second variable in the univariate analysis as the covariate in the model.iCAT then includes internal metadata columns as potential confounders to the model.Subsequently, the percent change in the coefficient of the second variable in the first and second linear models is calculated.The generally accepted practice finds that a percentage change exceeding 10% can point to the potential presence of confounders or other variables that explain the variance in the primary variable of interest 26 .iCAT reports the result of this analysis in addition to the correlation matrix between the variables of interest and the potential confounders for the user to view.It also provides the potential confounders and calculates the correlation after accounting for confounding variables.

Recommendations for health disparity factors in cancer outcomes
iCAT can provide recommendations on important demographic, socio-economic, and environmental factors on a given cancer outcome based on a statistical reference to similar factors in the selected area of interest.The desired primary outcome can be programmatically estimated using the appropriate ML multivariate analysis method to identify relevant factors in determining the cancer outcome.The app can 'learn' using the data in the area of interest.This can help scientists understand hidden health disparity factors and recommend interventions promptly that can lead to better prevention of cancer-related mortality.

Results and discussion
The iCAT geo-analyzer is a publicly available online interactive tool at: https:// cance rcatc hment areas.godad dysit es.com/ The iCAT geo-analyzer enables users to quantify disease burden in cancer over multiple years.Users can filter the results by year, age group, and a minimum number of diagnoses.Users can also study the disparity in cancer burden in the catchment area using different statistical and ML analysis methods.This paper presents two use examples of the application to investigate cancer burden in the University of Chicago Comprehensive Cancer Center service catchment area.

Example 1: Evaluating disparities in cervical cancer mortality rate in Cook County, IL
Using the iCAT application to study this question, the distribution of cervical cancer mortality rates in different communities in Cook County, IL, can be seen in Fig. 2. The communities are colored by the value of the selected variable, with darker purple showing higher values of the selected variable.Using correlation analysis in iCAT , we can test the correlation between cervical cancer mortality and poverty rates.This is done by choosing the cervical cancer mortality rate as the primary and the poverty rate as the secondary variable and assigning the Pearson Correlation method from the drop-down menu in the Analysis tab.
Table 1 demonstrates two different correlation analysis results.First, Pearson's correlation coefficient was calculated using the raw data.Second, Pearson's correlation coefficient was calculated after using the underlying statistical AI to clean and transform data to the appropriate format expected by the analysis method.After applying statistical intelligence, a highly significant correlation coefficient of 0.48 is reported.In the next step, iCAT checks for potential confounders using in-app demographic and socio-economic data from the catchment area (Table 2).
After removing the effect of potential confounders from the primary variable, we identify no significant correlation between cervical cancer mortality and poverty rate.Close observation of the correlation matrix shows that the community's female demographic and neighborhood safety rate are potential confounders of the analysis, so we need to account for these dependencies when studying cervical cancer.iCAT allows multivariate analysis to study the effect of multiple variables on the cervical cancer mortality rate simultaneously.This feature can study the effect of poverty rate on cervical cancer mortality while controlling for confounders.The multivariate analysis selects the cervical cancer mortality rate as the primary variable and the poverty rate, female demographics, and neighborhood safety rate as the secondary variables.For this analysis, using a simple linear regression model, the results of the multivariate analysis show that when controlling for the female demographic, the neighborhood safety rate is a significant contributor to explaining the cervical cancer mortality rate.In contrast, the poverty rate shows no significant contribution (Table 3, Fig. 3).This exciting result points out the neighborhood safety rate as a contributor to the cervical cancer mortality rate rather than the poverty rate.The distribution of cancer mortality rates in different communities in Cook County, IL, can be visualized in Fig. 4. Using multivariate analysis in iCAT , we can test the relation between cancer mortality and multiple demographics, socio-economic variables, and other variables.This is done by choosing the cancer mortality rate as the primary factor, and demographic, socio-economic, and other factors as the secondary variables and assigning the linear regression method from the drop-down menu in the Analysis tab.The importance of the secondary variables in explaining the overall cancer mortality rate in the designated area can be seen in Fig. 5 and Table 4.In this case, three factors significantly contribute to the overall cancer mortality rate: poverty and teen birth rates show a positive relationship, and the uninsured rate negatively correlates with overall cancer mortality.
The example illustrations show the importance of iCAT in studying disease outcomes in health disparity populations.In a similar situation, many available GIS applications may have reported the result of a positive correlation between cervical cancer mortality and poverty rates.By accounting for potential confounders, the statistical AI in iCAT allows us to make more reliable inferences and avoid costly mistakes due to incorrect analysis results.Using the innovative GIS in this tool, we expect to identify patterns and trends in health disparity results within the catchment area.We also hope to identify potential social and environmental factors contributing to these disparities.
This GIS project can utilize data on demographic characteristics, lifestyle behaviors, and environmental exposures to identify patterns and trends in disease incidence and outcomes.An AI-GIS analysis may reduce the disease burden by revealing higher cervical cancer rates in specific neighborhoods by discovery of environmental exposures or lifestyle behaviors.This can help community leaders implement interventions such as increasing access to screening and education on risk reduction strategies.

Limitations
Presently, we have populated only a narrow data set into the model, which restricts the dynamic capabilities of the application along the machine learning overlays.A comprehensive dataset will further improve the performance of the tool's underlying statistical AI, which, in turn, improves the accuracy of the data analysis results.Over time, incidence data, demographic information, environmental exposure data, healthcare access, and quality of care will be expanded and can provide a higher-powered dataset to harvest.Another limitation is that we still need to integrate logic to verify the data sources are reliable and up-to-date.

Conclusion
AI-GIS platforms offer a powerful tool to pinpoint drivers of health disparities.We demonstrated two examples of the impact of social and environmental variables on cervical cancer mortality and overall cancer mortality rates.This type of analysis can serve as a template for leveraging big data to provide useful conclusions about regional disparities.Ultimately, enhanced AI algorithmic strategies and output analysis can drive tactical resource allocation to reduce disparities over time.We demonstrated how the AI-GIS platform can answer user queries about specific health disparity information and uncover the finding that neighborhood safety rate contributes to the cervical cancer mortality rate rather than the poverty rate.

Future directions
In addition to analyzing data on one disease within one region, larger-scale data analysis can encompass many diseases and multiple communities and/or capture specific population characteristics across multiple regions.For example, a GIS analysis may reveal higher rates of ovarian cancer in some areas of the country, potentially linked to environmental exposures or lifestyle behaviors.Based on this information, policymakers or community leaders can implement interventions such as increasing access to screening and education on risk reduction strategies at a national level.

Figure 1 .
Figure 1.The process of choosing the best-fit normality transform for the input data.

Figure 5 .
Figure 5.The results of using a linear regression model to study the effect of multiple demographic, socioeconomic, and other factors on overall cancer mortality in the University of Chicago Medicine Comprehensive Cancer Center service area.Feature Importance scores are the percent contribution to the linear regression model.

Table 1 .
Pearson's correlation analysis results between cervical cancer mortality and the poverty rate.

Table 2 .
Pearson's correlation analysis results after removing potential confounders.

Table 3 .
Multivariate analysis results between cervical cancer mortality rate, poverty rate, and potential confounders.
Figure 3. Multivariate analysis between cervical cancer mortality rate, poverty rate, and potential confounders.

Table 4 .
The results of using a linear regression model to study the effect of multiple demographic, socioeconomic, and other factors on overall cancer mortality in the University of Chicago Medicine Comprehensive Cancer Center service area.