Figure 2 | Scientific Reports

Figure 2

From: A bispecific antibody agonist of the IL-2 heterodimeric receptor preferentially promotes in vivo expansion of CD8 and NK cells

Figure 2

IL-2Rβγ bispecific UniAbs induce proliferation and STAT5 phosphorylation in PBMCs. (A to F) pSTAT5 dose curves for human CD8+ T-cells (A), CD56hi NK-cells (B), CD4+ Conventional T-cells (C), CD4+ Regulatory T-cells (D), cynomolgus CD8+ T-cells (E), and total CD4+ T-cells (F). pSTAT5 levels were determined by flow cytometry and were reported as a percentage of the indicated cell type. (G to J) Ki67 dose curves for human CD8+ T-cells (G), CD56hi NK-cells (H), CD4+ Conventional T-cells (I), CD4+ Regulatory T-cells (J). Ki67 levels were determined by flow cytometry and were reported as a percentage of the indicated cell type. CD4+ Conventional T-cells are defined here as CD3+CD4+Foxp3-. CD4+ Regulatory T-cells are defined here are CD3+CD4+CD25+Foxp3+.

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