Figure 6 | Scientific Reports

Figure 6

From: Adipogenesis in triple-negative breast cancer is associated with unfavorable tumor immune microenvironment and with worse survival

Figure 6

Association of adipogenesis score with neoadjuvant chemotherapy (NAC) response and expression of immune checkpoint molecules in TNBC. (A) Bar plots of pathological compete response (pCR) rate after NAC between low (blue) and high (red) adipogenesis score in ER+/HER2− and TNBC in the GSE25066 and GSE20194 cohorts. The numbers under the chart are pCR case number/number of patients in that group that makes the pCR rate. Error bar showed Standard Error. P-value was calculated by Fisher’s test. (B) Boxplots of comparison between low- and high-adipogenesis score with mRNA expression of PD-1/PDCD1, PD-L1/CD274, PD-L2/PDCD1LG2, and CTLA4 genes, and (C) immune checkpoint molecules index in TNBC in the GSE96058 and TCGA cohorts. P-value was calculated using Mann–Whitney U test. Median value was used as the cut-off to divide into low- and high- adipogenesis score groups within each cohort. PD-1 programmed cell death 1; PD-L1 programmed cell death 1 ligand 1, PD-L2 programmed cell death 1 ligand 2, CTLA4 cytotoxic T-lymphocyte-associated protein 4.

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