Table 2 Extracellular free water, blood markers and cognitive data at baseline and follow-up visits.

From: A longitudinal analysis of brain extracellular free water in HIV infected individuals

Parameter BSL W12 Y1 Y2
HIV+  HIV− HIV+  HIV− HIV+  HIV− HIV+  HIV−
Participants (n) 44 52 38 0 29 46 19 41
FW index (%)
GM 17.42 ± 0.44 13.76 ± 0.64 14.41 ± 0.91 17.91 ± 0.48 17.72 ± 0.41 18.08 ± 0.59 18.03 ± 0.38
WM 4.82 ± 0.12 4.46 ± 0.12 4.44 ± 0.15 4.87 ± 0.15 4.98 ± 0.11 4.86 ± 0.21 4.99 ± 0.11
Blood markers
CD4+ 509.66 ± 41.24 587.00 ± 47.20 703.76 ± 58.14 787.78 ± 67.95
VL (× 102) 782.36 ± 205.85 4.31 ± 3.96 12.39 ± 12.23 0.22 ± 0.08
NfL 14.65 ± 3.37 7.32 ± 0.56* 10.04 ± 1.67 10.37 ± 2.98 10.55 ± 2.62 7.51 ± 0.59+
Total cognitive score − 1.62 ± 0.56 0.21 ± 0.59 − 0.19 ± 0.63 − 0.42 ± 0.71 1.64 ± 0.75 − 0.46 ± 0.93 2.41 ± 0.78
  1. Values are Mean ± Standard Error; Units: Free Water, FW in %; Viral Load, VL in copies/mL; CD4 + T cell in count/mm3; Neurofilament Light Chain, NfL in pg/mL; grey matter, GM; white matter, WM; —indicates data are not available.
  2. *Indicates n = 15.
  3. +Indicates n = 10.