Locus Plots for rs4906228 association with tinnitus and hearing difficulty in UKBB. (A) Locus plot for lead SNP at genome-wide significance on Chr14, rs4906228 in genetic association analysis with frequency of tinnitus symptoms. Purple indicates lead independent SNP generated from GCTA-COJO conditional analysis. The colouring of remaining SNPs is based on the linkage disequilibrium (r2) with the leads. Where LD information is not available, SNPs are coloured grey. The genes within the region are annotated and the direction of transcription is indicated by arrows. (B) Same plot is shown for association of rs4906228 with self-reported hearing difficulty as described previously22.