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Partial oxidation of methane to methanol on boron nitride at near critical acetonitrile

Abstract

Direct catalytic conversion of methane to methanol with O2 has been a fundamental challenge in unlocking abundant natural gas supplies. Metal-free methane conversion with 17% methanol yield based on the limiting reagent O2 at 275 °C was achieved with near supercritical acetonitrile in the presence of boron nitride. Reaction temperature, catalyst loading, dwell time, methane–oxygen molar ratio, and solvent-oxygen molar ratios were identified as critical factors controlling methane activation and the methanol yield. Extension of the study to ethane (C2) showed moderate yields of methanol (3.6%) and ethanol (4.5%).

Introduction

Indirect, high temperature (600–1100 °C) steam reforming coupled with high pressure (400–800 psi) syngas conversion using Cu/ZnO/Al2O3 catalysts afford methanol1. Direct partial oxidation at mild temperatures (< 450 °C) are afforded as two main strategies used in conversion of methane to methanol2,3,4,5. Oxidation of methane to methanol using O2 and H2 is known to produce methanol in water6,7,8,9,10. Even though the direct partial oxidation of methane is thermodynamically feasible, the overoxidation of subsequent products such as methanol, formaldehyde and formic acid to CO2 have less activation barrier than activation of methane11,12,13.

In the direct route, a trade-off between methane bond activation (Ea 175 kJ/mol on Cu(111)) and product (methanol and other oxygenates) protection (methanol has ~ 50 kJ/mol lower bond C–H dissociation energy than methane) against overoxidation govern the overall yield of methanol3,11,14. Based on the above concept, Nørskov et al. recently established a mathematical model11 to explain the reason for low methanol yields (< 1%) despite years of research. This model recognizes solvation free energy (SFE) modification of methanol as one approach to improve product yield by decreasing the activation free energy difference between methane and methanol (product protection). Similarly, minimization of mass transfer limitations (MTL) in conventional homogenous catalytic systems which arise due to limited solubility of oxygen and methane, may lead to improved methanol yields (methane activation). These low solubility and mass transfer limitations can be avoided by going into a supercritical or near critical phase. Unusual selectivities were previously observed by Debendetti et al.15 for toluene disproportionation over ZSM-5 that was ascribed to near critical clustering. The authors hypothesized the near critical clustering of toluene resulted in more surface reactions as the diffusion inside the zeolite pores was reduced. For two phase reaction systems, the near critical clustering phenomenon is not hitherto explored. We have studied a number of two phase systems comprising of solvents such as CO216 and acetonitrile. We observed acetonitrile-O2 based system showed unusual changes in reaction selectivity for partial oxidation of methane above the critical point of acetonitrile.

Savage et al. studied methane to methanol and methanol overoxidation reactions in near and supercritical (NSC and SC) water17,18,19. Water at critical conditions behaves similarly to a nonpolar solvent with higher methane and oxygen solubility which could relax the aforementioned MTL during the reaction20. If insignificant MTL are assumed, the bulk could be enriched with methane and oxygen which sets conditions for the overoxidation reaction. We have explored a number of super critical and near critical solvent systems (Supplementary Table S1 for scCO2, FCH2CN, Cl3CCN, water, benzene). We observed unusual selectivity of methanol formation at short residence times with weakly hydrogen bonding nitrile solvents. Weak hydrogen bonding aprotic solvents such as acetonitrile can form molecular clusters at critical conditions which can act as localized reaction pockets isolated from the bulk21,22.

Even though SC solvents (e.g. water) can activate methane23,24, introduction of secondary activators may be required to improve the product yield25. Oxidative dehydrogenation, selective oxidation, and the coupling ability of boron based catalysts such as borocarbonnitrides26,27,28 and hexagonal boron nitride (h-BN)29,30,31 have been previously utilized in C1–C4 hydrocarbon to olefin conversion reactions. Although the C–H bond, molecular oxygen activation ability, and low carbon dioxide selectivity of B2O3 has been studied32, using h-BN have not been exploited in methane to methanol conversion reactions under SC conditions. In summary, SC solvent could minimize MTL (solubility), control local methane/oxygen concentrations (clustering), activate methane/oxygen, and protect methanol against overoxidation (clustering, SFE) while methanol formed on h-BN can be protected by SFE modification and controlled local oxygen concentration inside the cluster. Synergetic effects between modulation of local molecular concentrations by SC (275 °C, ~ 4000 psi) acetonitrile clusters to avoid the overoxidation reaction and methane activation by h-BN have been investigated in this study.

Experimental

Materials

All experiments were carried out in a 50 mL high-pressure (max 5000 psi) reactor model A3240HC6EB (Parr Instruments, Moline, IL) utilized with reactor controller 4848. The reactor controller was operated in the PID controlling mode and the rotor was at the highest rotation speed of 60 rpm. The system pressure and temperature were continuously digitally monitored with the associated software. All reactant gases including ultra-purity nitrogen, helium, oxygen, methane, ethane, carbon dioxide, and propane were purchased from Airgas, Inc, North Franklin, CT. Graphite, h-BN, acetonitrile, fluoroacetonitrile, trichloroacetonitrile, deuterated acetonitrile, and copper perchlorate hexahydrate were purchased from Sigma Aldrich. Liquid reactants were introduced with a 1000 μL micropipette (one-time use tips) and sampling was carried out with the help of single-use sterilized syringes and PTFE microfilters.

