Table 4 A comparison of the summary statistics for six SNPs in the current study that were reported as genome wide significant in the study by Clifford et al.

From: Genome-wide association study suggests that variation at the RCOR1 locus is associated with tinnitus in UK Biobank

Current study Clifford et al. Table 1
SNP CHR BP A1 A2 A1 freq INFO BETA SE P A1 freq INFO BETA SE P
rs143424888 1 103456996 C CACGTGATCT 0.508 0.973 − 0.006 0.001351 9.00E−06 0.510 0.973 − 0.023 0.004 8.50E−09
rs17249745 4 102547366 A G 0.968 0.897 − 0.018 0.003997 1.00E−05 0.967 0.897 − 0.072 0.012 1.30E−09
rs553448379 6 43288656 T TA 0.384 0.989 − 0.007 0.001378 4.60E−07 0.386 0.989 − 0.023 0.004 2.10E−08
rs11249981 8 10147398 C T 0.449 0.990 − 0.007 0.001346 1.20E−06 0.447 0.990 − 0.022 0.004 4.60E−08
rs72815660 10 106614698 A G 0.961 0.986 − 0.014 0.003467 4.10E−05 0.960 0.986 − 0.060 0.010 9.70E−09
rs11174489 12 62852271 G A 0.626 0.995 − 0.006 0.001384 1.10E−05 0.625 0.995 − 0.024 0.004 3.80E−09
  1. Bold denotes those SNPs that were replicated in the Clifford et al. study. Chr, chromosome; SNP, single nucleotide polymorphism; bp, base position; A1, allele A1; A2 allele A2; A1 freq, allele frequency of allele A1; Info, estimated imputation info score; beta, effect size from BOLT-LMM approximation to infinitesimal mixed model; se, standard error of the beta; p-value, non-infinitesimal mixed model association test p-value. NB. In Table 1 of Clifford et al. in the printed paper the effect sign is opposite for rs143424888, which appears to be an error; see their Supplementary eTable 5.