Abstract
The impact of the pandemic on hypertension management is unknown, particularly regarding changes in demographic risk factors. We conducted a comprehensive study between 1998 and 2021 on the long-term trends in hypertension prevalence in South Korea, including a comparison of the pre-pandemic and pandemic eras. Data from 1998 to 2021 of 108,687 Korean adults were obtained through a nationwide, large-scale, and serial study. We conducted a weighted complex sampling analysis on the estimates of national prevalence and compared the slope of hypertension prevalence before and during the pandemic to determine the trend dynamics. We included 108,687 participants over 24 years, 1998–2021. While the prevalence of patients with hypertension consistently increased before the pandemic from 25.51% [95% CI: 24.27–26.75] in 1998–2005 to 27.81% [95% CI: 26.97–28.66] in 2016–2019, the increasing slope in hypertension prevalence slowed during the pandemic period (28.07% [95% CI: 26.16–29.98] for 2021; βdiff, −0.012 [−0.023 to 0.000]). Hypertension awareness, treatment, control, and control rates among patients receiving treatment followed similar trends. Compared to the pre-pandemic era, individuals aged 19–59 years or male had significantly increased control rates among the treated patients during the pandemic. This study investigated long-term trends in hypertension prevalence, awareness, treatment, and control among Korean adults. The absence of a reduction in the health indicators associated with hypertension during the pandemic implies that medical services for individuals with hypertension remain unaffected.
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Introduction
Hypertension is a leading public health concern worldwide and a major risk factor for cardiovascular diseases1. In South Korea, hypertension prevalence has been increasing steadily for several decades resulting in a significant burden on healthcare resources2. Thus, a thorough understanding of trends in hypertension prevalence, awareness, treatment, and control is crucial for developing effective prevention and control strategies3.
Furthermore, the COVID-19 pandemic has caused unprecedented disruptions to healthcare systems worldwide4,5,6. Consequently, the impact of the pandemic on hypertension management remains unclear, particularly regarding changes in demographic risk factors7. By comparing hypertension trends before and during the pandemic, it may be possible to ascertain the effect of the pandemic on hypertension management.
Thus, we aimed to present a comprehensive overview of hypertension trends in South Korea between 1998 and 2021, including a pre-pandemic and pandemic era comparison8,9. Additionally, we investigated the socioeconomic factors for hypertension in South Korea and these risk factors variations over time. Our findings will help policymakers and healthcare providers develop a focused treatment plan for hypertension management.
Method
Study population
The Korea Disease Control and Prevention Agency (KDCA) conducted the Korea National Health and Nutrition Examination Survey (KNHANES), a nationwide health information survey, using a stratified multistage probability sampling design to obtain nationally representative estimates of the Korean population10,11. Sample weights were accounted for by using primary sample units, households, and persons to ensure accurate representation. Each year, health interviews and physical examinations were conducted on a representative sample of the entire Korean civilian population10,11. Herein we utilized the KNHANES data from 1998 to 2021 to examine the trends in hypertension prevalence, awareness, treatment, control, and control among patients receiving treatment over 24 years. The study protocol was approved by the Institutional Review Board of Kyung Hee University (KHUH 2022-06-042) and the KDCA. All participants provided written informed consent. The research was carried out in accordance with the principles outlined in the Declaration of Helsinki.
We used 108,824 adults who completed hypertension evaluation; however, 137 were excluded owing to missing weight values. Thus, the final sample for data analysis included 108,687 participants at baseline, 47,062 (43.3%) men and 61,625 (56.7%) women.
Time trend
We aimed to categorize the survey periods based on the investigation phases of KNHANES10. To stabilize prevalence, we grouped the first to third phases (1998, 2001, and 2005). Additionally, for the year 2019 corresponding to the 8th phase, we integrated it with the 7th phase and separately analyzed the pandemic period. Finally, to analyze changes during the pandemic period more sensitively, we opted to dissect and analyze the years 2020 and 2021. These years segments were: 1998–2005, 2007–2009, 2010–2012, 2013–2015, 2016–2019, 2020, and 2021. Because the first COVID-19 cases in South Korea were reported on January 20, 2020, we classified 2020 as the early pandemic era and 2021 as the mid-pandemic era5,12,13.