Method

In a typical reaction, solvent and catalyst were loaded to the reactor. The reactor was cooled down to − 30 °C with liquid nitrogen and pressurized with the calculated amounts of O2, CH4, and inert gas (N2 or He) while the temperature was stable at − 30 °C. Then the reactor was heated to the precalculated (to avoid explosion range) temperature with a ramp rate of 2.5 °C/min (PID) and maintained there for the desired dwelling time. The reactor was then cooled down to ambient temperature by natural convection. Products were analyzed by GC–MS and NMR to determine the methanol concentration. Product mixtures were extracted with a single-use sterilized syringe and filtered with 0.22 μm PTFE microfilters. The complete reactor flow diagram can be found in Fig. 1.

Figure 1
figure 1

High-pressure reactor and setup design equipped with Parr 4848 reactor controller.

Methanol and CO2 yield, and selectivity were calculated using following formulas (assuming CO2 is the only by product formed),

$$\text{Methanol yield CH}_{4}\text{ based }= \frac{moles\, of \,methanol}{moles\, of\, methane}\times 100\%,$$
$$\text{Methanol yield O}_{2}\text{ based }= \frac{moles\, of\, methanol}{moles\, of\, oxygen\times 2}\times 100\%,$$
$$\text{Methanol \,selectivity }= \frac{moles \,of\, methanol}{moles \,of\, methane\, reacted}\times 100\%,$$
$${\text{CO}}_{2}\,\text{ selectivity }=\frac{moles\, of \,\text{CO}2}{moles \,of\, methane\, reacted}\times 100\%,$$
$${\text{O}}_{2}\,\text{ conversion }=\frac{(moles \,of \,methanol+moles \,of\, \text{CO}2\times 2)}{moles\, of \,oxygen\times 2}\times 100\%.$$

Results

Optimization of the reaction parameters

Optimization of methane:oxygen molar ratio

The methane to oxygen molar ratio was systematically increased by increasing methane and decreasing oxygen amounts to validate the product overoxidation hypothesis as shown in Fig. 2. An increase in the oxygen-based methanol yield from 0.1 to 5.2% was noticed as the methane/oxygen molar ratio was increased from 0.5 to 16.8. Even at lower oxygen (3 mmol) amounts, higher methanol yield (4.7%) was noticed. A significant increase (27%) in the methanol yield was noticed when the methane amount was maintained at a constant (118 mmol) value and the oxygen amount was decreased from 13.5 to 7 mmol, see Fig. 2 experiments 3 and 4. The increase in the yield was linear up to the molar ratio of 8.7 and then the yield started to fall at higher ratios. When the ratio was at 60, a decrease in the methanol yield to 4.7% was observed.

Figure 2
figure 2

The effect of methane to oxygen ratio on direct methane oxidation to methanol in near supercritical acetonitrile. All entries were conducted with 3 mL (57 mmol) of acetonitrile loaded into the reactor and cold fed (− 30 °C) with desired molar amounts of O2, CH4, and He. The reactor was heated with a ramp rate of ~ 2.5 °C/min up to 275 °C and the heater was programmed to switch off at 275 °C. A 60 rpm stirring speed was used. The samples were cooled to ambient temperature at the natural convection rate. Standard deviation (S. D.) was based on deviation in loading pressure. Methanol yield was calculated based on gas chromatography (GC) peak area calibration plots and reconfirmed with nuclear magnetic resonance (NMR) studies. The standard deviation of the yield was calculated by replicating one experiment and comparison with NMR data.

The headspace gas analysis of the reactor after the reaction showed only CO, CO2 permanent gases as shown in Figs. S5 and S6.

Optimization of the temperature

The effect of temperature on methanol yield was studied by maintaining an optimum methane/oxygen ratio of 16.8 and without any dwell time as shown in Table 1. An increase in the oxygen-based methanol yield from 0.3 to 6.6% was noticed when the reaction temperature was increased from 250 to 300 °C. The lowest carbon dioxide selectivity was observed when the reaction was performed at 275 °C. A 25 °C higher or lower reaction temperature than 275 °C resulted in higher carbon dioxide selectivity. The optimal reaction temperature was selected as 275 °C for the rest of the study.

Table 1 The effect of temperature on direct methane oxidation to methanol in near supercritical acetonitrile.

Effects of different supercritical solvents and optimization of acetonitrile:oxygen molar ratio

Effects of different solvents on methane activation were studied as shown in Table S1. The molar ratio and solvent volume have been adjusted to avoid the flammability range of methane. Even though a direct comparison cannot be attained due to changes in conditions, a general idea about the reactivity trend can be obtained from these experiments. The methanol yield was halved (2.7%) when deuterated acetonitrile was used instead of non-deuterated acetonitrile (5.3%). Low methanol yield (1%) compared to deuterated or non-deuterated acetonitrile was noticed when a trichloroacetonitrile rich acetonitrile mixture was used in the reaction. Low methanol yields, 5% and 0.4%, were noticed when reactions were performed with conventional supercritical solvents such as carbon dioxide and water. The lowest methanol yield (0.04%) was observed in apolar solvent benzene as compared to other solvents.

The methane/oxygen molar ratio (same amount of methane and oxygen) was held constant at the optimum value (~ 17) while changing the acetonitrile content in the system at 275 °C as shown in Fig. 3. A linear increase in the methanol yield (O2 based) from 0.2 to 4.6% was noticed as the solvent to oxygen molar ratio was increased from 1.3 to 8.

