Factors associated with unplanned readmissions and costs following resection of brain metastases in the United States

The purpose of this study was to critically analyze the risk of unplanned readmission following resection of brain metastasis and to identify key risk factors to allow for early intervention strategies in high-risk patients. We analyzed data from the Nationwide Readmissions Database (NRD) from 2010–2014, and included patients who underwent craniotomy for brain metastasis, identified using ICD-9-CM diagnosis (198.3) and procedure (01.59) codes. The primary outcome of the study was unplanned 30-day all-cause readmission rate. Secondary outcomes included reasons and costs of readmissions. Hierarchical logistic regression model was used to identify the factors associated with 30-day readmission following craniotomy for brain metastasis. During the study period, 44,846 index hospitalizations occurred for patients who underwent resection of brain metastasis. In this cohort, 17.8% (n = 7,965) had unplanned readmissions within the first 30 days after discharge from the index hospitalization. The readmission rate did not change significantly during the five-year study period (p-trend = 0.286). The median per-patient cost for 30-day unplanned readmission was $11,109 and this amounted to a total of $26.4 million per year, which extrapolates to a national expenditure of $269.6 million. Increasing age, male sex, insurance status, Elixhauser comorbidity index, length of stay, teaching status of the hospital, neurological complications and infectious complications were associated with 30-day readmission following discharge after an index admission for craniotomy for brain metastasis. Unplanned readmission rates after resection of brain metastasis remain high and involve substantial healthcare expenditures. Developing tools and interventions to prevent avoidable readmissions could focus on the high-risk patients as a future strategy to decrease substantial healthcare expense.

The purpose of this study was to critically analyze the risk of unplanned readmission following resection of brain metastasis and to identify key risk factors to allow for early intervention strategies in high-risk patients. We analyzed data from the Nationwide Readmissions Database (NRD) from 2010-2014, and included patients who underwent craniotomy for brain metastasis, identified using ICD-9-CM diagnosis (198.3) and procedure (01.59) codes. The primary outcome of the study was unplanned 30-day all-cause readmission rate. Secondary outcomes included reasons and costs of readmissions. Hierarchical logistic regression model was used to identify the factors associated with 30-day readmission following craniotomy for brain metastasis. During the study period, 44,846 index hospitalizations occurred for patients who underwent resection of brain metastasis. In this cohort, 17.8% (n = 7,965) had unplanned readmissions within the first 30 days after discharge from the index hospitalization. The readmission rate did not change significantly during the five-year study period (p-trend = 0.286). The median per-patient cost for 30-day unplanned readmission was $11,109 and this amounted to a total of $26.4 million per year, which extrapolates to a national expenditure of $269.6 million. Increasing age, male sex, insurance status, Elixhauser comorbidity index, length of stay, teaching status of the hospital, neurological complications and infectious complications were associated with 30-day readmission following discharge after an index admission for craniotomy for brain metastasis. Unplanned readmission rates after resection of brain metastasis remain high and involve substantial healthcare expenditures. Developing tools and interventions to prevent avoidable readmissions could focus on the high-risk patients as a future strategy to decrease substantial healthcare expense.
Approximately 10-30% of cancer patients develop brain metastasis during the course of their systemic disease, resulting in over 200,000 cases diagnosed annually in the United States 1 . There are multiple indications for resection of brain metastasis, including lengthening survival in a subset of patients, providing a pathological diagnosis, relieving tumor-related mass effect, improving neurologic functional status, and optimizing multi-modal management of large brain metastasis 2 . Approximately 1 in 6 patients who undergo a craniotomy is readmitted within 30 days of their index surgical admission at an estimated cost of $20,296 per readmission 3 . There has been a substantial reduction in the rates of unplanned readmission following many extracranial surgeries, however, single-institution studies have demonstrated relatively stagnant trends in neurosurgery readmission rates 3 . Current estimates theorize that approximately 70% of all-cause readmissions are avoidable. By establishing the factors that make hospital readmissions preventable after neurosurgical procedures, risk management for craniotomies will improve patient care while mitigating the related financial cost of the hospital readmission care 4 .  5 . As a result of this program, hospitals are penalized for increased rates of risk-standardized 30-day readmissions for pre-determined conditions, such as acute myocardial infarction, total hip and knee arthroplasty, chronic obstructive pulmonary disorder, and heart failure, with other conditions likely added in the future. After the implementation of the HRRP program, hospital systems have implemented various measures to decrease readmissions rates. Studies performed after the introduction of HRRP show many targetable risk factors, such as surgical volume, postoperative complications, and hospital length of stay, significantly affected the readmission rate after surgeries 6,7 .
Substantial studies on factors associated with readmission rates after craniotomy are yet unpublished. Understanding these elements could help lower readmission rates, reduce healthcare costs, as well as improve the quality of life of brain metastasis patients. The objective of this study was to develop a risk model for predicting 30-day unplanned readmission rates after surgical treatment of brain metastasis.

