Figure 5 | Scientific Reports

Figure 5

From: Adipogenesis in triple-negative breast cancer is associated with unfavorable tumor immune microenvironment and with worse survival

Figure 5

Homologous recombination deficiency (HRD), mutation load, fractions of tumor infiltrating immune cells and cytolytic activity between low and high adipogenesis triple negative breast cancer (TNBC) in the GSE96058 and TCGA cohorts. (A) Boxplots of HRD, altered fraction, silent and non-silent mutation, single nucleotide variation (SNV) and indel neoantigens by the adipogenesis in TNBC. (B) The comparison of immune cells; CD8+ T cells, CD4+ memory T cells, T helper type 1 cells (Th1) and Th2, regulatory T cells (Tregs), M1 and M2 macrophage, and (C) cytolytic activity score (CYT). Median value was used as the cut-off to divide into low and high adipogenesis score groups within each cohort. P-value was calculated using Mann–Whitney U test.

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