Figure 3
figure 3

The effect of acetonitrile to oxygen molar ratio on direct methane oxidation to methanol in near supercritical acetonitrile. 9.5–95.7 mmol acetonitrile, − 30 °C cold feed, 163 mmol He, 120–124 mmol methane, 7.3–7.4 mmol of oxygen (without h-BN). All entries were carried out at 275 °C with 2.5 °C/min ramp rate, zero dwell time, and natural cooling to room temperature, 60 rpm stirring speed. Methanol yield was calculated based on the GC peak area calibration plot and reconfirmed with NMR. The standard deviation of the yield was calculated by replicating one experiment with comparison to NMR data.

Effects of different nitrides, stirring and optimization of h-BN:oxygen molar ratio

After optimizing the acetonitrile only conditions, h-BN was introduced into the system to investigate synergetic effects. A 70% (from 4.6 yield) increase in the methanol yield was observed when 1.15: 1 h-BN: oxygen molar ratio of hexagonal boron nitride was used as a catalyst (Table 1). Relatively low methanol yields were observed in the presence of other nitrides (Supplementary Table S2) including C3N4 (0.4%), InN (1.7%), and TiN (0.8%). A relationship between the system stirring and the methanol yield was observed as shown in Supplementary Table S3. The methanol yield was increased by 50% upon stirring the system at 60 rpm compared to the non-stirring system. A methanol yield of 3%, lower than the acetonitrile only yield (5.2%), was noticed even in the absence of acetonitrile and in the presence of h-BN. A 118% increase in the methanol yield was identified upon increasing the boron nitride loading to 2.30: 1 h-BN: oxygen molar ratio. A steady decrease in the methanol yield was observed when the boron nitride loading was increased from 2.30: 1 to 4.60: 1 (h-BN: oxygen molar ratio) as shown in Fig. 4. Both oxygen and methane-based methanol yields are depicted for comparison to the literature. A maximum oxygen-based methanol yield of 17.3% and methane-based yield of 2.0% were observed at 2.30: 1 h-BN to oxygen molar loading. Use of an oxygen-based yield can be justified by considering the limited oxygen (1: 17; oxygen: methane) amount in this study.

Figure 4
figure 4

Variation of oxygen and methane-based methanol yield with different boron nitride loading. All runs were conducted with the specified amount of h-BN, 118 mmol of CH4, 7 mmol of O2, 163 mmol of He, 57 mmol acetonitrile heated up to 275 °C, no dwell time, 60 rpm stirring.

Optimization of acetonitrile:oxygen molar ratio with h-BN

The acetonitrile to oxygen ratio was changed in the presence of h-BN initiator as shown in Fig. 5. A linear increase in the oxygen-based methanol yield with (up to the ratio of 2) or without h-BN was observed with an increase in the acetonitrile to oxygen ratio. At ratios higher than 2, a different trend was observed with 2.30: 1 h-BN: oxygen molar ratio. When the ratio is at 8.2 the highest methanol yield was observed with or without h-BN.

Figure 5
figure 5

Variation of O2 based methanol yield with acetonitrile: O2 ratio and boron nitride loading. The graph does not illustrate 2.30: 1 h-BN to oxygen molar ratio, 8.2 MeCN: O2 ratio reaction which resulted in 17% yield. All runs were conducted with the specified amount of BN, cold feed; 118 mmol of CH4, 7 mmol of O2, 163 mmol of He. The amount of acetonitrile was varied (0 mmol, 19 mmol, 28 mmol, 57 mmol, 76 mmol, 95 mmol) and heated to 275 °C, with no dwell time, and 60 rpm stirring.

Effect of h-BN loaded on different supports

h-BN was loaded on different supports including Al2O3, graphite, SiO2, and TiO2 using a borane-amine adduct based incipient wetness impregnation method to check the effect on selectivity of the products formed and to increase the surface area of h-BN. Low methanol yields, 0.06 and 0.02% were observed when BN was loaded on γ-Al2O3 and TiO2 respectively. When BN was loaded on silica or graphite, higher methanol yields were observed (3.6% and 3.9% respectively) as shown in Table S4. There were no significant changes in the selectivity of the products with the change of the support.

Extension to C2 activation

The substrate scope of the reaction was investigated with higher hydrocarbons (C2) as shown in Table 2. Both methanol and ethanol were observed in the presence of ethane and the collective yield (8.1%) was more than the methanol yield (6.5%) in the methane reaction.

Table 2 The substrate scope of sub-supercritical acetonitrile and boron nitride catalyzed methane activation on C1–C2 hydrocarbon.

Isotopic label experiment

In order to eliminate the assumption of methanol formation from solvent acetonitrile, 13C labeled methane was used for the experiment while keeping other parameters constant (400 mg h-BN, 3 mL acetonitrile, 7 mmol of O2, 118 mmol of 13CH4 (99% pure), and 163 mmol He. All gases were cold fed to a total of ~ 1570 psi at − 30 °C. The reactor was heated at a 2.5 °C/min ramp rate to 275 °C. The heater cut off was set at 275 °C (no dwell time). The stirring speed was set at 60 rpm). After cooling down the reactor the filtered solution was injected to GC–MS to analyze the formed products.

