Table 3 Clinicopathological features selection using the univariable and multivariate Cox logistic regression model among the training group.

From: Development and validation for prognostic nomogram of epithelial ovarian cancer recurrence based on circulating tumor cells and epithelial–mesenchymal transition

Variables Univariate analysis Multivariate analysis
Hazard ratio 95% CI* p-value Hazard ratio 95% CI* p-value
Age (years) 1.131 1.028–1.954 0.045 1.089 0.922–1.317 0.058
BMI (kg/m2) 1.016 0.969–1.064 0.514
Tumor size (cm) 1.271 1.014–1.298 0.048 0.933 0.815–1.069 0.314
Menopausal status
 Pre/peri-menopause Reference Reference
 Post-menopause 1.153 1.037–1.209 0.047 3.498 0.196–6.374 0.394
Fertility history
 0–1 Reference
 ≥ 2 0.989 0.967–1.025 0.574
Pathological grade
 G1–2 Reference Reference
 G3 1.509 1.031–4.506 0.034 1.382 1.104–3.965 0.041
FIGO stage
 I–II Reference Reference
 III–IV 2.534 1.293–4.966 0.007 2.391 1.230–4.377 0.011
Lymph node metastasis
 Negative Reference Reference
 Positive 1.269 1.045–3.582 0.036 1.312 1.029–2.975 0.039
Ascites
 Negative Reference Reference
 Positive 1.123 1.042–1.301 0.017 1.215 1.067–1.806 0.026
CTC counts (n/5 mL) 1.241 1.108–1.384 0.009 1.187 1.098–1.752 0.012
M-CTC (n %) 1.147 1.051–1.288 0.006 1.098 1.047–1.320 0.009
E-CTC (n %) 0.983 0.857–2.694 0.148
Hybrids-CTC (n %) 1.058 0.894–1.753 0.365
Neutrophil (109/L) 1.015 0.992–1.038 0.207
Lymphocyte (109/L) 1.066 0.888–1.278 0.494
Platelet (109/L) 1.002 0.997–1.007 0.351
Albumin (g/L) 0.909 0.849–0.972 0.025 1.027 0.980–1.077 0.266
CA-125 (U/mL) 1.101 1.002–1.203 0.019 1.097 1.021–1.373 0.028
CA-199 (U/mL) 0.977 0.942–1.012 0.198
AFP (ng/mL) 1.001 0.963–1.040 0.958
CEA (ng/mL) 1.001 0.999–1.012 0.805
HE4 (pmol/L) 1.217 1.104–1.232 0.039 0.959 0.850–1.081 0.489
  1. BMI Body Mass Index, FIGO the International Federation of Gynecology and Obstetrics, CTC circulating tumor cell, M-CTC mesenchymal CTCs/ total CTCs percentage, E-CTC epithelial CTCs/ total CTCs percentage, Hybrids-CTC hybrids CTCs/ total CTCs percentage, CA-125 carbohydrate antigen-125, CA-199 carbohydrate antigen-199, CEA carcinoembryonic antigen, AFP alpha-fetoprotein, HE4 human epididymis protein 4.