Main outcome
The independent variables of this study were hypertension prevalence, awareness, treatment, control, and control among patients receiving treatment3. Participants were asked to self-report whether they had been previously diagnosed with hypertension. Subjects rested for over 5 min by sitting, and then the researcher allowed the subjects to properly place the cuff on their arm circumference. Blood pressure was measured using a Baumanometer Wall Unit 33 (mercury sphygmomanometer) from 1998 to 2019, Greenlight 300 (mercury-free auscultatory device) in 2020, and Microlife WatchBP Office AFIB (mercury-free automated blood pressure device) in 202114. The researcher checked the participant's blood pressure two to three times on their right arm. We used the second value or the average of the second and third value of blood pressure for the study. Hypertension was classified as a systolic blood pressure of ≥ 140 mm Hg or a diastolic blood pressure of ≥ 90 mm Hg or being on medication for hypertension3. Awareness was determined by the percentage of participants with hypertension who answered "Yes" to the question, "Have you ever been told by a doctor or other healthcare professional that you had high blood pressure?"3. Although the guideline of the KNHANES analysis suggested that treatment is defined as the percentage of participants with hypertension who reported receiving more than 20 days of prescribed antihypertensive medication for its management, there was no detailed question about frequency between 1998 and 2005. To ensure consistent analysis, we have defined treatment as follows. Treatment was calculated as the percentage of participants with hypertension who reported receiving at least one prescribed antihypertensive drug for the management of hypertension3. Control was calculated as the percentage of participants with hypertension who had a systolic blood pressure < 140 mm Hg and a diastolic blood pressure < 90 mm Hg during the survey measurements. Control among those receiving treatment refers to individuals who are taking medication for hypertension and have a systolic blood pressure < 140 mm Hg and a diastolic blood pressure < 90 mm Hg as determined through measurements obtained during the survey.
Covariates
The variables included in the analysis were sex, age (19–29, 30–39, 40–49, 50–59, 60–69, 70–79, and ≥ 80 years), region of residence (urban and rural)15, body mass index group (normal or underweight [< 23.0 kg/m2], overweight [23.0–25.0 kg/m2], obese [≥ 25.0 kg/m2], and unknown), central obesity (unknown, yes, and no), household income (unknown, lowest, second, third, and highest quartile), education background (elementary school or lower, middle school, high school, and college or higher), alcohol consumption (1–3 and ≥ 4 times a week and non-drinker), and smoking status (non-smoker, ex-smoker, and smoker). Central obesity was defined as having a waist circumference of ≥ 90 cm for men and ≥ 85 cm for women3.
Statistical analysis
We conducted a weighted complex sampling analysis to examine the estimates of national hypertension prevalence, awareness, treatment, and control among those receiving treatment. We used the weights to calculate the crude rate. In addition, the age-standardized prevalence rates for hypertension were estimated. We utilized weighted linear regression models to examine the trend of hypertension prevalence, awareness, treatment, control, and control among patients receiving treatment over the last 24 years, focusing on the period during the COVID-19 outbreak16. A difference of β (βdiff) and 95% confidence interval (CI) was analyzed to examine the trend changes between 1998 and 2019 vs. 2020–2021 (before vs. during the pandemic)5,12,17,18. Additionally, we utilized weighted logistic regression models to obtain the weighted odds ratios (ORs) and 95% CI between 1998 to 2019 versus 2020 to 2021. We performed a stratification analysis by sex, educational background, region of residence, and income through all weighted linear and logistic regression models to confirm our main findings. We calculated the ratio of ORs to estimate the interaction term of each risk factor, which allowed us to identify which groups were more vulnerable to the prevalence of diagnosed hypertension and more likely to have awareness, treatment, control, and control among patients receiving treatment during the pandemic. To robust the hypothesis, we analyzed βdiff and ORs by a single year between 2016 to 2019 versus 2020 to 2020.