Pre- and post-catalytic studies

According to the Auger electron spectroscopic (AES) data a slight decrease in the intensity of the oxygen KLL signal in the post-reaction h-BN catalyst was seen in comparison to the pre-reaction h-BN (Fig. S3). 11B solid state NMR (SS-NMR) data also indicated the decrease in the B(OH)xO3-x bond intensity at 15.5 ppm (Fig. 6a, Table 3) upon comparison between pre- and post-reaction h-BN33. Furthermore, post-reaction h-BN 15N SS-NMR showed a downshift in comparison to the pre-reaction h-BN (Fig. 6b).

Figure 6
figure 6

(a) MAS 11B SS-NMR spectra, (b) 15N SS-NMR spectra of pre- and post-reaction h-BN. Reaction conditions used; 400 mg h-BN, 118 mmol CH4, 7 mmol O2, 163 mmol He, 57 mmol acetonitrile, 275 °C, no dwell time, and 60 rpm stirring.

Table 3 Summary of experimentally measured and literature 11B SS-NMR parameters.

The X-ray photoelectron spectroscopy (XPS) analysis showed an increase in O–H%, decrease in O–B%, increase in N–B%, increase in N–H%, increase in B–N%, and decrease in B–O% in post-reaction h-BN compared to pre-reaction h-BN37,38,39,40. The binding energies of both B and N of post-reaction h-BN shifted to lower binding energies compared to pre-reaction h-BN (Table S5). The crystallinity of the h-BN was increased after the reaction when compared to pre-reaction h-BN (Fig. 7).

Figure 7
figure 7

X-ray diffraction analysis of pre- and post-reaction h-BN. Reaction conditions used; 400 mg h-BN, 118 mmol CH4, 7 mmol O2, 163 mmol He, 57 mmol acetonitrile, 275 °C, no dwell time, and 60 rpm stirring.

Discussion

Control of the available amount of oxygen is critical since oxygen is responsible for both methane conversion and product overoxidation41. Sato et al. used a lower O2/CH4 molar ratio (0.03) for methane conversion in supercritical water42. The methane to oxygen ratio study showed that relatively higher oxygen amounts (22 mmol) lead to lower methanol yields (Fig. 1) probably due to product overoxidation. As the oxygen amount decreased (22 mmol to 7 mmol) the available oxygen molecules that participate in both overoxidation and conversion reactions may have been diminished which would result in a tradeoff in yield. Increase in the yield even upon decreasing the oxygen content (constant methane) suggests that at lower oxygen partial pressures the methane activation reaction surpasses the overoxidation3. Another explanation can be introduced in terms of the supercritical solvent clustering effect explained elsewhere21. Methane can be converted to methanol inside the acetonitrile cluster by activated oxygen, and methanol can be subsequently released from the cluster into an oxygen-rich bulk solution where the oxidation takes place. As the oxygen content decreased the spectating oxygen in the bulk can be decreased which results in improved yield. At even lower oxygen content (3 mmol) oxygen could be acting as a limiting reactant inside the cluster resulting in slightly lower yield (4.7%) compared to 7 mmol reactions (5.2%). Even though evidence to isolate the exact mechanism has not been established, both these explanations stem from the overoxidation hypothesis.

Experiments conducted at three temperatures; below (250 °C), just above (275 °C), and above (300 °C) critical temperatures further corroborate the overoxidation phenomena. When the solvent temperature stays below the critical temperature, the clustering effect can be limited which would result in lower to no methanol yield (0.3%) due to overoxidation. Higher carbon dioxide selectivity at 250 °C (50%) compared to 275 °C eliminates the possibility of lack of enough energy for activation. Just above supercritical conditions, 275 °C, CO2 selectivity decreased to 15% suggesting product protection by cluster formation at supercritical conditions. Even though more yield through cluster formation is possible at 300 °C, higher temperatures may have contributed to the total combustion of methane to carbon dioxide (80% CO2 selectivity).

The static dielectric constant and density of acetonitrile depend on the temperature and pressure (reduced density) of the system43,44. As temperature increases, density and dielectric constant decrease whereas pressure has a completely opposite effect. At the critical point (272.35 °C, 703.43 psi) the density of acetonitrile was reported as 0.225 g/mL whereas the density of methane, methanol, benzene, carbon dioxide, and nitrogen are 0.162, 0.270, 0.210, 0.225, 0.313 g/mL respectively44. At critical pressure, the dielectric constant of acetonitrile is 40.3 (25 °C) and at critical temperature extrapolated values go down to 0.66 (at 1 bar)45. Due to the above reasons, acetonitrile is expected to behave as an apolar gaseous solvent with high apolar compound solubility (103 to 108) which can facilitate methane solubility46. Organic solvents in high-pressure or supercritical pressure can arrange into high density localized microreactor pockets due to high compressibility47,48. The size of these clusters can be altered based on the pressure of the system48. Oxygen and methane can be activated inside the apolar clusters via strong solvent-gas interactions and product molecules can be protected against overoxidation. We have probed high pressure differential scanning calorimetry (DSC) of acetonitrile and O2 under the same reaction conditions as for methane partial oxidation and have seen no oxidation of acetonitrile at short residence times. We have also probed the potential of clustering phenomena by using diffusivity measurements via high pressure NMR. These clustering phenomena seem to be dynamic and shorter than the NMR timescale. NMR chemical shift measurements show that the acetonitrile remains unchanged under the reaction conditions in the presence of O2.

