Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Retraction Note: Amelioration of obsessive-compulsive disorder in three mouse models treated with one epigenetic drug: unraveling the underlying mechanism

The Original Article was published on 19 June 2019


Retraction of: Scientific Reports https://doi.org/10.1038/s41598-019-45325-6, publisher online 19 June 2019


The Editors have retracted this Article.


An investigation by the Research Integrity Office at Stony Brook University has concluded that:

  • some of the methodological and experimental descriptions in the paper show significant overlap with NIH grant application R01-NS104089, NARSAD grant application 23840, and a previously published article by Plotkin et al.1;

  • the Authors incorrectly reported results for Slitrk5 knockout mice. Due to problems with genotyping of these animals, the genetic identity of the individual animals was impossible to determine;

  • the Authors incorrectly reported results for Sapap3 knockout mice. The animals used in these experiments were Sapap3 conditional knock-in mice;

  • the experimental conditions in the behavioural tests were also incorrectly reported: the experimenters were not blind to experimental conditions as reported in the paper.

The Editors therefore no longer have confidence in the integrity of the data presented in this Article.


Catarina Cunha disagrees with the retraction. German Todorov, Karthikeyan Mayilvahanan and David Ashurov did not respond to the correspondence about this retraction.

References

  1. 1.

    Plotkin, J. L., Day, M. & Surmeier, D. J. Synaptically driven state transitions in distal dendrites of striatal spiny neurons. Nat. Neurosci. 14, 881–888 (2011).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Catarina Cunha.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Todorov, G., Mayilvahanan, K., Ashurov, D. et al. Retraction Note: Amelioration of obsessive-compulsive disorder in three mouse models treated with one epigenetic drug: unraveling the underlying mechanism. Sci Rep 11, 4869 (2021). https://doi.org/10.1038/s41598-021-84474-5

Download citation

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links