Eating habits and the desire to eat healthier among patients with chronic pain: a registry-based study

Healthcare professionals often meet pain patients with a poor nutritional status such as obesity, unhealthy dietary behaviors, and a suboptimal dietary intake. A poor nutritional status may play a significant role in the occurrence, development, and prognosis of chronic pain. This study investigated eating habits in a specialized pain rehabilitation center using data (N = 2152) from the Swedish quality registry for pain rehabilitation during the period 2016–2021. Patients answered a lifestyle questionnaire regarding their eating habits and desire to modify their lifestyle. The mean (SD) patient age was 46.1 (14.6) years, with 24.8% classified as obese. Suboptimal eating habits included irregular mealtimes (27.2%), weekly consumption of fast-food (20.3%) and nearly daily consumption of confectionery (33.3%). Approximately 20% (n = 426) reported a desire to eat healthier. Frequent confectionery intake (Odds ratio [OR] 1.23, 95% Confidence Interval (CI) 1.04–1.47) and fast-food consumption (OR 1.58, 95% CI 1.24–2.02) increased the likelihood to desire healthier eating. Younger patients (18–29 years), those classified as obese, and those with more extended spatial pain were more likely to express a desire to eat healthier. Eating habits should be addressed in pain management and interdisciplinary pain rehabilitation teams are encouraged to provide nutritional care tailored to the patient's needs.

www.nature.com/scientificreports/foods and excessive consumption of energy-dense, nutrient-poor processed foods is associated with poorer health outcomes 21 .In western societies, individuals' eating behaviors are challenged by convenient and ultra-processed foods that are typically low in nutritional value, thereby lowering diet quality.
Understanding patients' eating behaviors is crucial in informing interventions [22][23][24] .Various factors, including socio-demographics, attitudes toward food and health, psychological status, and social and environmental influences, can impact diet quality, eating habits and the desire to change behaviors [24][25][26] .Many studies have highlighted the prevalence of poor nutrition among individuals with chronic pain.For instance, a clinical audit of patients attending a chronic pain service in Australia revealed that most patients had a suboptimal diet quality score, indicating a need for dietary improvement 27 .Other studies have reported low fruit and vegetable intake and excessive consumption of unhealthy fats among individuals with chronic pain 28,29 .
Despite this growing body of evidence, there is a lack of any recent, large-scale surveys investigating eating habits among patients with chronic pain, particularly those that have been conducted in a clinical setting.To address this gap, our study aimed to investigate the eating habits and explore factors associated with the desire to adopt healthier dietary behaviors among individuals with complex chronic pain 30 referred to a specialized pain rehabilitation center in Sweden.By examining eating patterns and factors influencing patients' motivation to make healthier dietary choices, healthcare professionals can tailor rehabilitation goals and content to provide patient-centered care 31,32 .

Subjects
The study included patients referred from primary care or other specialist care (e.g.orthopedics, rheumatology) in the Östergötland County to the specialized Pain and Rehabilitation Centre, Linköping University Hospital between August 2016, and December 2021.Common chronic pain diagnoses were widespread pain including fibromyalgia, neck pain, lower back pain and hypermobile Ehler-Danlos syndrome.At a specialist care level, patients had non-malignant chronic pain (≥ 3 months) with complex clinical presentations including psychosocial stress.Common psychosocial stresses include anxiety, depression, and social isolation.Patients also frequently presented with physical and/or functional impairment impacting their ability to work and contribute to society.

Swedish quality registry for pain rehabilitation (SQRP)
The Swedish quality registry for pain rehabilitation (SQRP) was established in 1995, collecting patient-reported data on socio-demographics, pain aspects, psychometric data, physical disability, and quality of life 33,34 .Several self-administered questionnaires (see below) have been included in parallel with the development of pain research, for example, data on body weight and insomnia were included in 2016 35,36 .Pain and Rehabilitation Centre, Linköping University Hospital is one of the 42 pain-rehabilitation clinics (> 90% pain clinics or units) that collect SQRP data in Sweden.Approximately two weeks prior to their first consultation with a physician, patients received a postal letter with these questionnaires, and were asked to complete them before their appointment.Written and signed informed consent was obtained for SQRP data collection.The questionnaire is a mandatory clinical tool, however approximately 10% of patients do not sign consent or return to the questionnaire and therefore their data is not included in the registry.Based on our clinical experience, this may be due to language barriers, low health literacy or cognitive impairment.An administrator in the department transferred the data into a local database with a software program provided by the registry.The variables and instruments included in the questionnaires were mandatory for the clinical specialist departments registering their data with the SQRP.SQRP also collects data from patients at other timepoints during the rehabilitation periods.For this study, we only investigated the data that was collected prior to the patient's consultation with a physician (i.e.baseline data, N = 2152).