All statistical analyses were performed using the SAS software (version 9.4; SAS Institute, Cary, NC, USA). We used a two-sided test and considered p-values < 0.05 statistically significant.
Results
Over 24 years, between 1998 and 2021, a comprehensive examination of the KNHANES included 108,687 participants. Table 1 shows the demographic and baseline characteristics of the participants. Of the total participants (mean age 49.97 [standard deviation, 16.78] years), 47,062 (43.3%) were men, whereas 61,625 (56.7%) were women.
Table 2 shows the weighted crude prevalence, awareness, treatment, control, and control among patients receiving treatment stratified by factor groups over 24 years and the trends before and during the COVID-19 pandemic.
Prevalence of hypertension
The study found that there was a statistically significant increase in the weighted prevalence of hypertension from 25.51% (95% CI: 24.27–26.75) to 28.07% (95% CI: 26.16–29.98) between 1998 and 2021 (Table 2 and Table S1–S14). However, the prevalence of hypertension did not increase significantly from the new onset of the pandemic to 2021. Regarding sex differences, the prevalence of hypertension significantly increased in men during the pandemic compared to the pre-pandemic era of 2016–2019 (Table S15 and S16). However, no significant differences were observed in the age group, residence, educational background, or income categories. Table 3 shows the odds ratios (95% CI) and coefficients of hypertension prevalence, awareness, treatment, control, and control among patients receiving treatment during the pre- and pandemic eras. Before the pandemic, the prevalence of hypertension consistently increased between 1998 and 2019. However, the increase in the prevalence of hypertension showed a decrease during the pandemic period compared to the pre-pandemic era (βdiff, −0.012; 95% CI: −0.023 to 0.000, p-value < 0.05). This trend was observed in urban areas and across different levels of education (Fig. 1).
Hypertension awareness, treatment, control, and control among patients receiving treatment
The weighted crude rate of awareness steadily increased from 43.41% (95% CI: 41.17–45.65) to 68.08% (95% CI: 66.66–69.50) before the pandemic (1998–2019) and further improved to 74.08% (95% CI: 71.34–76.81) in 2021. The weighted crude rate of treatment also increased from 38.69% (95% CI: 36.55–40.83) to 64.92% (95% CI: 63.44–66.40) before the pandemic and further improved to 71.19% (95% CI: 68.38–74.01) in 2021. The control rate rose from 17.81% (95% CI: 16.08–19.54) to 47.21% (95% CI: 45.65–48.76) pre-pandemic and subsequently improved to 56.00% (95% CI: 53.09–58.91) in 2021. The proportion of control among the treated population increased from 46.04% (95% CI: 42.70–49.37) to 72.72% (95% CI: 71.18–74.25) before the pandemic and further improved to 78.65% (95% CI: 76.16–81.15) in 2021. During the pandemic, the proportion of controls among the treated population increased, and awareness and treatment rates remained high. The rates of hypertension awareness, treatment, control, and control among patients receiving treatment showed a consistent increase between 1998 and 2019, before the pandemic. However, these indicators increased at a slower pace during the pandemic, as compared to the pre-pandemic era (βdiff for awareness, −0.044; 95% CI: [−0.061] to [−0.028], βdiff for treatment, −0.017; 95% CI: [−0.034] to [0.000], βdiff for control, −0.067; 95% CI: [−0.085] to [−0.049], and βdiff for control among treated individuals, −0.012; 95% CI: [−0.029] to [0.005]).
When comparing the pre-pandemic era (2016–2019) to the pandemic era, no significant odds ratios were observed for prevalence, awareness, treatment, control, and control among patients receiving treatment, except for men, who showed a significant odds ratio for the prevalence of hypertension (Table S6). However, during the pandemic era, there were significant increases in hypertension awareness, treatment, control, and control among patients receiving treatment. Regarding health indices, the odds ratios for awareness, treatment, control, and control among patients receiving treatment differed significantly between the first and late pandemic eras. Nevertheless, no significant odds ratios were observed for the prevalence of hypertension during the pandemic era compared with the pre-pandemic era or between the first and late pandemic eras.