Strong interactions between oxygen/methane and acetonitrile clusters are believed to activate the gaseous reactant molecules. As the solvent to oxygen ratio increased, the number of available solvent molecules to make strong interactions with solutes (methane, oxygen), hence clustering, would have been increased. Low product yield (0.2%) at low acetonitrile (10 mmol) concentrations could be attributed to insufficient cluster formation. The results infer that in order to form an adequate number of clusters, the solvent to oxygen ratio should exceed a critical value (in this case 5.2). The molar fraction of solvent (acetonitrile) in a mixture determines the critical temperature and pressure. As the acetonitrile molar fraction decreases, the critical temperature also decreases while the critical pressure can show a positively skewed curve21. If similar behavior is assumed, the critical condition (T, P) should be decreased compared to pure acetonitrile within the operating acetonitrile molar fraction regime of this study (0.03 to 0.17).

Use of acetonitrile as the subcritical solvent was justified by studying conventional supercritical systems such as water and carbon dioxide. The results showed that supercritical acetonitrile derivatives deliver higher methanol yields compared to conventional supercritical systems. All the reactions were performed at 275 °C (despite the critical point of water at 375 °C) due to significant methanol overoxidation at temperatures above 275 °C. The hydrogen-bonded cluster network of water decreases at supercritical temperature transforming into a tetrahedral packing structure49. The energetically most favorable five-membered cluster can be formed by hydrogen bonding between H and N of different acetonitrile molecules50. The hydrogen bonding strength, a common factor in both systems, can be disrupted by another hydrogen bonding additive/product. Electronegative -fluoro and -chloro derivatives of acetonitrile that have very similar boiling points (e.g., CH3CN 82 °C, FCH2CN 79–80 °C, Cl3CCN 83–84 °C) potentially impact the cluster properties and O2 solvation in a way that leads to lower methanol yields. Apolar carbon dioxide and benzene, on the other hand, can only participate in London dispersion forces and resulted in lower methanol yield (0.5% and 0.04% respectively). The critical points of benzene (289 °C) and acetonitrile (272 °C) are similar.

The 70% and 260% (from 4.6% yield, Fig. 3, Supplementary Table S3) increase in methanol yield (compared to no h-BN) with 1.15: 1 and 2.30: 1 h-BN: oxygen molar ratio of h-BN respectively, can be attributed to the hydrogen abstraction ability of h-BN and supercritical acetonitrile synergetic effects. Lower yield (0.4%) with carbon nitride (Table S2), a 2D structure similar to h-BN (Fig. S3), suggests a structure independent methane conversion pathway. Lower yields with other nitrides such as TiN, and InN, suggest unique chemistry of h-BN. The 50% increase (Table S3) in the methanol yield under stirring compared to no stirring typically suggests mass transfer limitations in the supercritical acetonitrile or h-BN system29. All reactions were performed at the maximum (60 rpm) stirring speed of the propeller to mitigate mass transfer limitations. This experiment demonstrated that even in the absence of acetonitrile, boron nitride itself could activate methane to methanol (3% yield) conversion under supercritical conditions. Addition of the yields only with BN (3%) and only with acetonitrile (4.6%) almost tally with the BN and acetonitrile yield (7.8%). The decrease in the methanol yield after 2.30: 1 h-BN: oxygen molar ratio of h-BN loading (Fig. 3) suggests mass transfer limitations in the system. The optimal solvent: oxygen molar ratio of 8.2 with or without h-BN further suggest a synergetic effect of supercritical acetonitrile and h-BN systems.

The doubt of methanol formation from the solvent acetonitrile rather than methane was cleared using 13C isotope labeled methane for the reaction while keeping other parameters unchanged. Upon analyzing the products using GC–MS, mass fragments for methanol peak m/z = 32 and 33 were shown as the highest abundant species respectively for 13CH3O and 13CH3OH fragments (Fig. S2).

The decrease in the intensity of the oxygen KLL peak of the post-reaction catalyst in comparison to the pre-reaction catalyst (Fig. S3) in the AES spectra could be due to oxygen terminated B–O bond dissociation during the methane oxidation reaction. Also, the decrease in the 15.7 ppm peak representing B–O in MAS 11B SS-NMR (Fig. 6a) upon comparison between pre- and post-reaction h-BN further confirm the observations shown from AES data. Furthermore, post-h-BN 15N-SSNMR showed a downshift in comparison to the pre-h-BN (Fig. 6b). This could be mainly due to the proton abstraction by N atoms in h-BN during the reaction. The observation of the decrease in the B–O (break in B–O–O–N bridge) after the reaction (Fig. 8) in XPS data agrees quite well with the AES and SS-NMR data. These data corresponded to a previously reported oxidative dehydrogenation (ODH) reaction mechanism (active site; an oxygen terminated armchair edge of BN bridge, B–O–O–N) of C2–C4 alkanes, to some extent30. However, methane conversion could not be explained with the ODH pathway. Methane to ethene oxidative coupling reaction mechanism on h-BN (active site; B–OH) suggested by Wang et al.29 could not explain the observations noted above, indicating that the active site for the reaction could be the terminal B–O–B bridge of h-BN. Based on the above facts, CH bond activation could occur on bridging oxygen sites to generate chemisorbed methoxy and hydroxyl groups (similar to the first step of ODH) which then desorbed to generate methanol. It is remarkable how the C2–C4 alkane ODH catalyst (h-BN)51,52,53 is also active for methane and ethane oxygenation reactions under supercritical conditions.