Ethics
Verbal and written information about this study using SQRP data was given to all the participants and written informed consent was thereafter obtained from all the participants.The study was conducted in accordance with the Helsinki Declaration.The study was approved by the Swedish Ethical Review Authority (dnr: 2021-02811).

Background factors
Socio-demographic factors such as gender, age (years), country of origin (Sweden, Nordic, European or other), and education (primary school, secondary school, or university/college) were extracted from SQRP.Economic status was determined based on the specific item from the Life Satisfaction questionnaire LiSAT-11.This captured the patient's perceived satisfaction with the economy (LiSAT-economy) 37 .Six possible answers were given: 1 = very dissatisfying; 2 = dissatisfying; 3 = fairly dissatisfying; 4 = fairly satisfying; 5 = satisfying; and 6 = very satisfying.

Pain characteristics
Pain intensity was defined as the average pain intensity during the previous week using a numeric rating scale from 0 to 10; 0 being no pain and 10 being the worst pain imaginable.
Patients reported the date when they first started experiencing their current pain.Pain duration was then calculated based on this date and the number of years since the onset of pain.The variable was also coded as a binary variable (pain lasting for 5 years or more = 1, pain lasting less than 5 years = 0).Spatial pain was examined using a body map with 36 predefined anatomical areas (18 on the front and 18 on the back of the body) and patients were asked to indicate their pain locations.The number of pain locations were summarized, and this variable was denoted as the Pain Region Index (PRI) 39 .

Hospital anxiety and depression scale (HADS)
The HADS is a 14-item questionnaire to measure anxiety (HADS-A, 7 items) and depression (HADS-D, 7 items), with a higher score indicating a higher possibility of anxiety and/or depression.Levels ≥ 11 (possible range: 0-21 for each subscale) indicates a definite case for anxiety or depression.An overall score was also provided to measure emotional distress 40 .

Eating habits: dietary, tobacco, and alcohol consumption
For the identification of unhealthy lifestyle behaviors, a lifestyle questionnaire was constructed in the registry based on a report from the Swedish National Board of Health and Welfare 41 .This study included questions regarding dietary behaviors (5 items), tobacco consumption (2 items) and alcohol consumption (2 items).Dietary behaviors consisted of the following items: (1) regular mealtimes (always irregular, seldom regular, tried but not regular, usually regular, or always regular), consumption of ( 2) vegetables (at least 2-3 times per day, once per day, several times per week, or seldom/ never), ( 3) fruits (4-5 servings per day, 1-2 servings per day, sometimes, or almost never), (4) fast-foods such as pizza, kebab, hotdogs, etc. (never, seldom, 1-2 times per week, several times per week, every day), and ( 5) confectionary (never, once per week, several times per week, sometime every day, several times every day).Fruit and vegetable intake was combined to yield a total score ranging from 0 to 8. A low score indicated a low intake, and high score indicated a high intake.Tobacco use included (1) moist snuff consumption and (2) cigarette smoking.Current consumption of moist snuff and/or cigarette smoking was denoted as a tobacco user.Data on both the frequency and quantity of alcohol consumption was collected.The frequency was listed as 'every day' , '1-2 times a week' , 'every other week' , 'once a month' , or 'no drinking' .The frequency was rated on a five-point Likert scales (0 = 'no drinking and 5 = ' every day').The amount of consumption on one occasion was counted as '1-2 glasses of wine or 4 centiliters of spirits' , '2-3 glasses of wine or 8-12 centiliters of spirits' , or 'more than one bottle of wine and 12 centiliters of spirits' .A grade from 0 to 2, with higher scores indicating a higher amount consumption.Patients who desired (PD) to eat healthier were ones that selected it as a priority when they were asked whether they wanted to modify their current lifestyle and chose one or more of the following areas to prioritize: (1) healthier eating, (2) increasing physical activity, (3) achieving weight loss, (4) smoking cession, (5) decreasing alcohol consumption and ( 6) none of the above.Patients who did not desire (PND) to eat healthier were respondents who did not choose it as a priority.

