Table 4 Comparative analysis between clinical variables and ATR-FTIR spectral data from plasma samples.

From: Distinguishing active from quiescent disease in ANCA-associated vasculitis using attenuated total reflection Fourier-transform infrared spectroscopy

Active disease Sensitivity of clinical variable Specificity of clinical variable Coefficients of determination (R2)
Age 0.01
Gender 0.75 0.77 0.29
BVAS 0.19
Organ involvement:    
Constitutional signs or symptoms 0.60 0.60 0.00
Mucous Membrane/Ophthalmic 0.58 0.50 0.12
Cutaneous 0.83 1.00 0.02
ENT 0.39 0.67 0.14
Respiratory 0.58 0.50 0.02
Cardiovascular 1.00 1.00 0.00
Renal 1.00 0.94 0.52
Neurological 0.50 0.20 0.04
ANCA Positivity 0.67 0.75 0.06
ANCA Serotype    
MPO 0.44 0.50 0.00
PR3 0.67 0.38 0.01
Negative 0.75 0.71 0.02
ANCA titre 0.12
Serum creatinine (μmol/L) 0.27
eGFR(mls/min/1.73m2) 0.45
Haemoglobin 0.51
White cell count 0.51
Lymphocyte count 0.24
Neutrophil count 0.52
Platelet count 0.08
CRP 0.18
ESR 0.29
Serum albumin 0.86
Total protein 0.65
  1. ENT ear nose and throat, ANCA anti-neutrophil cytoplasmic autoantibody, MPO myeloperoxidase, PR3 proteinase-3, BVAS Birmingham vasculitis activity score, eGFR estimated glomerular filtration rate, ESR erythrocyte sedimentary rate, CRP C-reactive protein.