Figure 8
figure 8

X-ray photoelectron spectroscopic (XPS) analysis of pre and post-reaction for h-BN obtained with Physical Electronics Quantum 200 scanning ESCA microprobe with Al Kα radiation (29.35 eV pass energy, charge compensated with adventitious carbon 284.8 eV).

In most heterogeneous supercritical and subcritical thermal catalysis literature reports, methanol yield (methane-based) stays around 1%23,54 which showcases the uniqueness of the current study. The maximum carbon-based yield of 2% and oxygen-based yield of 17% under subcritical thermal catalysis have not been reported to date.

Conclusions

In summary, a metal-free thermal catalytic partial oxidation of methane to methanol was developed using h-BN under near supercritical acetonitrile to lead to a yield of 17% (oxygen-based) of methanol. Furthermore, an extension of this method to ethane (C2) leads to 3.6% and 4.5% (oxygen-based) yields of methanol and ethanol respectively.

Abbreviations

SFE:

Solvation free energy

MTL:

Mass transfer limitations

SC:

Supercritical

NSC:

Near supercritical

h-BN:

Hexagonal boron nitride

GC:

Gas chromatography

NMR:

Nuclear magnetic resonance

DSC:

Differential scanning calorimetry

ODH:

Oxidative dehydrogenation

MAS:

Magic angle spinning

References

  1. Kuld, S. et al. Quantifying the promotion of Cu catalysts by ZnO for methanol synthesis. Science 352, 969–974 (2016).

    ADS  CAS  PubMed  Article  Google Scholar 

  2. Sushkevich, V. L., Palagin, D., Ranocchiari, M. & Van Bokhoven, J. A. Selective anaerobic oxidation of methane enables direct synthesis of methanol. Science 356, 523–527 (2017).

    ADS  CAS  PubMed  Article  Google Scholar 

  3. Ravi, M., Ranocchiari, M. & van Bokhoven, J. A. The direct catalytic oxidation of methane to methanol—A critical assessment. Angew. Chem. Int. Ed. 56, 16464–16483 (2017).

    CAS  Article  Google Scholar 

  4. Narsimhan, K., Iyoki, K., Dinh, K. & Román-Leshkov, Y. Catalytic oxidation of methane into methanol over copper-exchanged zeolites with oxygen at low temperature. ACS Cent. Sci. 2, 424–429 (2016).

    CAS  PubMed  PubMed Central  Article  Google Scholar 

  5. Dinh, K. T. et al. Continuous partial oxidation of methane to methanol catalyzed by diffusion-paired copper dimers in copper-exchanged zeolites. J. Am. Chem. Soc. 141, 11641–11650 (2019).

    CAS  PubMed  Article  Google Scholar 

  6. Jin, Z. et al. Hydrophobic zeolite modification for in situ peroxide formation in methane oxidation to methanol. Science 367, 193–197 (2020).

    ADS  CAS  PubMed  Article  Google Scholar 

  7. Williams, C. et al. Selective oxidation of methane to methanol using supported AuPd catalysts prepared by stabilizer-free sol-immobilization. ACS Catal. 8, 2567–2576 (2018).

    CAS  Article  Google Scholar 

  8. Shi, C. et al. Direct conversion of methane to methanol and formaldehyde over a double-layered catalyst bed in the presence of steam. Chem. Commun. https://doi.org/10.1039/cc9960000663 (1996).

    Article  Google Scholar 

  9. Almond, M. J. et al. Carbonyl sulfide (OCS) as a sulfur-containing precursor in MOCVD: A study of mixtures of Me2Cd and OCS in the gas and solid phases and their use in MOCVD. J. Mater. Chem. 6, 1639 (1996).

    CAS  Article  Google Scholar 

  10. Kondratenko, E. V. et al. Catalysis Science & technology perspective methane conversion into different hydrocarbons or oxygenates: Current status and future perspectives in catalyst development and reactor operation. Catal. Sci. Technol. 7, 19–33 (2014).

    Google Scholar 

  11. Latimer, A. A., Kakekhani, A., Kulkarni, A. R. & Nørskov, J. K. Direct methane to methanol: The selectivity-conversion limit and design strategies. ACS Catal. 8, 6894–6907 (2018).

    CAS  Article  Google Scholar 

  12. Brown, M. J. & Parkyns, N. D. Progress in the partial oxidation of methane to methanol and formaldehyde. Catal. Today 8, 305–335 (1991).

    CAS  Article  Google Scholar 

  13. Feng, N. et al. Efficient and selective photocatalytic CH4 conversion to CH3 OH with O2 by controlling overoxidation on TiO2. Nat. Commun. https://doi.org/10.1038/s41467-021-24912-0 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  14. Trinh, Q. T., Banerjee, A., Yang, Y. & Mushrif, S. H. Sub-surface boron-doped copper for methane activation and coupling: First-principles investigation of the structure, activity, and selectivity of the catalyst. J. Phys. Chem. C 121, 1099–1112 (2017).

    CAS  Article  Google Scholar 

  15. Collins, N. A., Debenedetti, P. G. & Sundaresan, S. Disproportionation of toluene over ZSM–5 under near-critical conditions. AIChE J. 34, 1211–1214 (1988).