Statistical analysis
All statistical analysis were performed using IBM SPSS statistics (version 28.0).Descriptive data were presented using the mean and standard deviation (Mean ± SD), the mean with 95% confidence intervals (CI), or the number with the percentage, where appropriate.The desire to eat healthier was coded as a binary variable (0 = no, 1 = yes).For comparison of patients who desired healthier eating with those who did not, the χ 2 test for categorical variables, Mann-Whitney U test for non-normally distributed ordered categorical variables and Student's t test for normally distributed variables were used.Correlation analysis between eating habits and variables of interest was performed using Spearman's Rho correlation test.A p value below 0.05 was considered statistically significant.We performed univariate and multivariate logistic regressions (likelihood ratio forward measure) to identify possible predictors for patients to desire healthier eating.The results were expressed as odd ratios (OR) with 95% confidence intervals (95% CI), indicating each predictor increased (OR > 1) or decreased (OR < 1) odds for patients to desire healthier eating.The selection criteria of explanatory variables to enter in the multivariate regression model was based on a relaxed type I error (p ≤ 0.25) in the univariate analyses 42 .Each variable was carried forward, and the variable with highest p value was removed (p < 0.05 or p ≥ 0.1 for entry or removal, respectively).The Hosmer and Lemeshow test was used to examine the goodness of fit (p > 0.05).Logistic regression analyses as default use listwise deletion to handle the missing cases.To examine if missing data can lead to biased results, we also performed a sensitivity analysis where we used multiple imputation to handle the missing data as a comparison to the results based on 'real completed cases' (see Supplementary Material).

General characteristics of the study population
As shown in Table 1 (N = 2152), many of the patients were in middle age (mean 46.1 ± 14.6, 56.8% aged 30-54 years), women (71.8%) and born in a Nordic country (84%).One in five patients had a university/college education and less than 30% were satisfied with their economic status.More than half of the patients were overweight or obese (mean BMI 27.2 ± 5.6) and reported long pain duration (≥ 5 years).One in four (24.8%) was classified as obese (BMI ≥ 30 kg/m 2 ).High pain intensity (mean NRS-7d 7.1 ± 1.8), wide pain spreading (spatial extent of pain, PRI 14.4 ± 9.0) and mild depression and/or anxiety levels (mean HADS-D 8.6 ± 4.7 and mean HADS-A 8.8 ± 5.0) were also found in this study population.Approximately one in three (32.6%)were classified as clinically emotionally distressed.In comparison to PND, PD (n = 426, 19.8%) were younger, less satisfied with economic status, had a higher BMI, longer pain duration, and reported more extended spatial experience of pain and more severe emotional distress (p < 0.001 ~ 0.05).

Eating habits and their correlations to other factors
A summary of self-reported dietary, smoking and alcohol habits is listed in Fig. 1.A little over one-quarter, 27.2%, of patients had irregular mealtimes (i.e.always irregular, seldom regular, and tried but failed to keep regular mealtimes).PD had more frequent irregular mealtimes than PND (t = − 8.01, p < 0.001) and the percent of patients having irregular mealtimes almost doubled in PD (44%) than that in PND (22.9%).Second, PD had less frequent vegetable (t = 6.94, p < 0.001) and fruit intake (t = 4.64, p < 0.001) than PND.Those who did not consume vegetables or fruit on a daily basis made up 28.4% in PD, almost doubled compared to PND (15.4%, χ 2 = 38.07,p < 0.001).Third, one in five (20.3%) reported weekly or daily fast-food consumption (1-2 times per week, several times per week or every day).One in three (33.3%) reported that they nearly daily consumed confectionary (from several times per week to several times every day).PD reported higher consumption of confectionary (t = 4.27, p < 0.001) and fast food (t = 5.97, p < 0.001) compared to PND.Fourth, only a slight significant difference was found in tobacco use between the two groups (χ 2 = 4.60, p = 0.032), that a slightly higher proportion of PD were currently smoking and/or using moist snuff.Finally, PD reported lower frequency of alcohol consumption (t = − 3.94, p < 0.001) than PND.There was no statistical difference between the two groups (t = 1.63, p = 0.052) when it came to consuming alcohol on any single occasion.A majority (71.3%) reported drinking 1-2 glasses of wine or 4 centiliters of spirits and only few patients (3.6%) reported drinking a bottle of wine and 12 centiliters of spirits on any one occasion.Some significant correlations between eating habits and other variables of interest are shown in Table 2. Given a large study population, Spearman's rho was low (|r|= 0.05 ~ 0.25), indicating weak correlations.Regularity of mealtimes was significantly correlated to pain aspects (NRS-7d, PRI, and pain duration), HADS-total and the subscales, obesity, and socio-demographic factors (age, gender, education, and LiSAT-economy).Likewise, frequency of vegetable and/or fruit intake was correlated to all variables except PRI and pain duration.Three variables -NRS-7d, age and gender-were significantly correlated to all variables of suboptimal eating habits.Table 1.Characteristics of the study population, n (%) if not otherwise stated.SD standard deviation, CI confidence interval, LiSAT life satisfaction questionnaire, BMI body mass index, NRS-7d numeric pain scale during the last 7 days, HADS hospital anxiety and depression scale, HADS-A HADS-anxiety, HADS-D HADSdepression. 1 Missing cases in the variables of interest included in the supplementary document; 2 Missing data = 6, referring to those who left the answer blank.Significant values are in bold.Through the univariate logistic regression analysis (Table 3), the desire to eat healthier was primarily related to sub-optimal eating habits such as an increased consumption of confectionary (OR 1.33, 95% CI 1.17-1.51)and fast-food (OR 1.87, 95% CI 1.54-2.26).Eating habits such as regular mealtimes and a high intake of fruit and/ or vegetables, were negatively associated with the patients' desire for healthier eating (OR 0.66-0.73,p < 0.001).This remained significant in the multivariate logistic regression model when other variables were also included.Tobacco and alcohol consumption only showed statistical significance in the univariate analysis.General characteristics were also examined in the logistic regression models.In the multivariate regression model, patients aged 18-29 years (OR 1.87, 95% CI 1.20-2.91),who fell into the obese BMI category (OR 1.37, 95% CI 1.02-1.84),and who suffered more spatial extent of pain (OR 1.02, 95% CI 1.01-1.04)were more likely to report the desire for healthier eating.In the univariate analysis, patients who dissatisfied with their personal economic status, had a long pain duration, or had high levels of emotional distress were more likely to report the desire for healthier eating However, these effects were no longer significant in the latter multivariate regression model.

