Table 8 Regression analysis of factors associated with the RNFL thickness loss rate.

From: The effect of anxiety and depression on progression of glaucoma

RNFL thickness loss rate Univariate model Multivariate model
B β 95% CI P value B β 95% CI P value
Age, y  − 0.003  − 0.035  − 0.022 to 0.015 0.710     
Sex, male/female  − 0.029  − 0.013  − 0.426 to 0.369 0.546     
Hypertension, n (%)  − 0.288  − 0.089  − 0.878 to 0.302 0.336     
Diabetics, n (%)  − 0.018  − 0.003  − 1.109 to 1.073 0.998     
CCT, µm 0.001 0.057  − 0.146 to 0.105 0.747     
Axial length, mm  − 0.020  − 0.033  − 0.164 to 0.136 0.855     
PPA/Disc area (%) 0.102 0.034  − 0.454 to 0.658 0.717     
Tilt ratio 0.453 0.075  − 0.681 to 1.586 0.621     
Torsion ratio  − 0.015  − 0.137  − 0.035 to 0.005 0.150     
VF MD, dB 0.025 0.127  − 0.011 to 0.061 0.172     
VF PSD, dB  − 0.036  − 0.125  − 0.089 to 0.017 0.177     
VF MD rate, dB/year  − 0.008  − 0.027  − 0.090 to 0.074 0.847     
Mean IOP 0.003 0.011  − 0.050 to 0.056 0.907     
Peak IOP 0.047 0.116  − 0.004 to 0.098 0.072     
IOP fluctuation 0.096 0.262 0.031 to 0.161 0.015 0.092 0.251 0.030 to 0.154 0.004
Mean blood pressure 0.005 0.041  − 0.080 to 0.090 0.902     
Disc hemorrhage 0.075 0.015  − 0.859 to 1.008 0.874     
Heart rate variability 0.013 0.199 0.001 to 0.025 0.031 0.007 0.104  − 0.005 to 0.019 0.255
BAI score 0.068 0.315 0.030 to 0.105 0.001 0.058 0.272 0.020 to 0.097 0.003
BDI-II score 0.015 0.073  − 0.023 to 0.054 0.431     
  1. B, non-standardized coefficient; β, standardized coefficient; CI, confidence interval; CCT, central corneal thickness; PPA, peripapillary atrophy; VF, visual field; MD, mean deviation; PSD, pattern standard deviation; RNFL, retinal nerve fiber layer; IOP, intraocular pressure; BAI, Beck Anxiety Inventory; BDI-II, Beck Depression Inventory-II.
  2. Statistically significant values appear in boldface.