Table 1 Associations of HLA class II alleles with a response to the Heptavax-II vaccine in a comparison between poor-responders (Group_0) and high-responders (Group_2).

From: Importance of HBsAg recognition by HLA molecules as revealed by responsiveness to different hepatitis B vaccines

Haplotype/allele Group_0 Group_2 Chi P OR 95% CI
Count % Count % Lower Upper
DRB1*01:01-DQB1*05:01 3 2.3 41 6.7 4.98E−02 0.32 0.10 1.06
DRB1*04:05-DQB1*04:01 40 30.3 105 17.2 5.84E04 2.09 1.36 3.20
DRB1*08:03-DQB1*06:01 5 3.8 47 7.7 1.10E−01 0.47 0.18 1.21
DRB1*09:01-DQB1*03:03 16 12.1 98 16.1 2.55E−01 0.72 0.41 1.27
DRB1*13:02-DQB1*06:04 6 4.5 17 2.8 2.91E−01 1.66 0.64 4.30
DRB1*15:01-DQB1*06:02 7 5.3 42 6.9 5.07E−01 0.76 0.33 1.73
DRB1*15:02-DQB1*06:01 14 10.6 78 12.8 4.91E−01 0.81 0.44 1.48
DPB1*02:01 20 15.9 130 23.4 6.62E−02 0.62 0.37 1.04
DPB1*03:01 6 4.8 31 5.6 7.16E−01 0.85 0.35 2.08
DPB1*04:02 6 4.8 54 9.7 7.65E−02 0.46 0.20 1.11
DPB1*05:01 76 60.3 238 42.8 3.70E04 2.03 1.37 3.01
DPB1*09:01 12 9.5 57 10.3 8.07E−01 0.92 0.48 1.77
  1. The estimated DRB1-DQB1 haplotype frequencies over 5.0% and DPB1 allele frequencies over 5.0% in high-responders (Group_2) are shown. The result of DRB1*13:02-DQB1*06:04 was added for discussion in the paper. The total numbers of poor-responders and high-responders were 63 and 278, respectively, for the DPB1 allele and 66 and 305, respectively, for the DRB1-DQB1 haplotype. Significance level (α) in HLA association analysis was determined by the sorting test, with P < 0.00293 for the DRB1-DQB1 haplotype and P < 0.00980 for the DPB1 allele. P values and odds ratios (OR) were calculated by Pearson’s chi-square test for presence vs. absence of each allele. P values and OR that were statistically significant after correction are indicated in bold.