Discussion
In this registry-based study at a specialized pain rehabilitation center, we identified some common suboptimal eating habits in patients with chronic pain, such as irregular mealtimes, weekly or daily consumption of confectionary and fast-food.These habits were significantly associated with the patients' desire to eat healthier.Moreover, we found that patients who were younger, fell into the obese BMI category and suffered emotional distress were more likely to desire healthier eating.These findings indicate there is a need and want for lifestyle interventions, especially nutrition support, among patients with chronic pain in a specialist pain and rehabilitation center, which seems to have been a neglected aspect in the past Interdisciplinary Pain Rehabilitation Program (IPRP) 30,43 .
In everyday clinical practice, lifestyle questionnaires can be used to identify suboptimal eating habits.In this study, we selected several items focusing on their modifiability and potential post-modification benefits.

Frequency of fastfood consumption
Tobacco Use   www.nature.com/scientificreports/For example, irregular mealtimes has been correlated with mental health issues 44 or severe gastrointestinal symptoms 45 .Regarding food choices, the questions in our questionnaire corresponded to the Nordic Dietary Recommendations (NNR) for increased intake of vegetables and fruit and limited consumption of discretionary foods and drinks 46 .The literature has identified that smoking is related to a high prevalence of chronic pain and higher pain intensity 47 .Likewise, alcohol has been reported as a common coping mechanism for people suffering from chronic pain 48 .Findings from these previous studies indicate the importance of screening eating habits.Although we reported weak correlations between pain intensity and patients' eating habits in this study population, we were aware of the complex interplay between pain intensity and other biopsychosocial factors.This should be taken into account in further research, especailly in nutritional intervention studies.Chronic pain has sometimes been regarded as a lifestyle disease in pain research 5,49 .To optimize the success of lifestyle interventions, it is necessary to address patients' needs and wants, so that the intervention aligns with their motivation and engagement and reflects patient-centered care.Our regression model suggested that the patients with suboptimal eating habits want to improve their dietary intake and habits.However, we cannot definitively conclude the reasons for their desire or understand if patients' awareness (or not) of the relationship between pain and eating habits impacted on their desire.Low health literacy is one factor that may be a potential barrier impacting patients understanding and awareness of the relationship between nutrition and chronic pain or overall health 50 .It is essential that clinicians are aware that while patients may desire change, they may not know why, or how, to change.Health care professionals are well placed to address these potential gaps using education and behavior change strategies 24 .