Socioeconomic factors
Table 4 shows the odds ratios between the pre-COVID-19 and COVID-19 pandemics to identify any changes in risk factors during the pandemic era. The risk factors for hypertension were sex (male), older age (> 60 years), residence in rural areas, lower educational status (high school or lower), and higher income (third or highest quartile). No significant differences were observed in socioeconomic factors between the pre-pandemic and pandemic eras. Specifically, men had significantly higher rates of hypertension awareness, treatment, and control among patients receiving treatment during the pandemic compared to the pre-pandemic era. Additionally, individuals aged 19–59 years had significantly higher control rates and control among the treatment group during the pandemic era.
Discussion
Key findings
To the best of our knowledge, this is the first study to investigate the long-term trends and the potential impact of the COVID-19 pandemic on hypertension prevalence, awareness, treatment, and control, and its associated socioeconomic factors in South Korea (n = 108,687). We found that the hypertension prevalence increased throughout the pre-pandemic era; however, the increase in hypertension prevalence slowed during the pandemic era. The trends in hypertension awareness, treatment, control, and control among patients receiving treatment were similar. Young adults or men (19–59 years) were recognized as being more likely to benefit clinically after the pandemic era. Suggestions regarding the political implications of a clinical plan that considers hypertension prevalence, awareness, treatment, and control could be necessary based on our analysis of comparison to the COVID-19 pandemic era.
Comparison with previous studies
Initially, investigations regarding the prevalence, awareness, treatment, control, and control among patients receiving treatment and its associated socioeconomic factors were not conducted in the specific context of the COVID-19 pandemic. Our research spans 24 years and aims to provide long-term insights. Prior studies have thoroughly investigated the relationship between hypertension and mortality rates during the COVID-19 pandemic or only the prevalence of hypertension. However, our focus had been on analyzing the patterns of health indicators associated with hypertension prevalence, awareness, treatment, control, and control among patients receiving treatment19,20,21,22. Our findings were consistent with previous research on the prevalence, awareness, treatment, control, and control among patients receiving treatment8,23.
Previous studies have identified various sociodemographic factors for hypertension, but none have examined these factors in the context of the COVID-19 pandemic24,25. A previous study reported that individuals > 60 years, men, and those with lower education and income levels were at a greater risk of hypertension3,26. However, it is imperative to note that these risk factors remained consistent during the pandemic era. Nevertheless, there may have been some differences in health indices associated with hypertension during this period.
Possible mechanisms
Men and young adults may have had better hypertension control and treatment rates during this period for several reasons. First, the pandemic has led to an increased focus on public health and preventive measures, including managing chronic conditions such as hypertension27. The pandemic has heightened awareness of the significance of health. Individuals with chronic ailments, like hypertension, may be more inclined to manage their overall well-being diligently. As a result, there may be increased awareness among men and young adults regarding the importance of hypertension control and treatment, leading to better adherence to medication and lifestyle modifications. Second, telemedicine and remote monitoring have become more common during the pandemic28, making it easier for men and young adults to receive hypertension treatment and monitoring from the safety of their homes29. During the pandemic, healthcare organizations increased their use of in-person care, facilitating hypertension patients' access to healthcare and potentially improving blood pressure management. This may have led to increased access to healthcare and improved hypertension control and management30. Furthermore, the pandemic and lifestyle changes, such as reduced stress levels due to remote work or reduced commuting time, can positively impact hypertension control and treatment outcomes31. During the pandemic, individuals have been spending more time in their homes, potentially creating an environment that promotes a focus on health. The decrease in outdoor activities and increase in home-based routines may have contributed to this heightened awareness. For instance, implementing healthy meal choices or engaging in routine exercise may positively affect blood pressure management. Additionally, During the pandemic, there has been a significant improvement in the accessibility of health information through online platforms32. This has allowed patients to easily access vital information and gain a better understanding of their condition, which may have enabled them to adopt necessary lifestyle changes to manage their blood pressure effectively.