    CAS  Article  Google Scholar 

  16. Theyssen, N., Hou, Z. & Leitner, W. Selective oxidation of alkanes with molecular oxygen and acetaldehyde in compressed (supercritical) carbon dioxide as reaction medium. Chem. A Eur. J. 12, 3401–3409 (2006).

    CAS  Article  Google Scholar 

  17. Brock, E. E., Oshima, Y., Savage, P. E. & Barker, J. R. Kinetics and mechanism of methanol oxidation in supercritical water. J. Phys. Chem. 100, 15834–15842 (1996).

    CAS  Article  Google Scholar 

  18. Savage, P. E., Li, R. & Santini, J. T. Methane to methanol in supercritical water. J. Supercrit. Fluids 7, 135–144 (1994).

    CAS  Article  Google Scholar 

  19. Savage, P. E., Rovira, J., Stylski, N. & Martino, C. J. Oxidation kinetics for methane/methanol mixtures in supercritical water. J. Supercrit. Fluids 17, 155–170 (2000).

    CAS  Article  Google Scholar 

  20. Savage, P. E. Organic chemical reactions in supercritical water. Chem. Rev. 99, 603–621 (1999).

    CAS  PubMed  Article  Google Scholar 

  21. Ferrieri, R. A., Garcia, I., Fowler, J. S. & Wolf, A. P. Investigations of acetonitrile solvent cluster formation in supercritical carbon dioxide, and its impact on microscale syntheses of carbon-11-labeled radiotracers for PET. Nucl. Med. Biol. 26, 443–454 (1999).

    CAS  PubMed  Article  Google Scholar 

  22. Jessop, P. G. & Subramaniam, B. Gas-expanded liquids. Chem. Rev. 107, 2666–2694 (2007).

    CAS  PubMed  Article  Google Scholar 

  23. Lee, J. H. & Foster, N. R. Direct partial oxidation of methane to methanol in supercritical water. J. Supercrit. Fluids 9, 99–105 (1996).

    CAS  Article  Google Scholar 

  24. Webley, P. A. & Tester, J. W. Fundamental kinetics of methane oxidation in supercritical water. Energy Fuels 5, 411–419 (2002).

    Article  Google Scholar 

  25. Dixon, C. N. & Abraham, M. A. Conversion of methane to methanol by catalytic supercritical water oxidation. J. Supercrit. Fluids 5, 269–273 (1992).

    CAS  Article  Google Scholar 

  26. Zhang, X. et al. Methanol conversion on borocarbonitride catalysts: Identification and quantification of active sites. Sci. Adv. 6, 5778–5802 (2020).

    ADS  Article  CAS  Google Scholar 

  27. Wang, G., Zhang, X., Yan, Y., Huang, X. & Xie, Z. New insight into structural transformations of borocarbonitride in oxidative dehydrogenation of propane. Appl. Catal. A Gen. 628, 118402 (2021).

    CAS  Article  Google Scholar 

  28. Li, S., Zhang, X., Huang, X., Wu, S. & Xie, Z. Identification of active sites of B/N co-doped nanocarbons in selective oxidation of benzyl alcohol. J. Colloid Interface Sci. 608, 2801–2808 (2022).

    ADS  CAS  PubMed  Article  Google Scholar 

  29. Wang, Y. et al. Methane activation over a boron nitride catalyst driven by: In situ formed molecular water. Catal. Sci. Technol. 8, 2051–2055 (2018).

    CAS  Article  Google Scholar 

  30. Grant, J. T. et al. Selective oxidative dehydrogenation of propane to propene using boron nitride catalysts. Science 354, 1570–1573 (2016).

    ADS  CAS  PubMed  Article  Google Scholar 

  31. Venegas, J. M. et al. Selective oxidation of n-butane and isobutane catalyzed by boron nitride. ChemCatChem 9, 2118–2127 (2017).

    CAS  Article  Google Scholar 

  32. Tian, J. et al. Direct conversion of methane to formaldehyde and CO on B2 O3 catalysts. Nat. Commun. https://doi.org/10.1038/s41467-020-19517-y (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  33. Love, A. M. et al. Probing the transformation of boron nitride catalysts under oxidative dehydrogenation conditions. J. Am. Chem. Soc. 141, 182 (2019).

    CAS  PubMed  Article  Google Scholar 

  34. Turner, G. L., Smith, K. A., Kirkpatrick, R. J. & Oldfield, E. Boron-11 nuclear magnetic resonance spectroscopic study of borate and borosilicate minerals and a borosilicate glass. J. Magn. Reson. 67, 544–550 (1986).

    ADS  CAS  Google Scholar 

  35. Kroeker, S. & Stebbins, J. F. Three-coordinated boron-11 chemical shifts in borates. Inorg. Chem. 40, 6239–6246 (2001).

    CAS  PubMed  Article  Google Scholar 

  36. Gervais, C. et al. 11B and 15N solid state NMR investigation of a boron nitride preceramic polymer prepared by ammonolysis of borazine. J. Eur. Ceram. Soc. 25, 129–135 (2005).

    CAS  Article  Google Scholar 

  37. Huang, C., Liu, Q., Fan, W. & Qiu, X. Boron nitride encapsulated copper nanoparticles: A facile one-step synthesis and their effect on thermal decomposition of ammonium perchlorate. Sci. Rep. 5, 16736 (2015).