Amount of alcohol consumed on one occasion
Lifestyle factors have key roles in the development of chronic pain 5 .In addition to physical activity and sleep disorders which are already well addressed in pain management 51,52 , attention to nutrition support is needed 7,11 .However, there are several challenges that may prevent lifestyle change.Recent studies on patients with lower back pain showed negative results after lifestyle interventions 53,54 .The authors postulate that poor adherence may explain this outcome.Tailored and person-centered approaches in nutrition support are essential to overcome this barrier 11,12 .It is also important to identify which lifestyle factors patients want to change to optimize their motivation and help clinicians to improve future tailored IPRP targeting these patients.Some patient characteristics, such as age, BMI and emotional distress (scoring high HADS), should also be considered alongside underlying motivations (i.e.sub-optimal eating habits).To consider patients' desire about lifestyle changes is also consistent with the previous research about patients' expectation in customizing their pain rehabilitation 55 .Changing behavior and/or habits requires more than just education targeting healthy eating.Behavior change and communication strategies and techniques, such as the COM-B model (interactions of capability, opportunity, and motivation of behavior change) 56 and Healthy Conversation Skills 57,58 are essential to identify motivators and barriers that may help or hinder patients and facilitate change.Situational factors, self-regulation skills and contingencies may also be needed to target the patients' goals 24 .To optimize the success and sustainability of behavior change, it is also important to focus on the role of nutrition and pain management, rather than weight loss.This is more likely to resonate with patients and prevent the negative impacts of weight stigma and highly restrictive diets which can have serious biopsychosocial effects 59 .A one-size fits all approach is not appropriate in pain rehabilitation.Nutrition assessments are required so that dietitians and health professionals can identify areas where a patient can improve their eating habits.This also allows dietitians to target personalized nutrition advice and strategies.During this process, by using behavior change communication strategies, the dietitian or health professional can also determine the patient's willingness to change their eating habits.This should be included when tailoring IPRP for patients.
To the best of our knowledge, this study is the first to present eating habits among patients referred to pain rehabilitation clinics at specialist care.The novelty of this study is that we collected clinical data to address important lifestyle factors, which seems to be overlooked in chronic pain management.Using registry data with a large sample size, enabled us to provide practice-based evidence in pain and rehabilitation research.When patients filled out the questionnaires, they did not receive any motivational interviewing or education about nutrition's role in pain management.Their sub-optimal eating habits and the desire for healthier eating may encourage clinicians to address nutrition care in future pain rehabilitation.This study has several limitations.Firstly, as a cross-sectional analysis, we cannot determine the causal-effect relationship.Lifestyle change takes time and needs appropriate measurement to evaluate the possible changes during the follow-up months to years.Secondly, the study population was limited to a specialist pain and rehabilitation center and there was no control group.In Sweden, patients referred to specialist care are considered to have more complex pain conditions and our results may be generalized to this patient group at specialist care level but interpretation beyond this population is limited.Patients with chronic pain in primary care may have different eating habits.Thirdly, lifestyle factors we analyzed in this study were self-reported data and pragmatically applied in clinical practice.This lifestyle questionniare was a brief screening tool for clnical assessments and lacked definitions and serve sizes for fruit and vegetables, and fast-food.This limits the ability to calcuate the amount and type of fruit and vegetables and fast food consumed.The use of a detailed qestionnaire or further indivudal interview by dietitian or nurse in the rehabiliation team would allow more specifc data to be collected.Validation of the questions for research use should also be considered.Fourth, we did not measure patients' attitudes to food and health which can influence eating habits and the desire for behavioral change 24,25 .Patients with chronic pain may also face challenges in maintaining a healthy diet due to difficulties in shopping, meal preparation, and cooking 7 .These factors should be considered when developing future studies, especially those studies which develop, implement and test nutritional interventions for people experiencing chronic pain.
In conclusion, using real-world data and pragmatic instruments in clinical practice, we found that suboptimal eating habits were common in patients with chronic pain, such as irregular mealtimes, frequent consumption of confectionery and fast-food.Many patients reported a desire to eat healthier, highlighting the need for eating habits to be acknowledged and addressed in pain management.While patients indicated their desire to eat 14:4705 | https://doi.org/10.1038/s41598-024-55449-zwww.nature.com/scientificreports/

Figure 1 .
Figure 1.Differences of eating habits between patients who desired to eat healthier and those who did not.The X axis represents the proportion of patients' choices in each category of eating habits.Red bars show the proportion of patients who desired to eat healthier and blue bars represent patients who did not desired to eat healthier.Chi-square test, *P < 0.05, **P < 0.01.

Table 3 .
Binary 1ogistic regression (forward LR) -factors associated with patients' desire for healthier eating.Significant ORs (CIs) are given in bold.LiSAT life satisfaction questionnaire, NRS-7d numeric pain scale during the last 7 days, OR Odds ratio; CI confidence interval.Not included: variable selected in the regression model but not included in the final step via LR Forward method.Not applied: variable not selected in the regression model due to low significant level (p > 0.25) in the univariate regression model.1NagelkerkeR 2 = 0.121.Variables associated with patients'