Table 2 Doxycycline treatment patterns by diagnostic and age groups among outpatients diagnosed with rickettsial diseases in a large, commercially insured population — United States, 2005–2017.

From: Patient characteristics, treatment patterns, and outcomes of Rickettsial diseases among a commercially insured population in the United States, 2005–2017

Doxycycline prescription rates  
Outpatients with doxycycline by diagnostic groupa
All 7,878 (53.1)
Spotted fever rickettsioses (n = 7,517) 4,595 (61.1)
Ehrlichiosis (n = 4,571) 2,476 (54.2)
Typhus (n = 1,362) 328 (24.1)
Other rickettsial diseases (n = 1,193) 415 (34.8)
 > 1 diagnostic group (n = 187) 64 (34.2)
Outpatients with doxycycline by age groupa  
 < 8 yrs. (n = 699) 167 (23.9)
8–17 yrs. (n = 1,475) 704 (47.7)
≥18 yrs. (n = 12,656) 7,007 (55.4)
Time from index date to prescription (days)  
Median (IQR) 0 (-9–0)
n, % of patients with prescription within ± 14 days of index date 6,520 (82.8)
n, % of patients with prescription within ± 7 days of index date 5,427 (68.9)
Characteristics of first doxycycline prescription by age group
 < 8 yrs. (n = 167)  
Time from index date to prescription (days)  
Median (IQR) 0 (-1–0)
n, % of patients with prescription within ± 14 days of index date 157 (94.0)
Days’ supply, median days (IQR) 10 (7–10)
ROA  
IV 0 (0)
Oral 167 (100)
Dosing and treatment patterns  
100 mg PO 10 days 6 (3.6)
Suspension PO 10 days 65 (38.9)
8–17 yrs. (n = 704)  
Time from index date to prescription (days)  
Median (IQR) 0 (-3–0)
n, % of patients with prescription within ± 14 days of index date 627 (89.1)
Days’ supply, median days (IQR) 10 (10–14)
ROA  
IV 1 (0.1)
Oral 703 (99.9)
Dosing and treatment patterns  
100 mg PO 10 days 442 (62.3)
≥18 yrs. (n = 7,007)  
Time from index date to prescription (days)  
Median (IQR)  -1 (-10–0)
n, % of patients with prescription within ± 14 days of index date 5,736 (81.9)
Days’ supply, median days (IQR) 14 (10–15)
ROA  
IV 3 (0.1)
Oral 7,004 (99.9)
Dosing and treatment patterns  
100 mg PO 10 days 6,028 (86.0)
  1. Data are presented as No. (%) unless otherwise indicated.
  2. ROA route of administration, IV intravenous, mg milligrams, PO by mouth.
  3. Recommended dosing is 100 mg twice daily for adults or children ≥ 45 kg, and 2.2 mg/kg/dose twice daily for children < 45 kg. Duration of treatment is 5–7 days or at least 3 days after fever subsides or patient shows signs of clinical recovery.
  4. aPercentages reflect the proportion of patients within that diagnostic or age category who received the recommended dosing and duration of doxycycline. Remaining patients either received a non-recommended dosing/duration of doxycycline or no prescription was identified in the database.