Table 2 Associations of HLA class II genes in individuals with a high response (HBsAb > 100 mIU/mL) to Heptavax-II and Bimmugen vaccines.

From: Importance of HBsAg recognition by HLA molecules as revealed by responsiveness to different hepatitis B vaccines

Haplotype/allele Heptavax-II Bimmugen Chi P OR 95% CI
Count % Count % Lower Upper
DRB1*01:01-DQB1*05:01 41 6.7 97 7.1 7.78E−01 0.95 0.65 1.38
DRB1*04:05-DQB1*04:01 105 17.2 166 12.1 2.22E03 1.51 1.16 1.97
DRB1*08:03-DQB1*06:01 47 7.7 139 10.1 8.73E−02 0.74 0.52 1.05
DRB1*09:01-DQB1*03:03 98 16.1 183 13.3 1.08E−01 1.24 0.95 1.62
DRB1*13:02-DQB1*06:04 17 2.8 93 6.8 3.40E04 0.39 0.23 0.67
DRB1*15:01-DQB1*06:02 42 6.9 116 8.5 2.34E−01 0.80 0.55 1.16
DRB1*15:02-DQB1*06:01 78 12.8 139 10.1 8.05E−02 1.30 0.97 1.75
DPB1*02:01 130 23.4 342 24.9 4.75E−01 0.92 0.73 1.16
DPB1*03:01 31 5.6 69 5.0 6.24E−01 1.12 0.72 1.72
DPB1*04:02 54 9.7 156 11.4 2.90E−01 0.84 0.60 1.16
DPB1*05:01 238 42.8 525 38.3 6.48E−02 1.21 0.99 1.48
DPB1*09:01 57 10.3 128 9.3 5.33E−01 1.11 0.80 1.54
  1. The estimated DRB1-DQB1 haplotype frequencies over 5.0% and DPB1 allele frequencies over 5.0% in individuals vaccinated with Bimmugen are shown. The total number of high-responders in Heptavax-II and Bimmugen was 278 and 686, respectively, for the DPB1 allele and 305 and 686, respectively, for the DRB1-DQB1 haplotype. Significance level (α) in HLA association analysis was determined by the sorting test, with P < 0.00368 for the DRB1-DQB1 haplotype and P < 0.00820 for the DPB1 allele. P values and odds ratios (OR) were calculated by Pearson’s chi-square test for presence vs. absence of each allele. P values and OR that were statistically significant after correction are indicated in bold.