    ADS  CAS  PubMed  PubMed Central  Article  Google Scholar 

  38. Ci, L. et al. Atomic layers of hybridized boron nitride and graphene domains. Nat. Mater. 9, 430. https://doi.org/10.1038/NMAT2711 (2010).

    ADS  CAS  Article  PubMed  Google Scholar 

  39. Huang, C., Ye, W., Liu, Q. & Qiu, X. Dispersed Cu2O octahedrons on h-BN nanosheets for p-nitrophenol reduction. ACS Appl. Mater. Interfaces 6, 14469–14476 (2014).

    CAS  PubMed  Article  Google Scholar 

  40. Pilli, A. et al. In situ XPS study of low temperature atomic layer deposition of B2 O3 films on Si using BCl3 and H2O precursors articles you may be interested in in situ XPS study of low temperature atomic layer deposition of B2 O3 films on Si using BCl3 and H2O precursors. J. Vac. Sci. Technol. A 36, 61503 (2018).

    Article  CAS  Google Scholar 

  41. Gesser, H. D. & Prakash, C. B. Chemical reviews the direct conversion of methane to methanol by controlled oxidation. Chem. Rev. 85, 235 (1985).

    CAS  Article  Google Scholar 

  42. Sato, T., Watanabe, M., Smith, R. L., Adschiri, T. & Arai, K. Analysis of the density effect on partial oxidation of methane in supercritical water. J. Supercrit. Fluids 28, 69–77 (2004).

    CAS  Article  Google Scholar 

  43. Gagliardi, L. G., Castells, C. B., Ràfols, C., Rosés, M. & Bosch, E. Static dielectric constants of acetonitrile/water mixtures at different temperatures and Debye-Hückel A and a 0 B parameters for activity coefficients. J. Chem. Eng. Data 52, 1103–1107 (2007).

    CAS  Article  Google Scholar 

  44. Hong Wei Xiang. The Corresponding-States Principle and Its Practice (Elsevier, 2005).

    Google Scholar 

  45. Srinivasan, K. R. & Kay, R. L. The pressure dependence of the dielectric constant and density of acetonitrile at three temperatures. J. Solut. Chem. 6, 357–367 (1977).

    CAS  Article  Google Scholar 

  46. Brennecke, J. F. & Eckert, C. A. Phase equilibria for supercritical fluid process design. AIChE J. 35, 1409–1427 (1989).

    CAS  Article  Google Scholar 

  47. Kim, S. & Johnston, K. P. Clustering in supercritical fluid mixtures. AIChE J. 33, 1603–1611 (1987).

    CAS  Article  Google Scholar 

  48. Ikushima, Y., Saito, N. & Arai, M. Supercritical carbon dioxide as reaction medium: Examination of its solvent effects in the near-critical region. J. Phys. Chem. 96, 2293–2297 (1992).

    CAS  Article  Google Scholar 

  49. Petrenko, V. E., Gurina, D. L. & Antipova, M. L. Structure of supercritical water: The concept of critical isotherm as a percolation threshold. Russ. J. Phys. Chem. B 6, 899–906 (2012).

    CAS  Article  Google Scholar 

  50. Gribov, L. A., Novakov, I. A., Pavlyuchko, A. I., Korolkov, V. V. & Orlinson, B. S. Spectroscopic calculation of CH bond dissociation energies for aliphatic nitriles. J. Struct. Chem. 45, 771–777 (2004).

    CAS  Article  Google Scholar 

  51. Shi, L. et al. Progress in selective oxidative dehydrogenation of light alkanes to olefins promoted by boron nitride catalysts. Chem. Commun. 54, 10936–10946 (2018).

    CAS  Article  Google Scholar 

  52. Venegas, J. M. et al. Why boron nitride is such a selective catalyst for the oxidative dehydrogenation of propane. Angew. Chem. Int. Ed. 59, 16527–16535 (2020).

    CAS  Article  Google Scholar 

  53. Grant, J. T. et al. Boron and boron-containing catalysts for the oxidative dehydrogenation of propane. ChemCatChem 9, 3623–3626 (2017).

    CAS  Article  Google Scholar 

  54. Zakaria, Z. & Kamarudin, S. K. Direct conversion technologies of methane to methanol: An overview. Renew. Sustain. Energy Rev. 65, 250–261 (2016).

    CAS  Article  Google Scholar 

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Acknowledgements

Authors would like to appreciate Dr. Bill Willis, the University of Connecticut for acquiring X-ray photoelectron spectroscopic data.

Funding

This work was supported by ExxonMobil. Partial support of the U. S. Department of Energy, Office of Basic Energy Sciences, Division of Chemical, Biological and Geological Sciences under Grant DE-FG02-86ER13622 is highly appreciated.

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Conceptualization, S.S. and P.N.; Methodology, K.K.T., M.E., I.P.; Investigation, K.K.T., M.E., I.P.; Writing, K.K.T., I.P.; Review & Editing, S.S. and P.N.; Funding Acquisition, P.N.; Resources, S.S. and P.N.; Supervision, S.S. and P.N. All authors reviewed the manuscript.

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Kapuge, T.K., Moharreri, E., Perera, I. et al. Partial oxidation of methane to methanol on boron nitride at near critical acetonitrile. Sci Rep 12, 8577 (2022). https://doi.org/10.1038/s41598-022-12639-x

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