Policy implications
Based on our study, the Korean clinical system effectively maintained health indices related to hypertension during the pandemic33. Further research should be conducted to better understand this clinical system. Additionally, this clinical system should be considered for treating morbidities other than hypertension. Behaviors of young adults and men aged 19–59 years should be analyzed to develop interventions that can be applied to all patients with hypertension as they showed higher performance regarding health indices related to hypertension. This can lead to significant improvements in the treatment and management of hypertension, although its incidence cannot be prevented. Based on our understanding of the existing clinical system, we must not ignore any potential weaknesses in the clinical infrastructure in preparation for future pandemic eras.
During the COVID-19 pandemic, we observed a deceleration in the rate of hypertension prevalence increase. This finding implies that preventative healthcare strategies and hypertension management policies can be successfully sustained even amidst a pandemic. Therefore, other nations can mitigate the negative impact of the COVID-19 crisis by implementing and promoting policies and initiatives aimed at enhancing hypertension prevention and management.
Strengths and limitations
Our study has several strengths, including a large sample size, representative data from the Korean population, a comprehensive investigation of 24-year trends and risk factors in hypertension prevalence, awareness, treatment, and control, and a comparison between the pre- and COVID-19 pandemic eras. However, our study has some limitations. First, regardless of the length of treatment, the definition of hypertension treatment has changed over time, encompassing patients receiving antihypertensive medication. This inconsistency in the description of treatment across different periods in the KNHANES might have led to an overestimation of the rate of hypertension treatment from 1998 to 2005. Despite the potential limitations of our study, the overall impact on the trend is anticipated to be minimal, given the consistency of the definitions used in the latter periods and the absence of significant gaps in the existing literature. Furthermore, although our investigation centers on a pandemic with a relatively brief duration, it can serve as a viable surrogate for future research. Our research examined socioeconomic demographic changes over 24 years, including significant urbanization34. Thus, while our findings may not provide a definitive understanding of the trend, they have great academic value due to the duration of our study. To accurately reflect the actual trend, we treated non-responses to the questionnaire or “unknown” responses as negative responses, which had a negligible impact on the results and did not create any noticeable limitations.
Conclusions
This study investigated long-term trends in the prevalence of hypertension and its related awareness, treatment, and control among Korean adults. We found that the prevalence of hypertension increased before the pandemic but slowed during the pandemic. The prevalence of hypertension was the highest in 2021, with rates of awareness, treatment, and control following a similar trend. This study suggests that young adults and men should receive clinical benefits after the pandemic. The absence of a reduction in the health indicators associated with hypertension during the pandemic implies that medical services for individuals with hypertension remain unaffected. Furthermore, the increase in health indices indicated that the Korean clinical system was effectively activated during the pandemic.
Data availability
Data are available on reasonable request. Study protocol, statistical code: available from DKY (email: yonkkang@gmail.com). Data set: available from the Korea Disease Control and Prevention Agency (KDCA) through a data use agreement.
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Funding
This research was supported by grants from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (grant number: HE23C002800) and from the Ministry of Food and Drug Safety (grant number: 21153MFDS601) in 2023. The funders had no role in study design, data collection, data analysis, data interpretation, or writing of the report.
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D.K.Y. had full access to all of the data in the study and took responsibility for the integrity of the data and the accuracy of the data analysis. All authors approved the final version before submission. Study concept and design: M.L. and D.K.Y.; Acquisition, analysis, or interpretation of data: M.L. and D.K.Y.; Drafting of the manuscript: M.L. and D.K.Y.; Critical revision of the manuscript for important intellectual content: all authors; Statistical analysis: M.L. and D.K.Y.; Study supervision: M.R., S.Y.R., and D.K.Y. D.K.Y. supervised the study and is guarantor for this study. The corresponding author attests that all listed authors meet authorship criteria and that no others meeting the criteria have been omitted.
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Lee, M., Lee, H., Park, J. et al. Trends in hypertension prevalence, awareness, treatment, and control in South Korea, 1998–2021: a nationally representative serial study. Sci Rep 13, 21724 (2023). https://doi.org/10.1038/s41598-023-49055-8
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DOI: https://doi.org/10.1038/s41598-023-49055-8