Materials and methods
Data source and design. This was a cross-sectional analysis of data collected from the Nationwide Readmissions Database (NRD) from 2010 to 2014. The Agency for Healthcare Research and Quality (AHRQ) began NRD as a component of the Healthcare Cost and Utilization Project (HCUP). NRD is a publicly accessible all-payer inpatient database that reports approximately 49% of all US hospitalizations from 21 states 8,9 . NRD contains discharge data from all US community hospitals, excluding rehabilitation centers and acute long-term facilities.
Study population. We included data from all patients who underwent resection of brain metastasis. We identified patients undergoing craniotomies using ICD-9-CM diagnosis codes and the performed surgical procedures using ICD-9-CM procedure codes (Supplemental Table 1). We excluded patients who died during index hospitalizations, had planned readmissions, did not have information in discharge dispositions, or transferred to other acute care hospitals. We also excluded patients who were discharged in December due to the lack of 30-day follow-up data during the study period. Only first readmissions were included when patients experienced multiple readmissions within 30 days of discharge from the index hospitalization. Figure 1 shows the CONSORT diagram for participant inclusion in this study.  www.nature.com/scientificreports/ Patient and hospital characteristics and surgical procedures. For each initial hospitalization, the NRD includes information regarding numerous patient variables. Patient characteristics abstracted included age, sex, primary payor, median household income for patient's ZIP Code, Elixhauser comorbidity index, and length of stay. Hospital factors in NRD used in this study included hospital bed size, hospital teaching status (metropolitan and teaching vs. non-metropolitan), and hospital ownership.
Outcomes measures. For this study, the primary outcome was unplanned 30-day all-cause readmission rates. The study used methods described by HCUP in order to identify all readmissions and the methods delineated by Horwitz et al. for unplanned readmissions 10 . We adhered to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines for cohort studies while describing our findings 11 . The study was reviewed by the Miami Cancer Institute's Institutional Review Board, which exempted the study from institutional review board approval and waived the requirement for informed consent because it uses previously collected deidentified data stored in NIS. Informed consent was not required since this study involves an administrative database and does not contain any identifiable information that can be linked to any specific participant. All the methods adhered to relevant ethical guidelines for handling human data.
Statistical analysis. SAS, version 9.4 (Cary, NC) was used for statistical analyses. Complex survey weights and procedures were used for calculating national approximations. We used appropriate survey nature (SUR-VEYFREQ, SURVEYMEANS, and SURVEYGLIMMIX), weight (DISCWT), stratification (NRD_STRATUM), and clustering (HOSP_NRD) of the NRD to calculate national estimates. Baseline demographic, clinical, and hospital characteristics were compared between patients with and without unplanned 30-day readmissions. T-test and chi-square test were utilized for comparing continuous and categorical variables. We used hierarchical logistic regression model to identify the factors associated with 30-day readmission following craniotomy for brain metastasis since it accounts for the effect of nesting, where patient-level effects are nested with hospitallevel effects. In addition, hospital identification number was included as random effect, thus forming two level model 12 Table 1 shows the differences in demographic, hospital, and clinical characteristics for patients who did and did not experience unplanned readmissions within 30-days. The complications experienced during the index admission of patients undergoing resection for brain metastasis during the study period are shown in Table 2. The most common reason for readmission following craniotomy for brain metastasis was postoperative infection (5.6%), followed by convulsions (5.1%), intracerebral hemorrhage (4.5%), iatrogenic cerebrovascular infarction or hemorrhage (4.1%), and cerebral edema (2.4%) (Fig. 2). The total cost of unplanned 30-day readmissions following resection for brain metastasis was $132,096,474 during the study period, reflecting 49% of all national admissions data. Among the most common reasons for readmission, the costliest readmission was for postoperative infection ($22,534), followed by acute kidney failure ($15,919), iatrogenic cerebrovascular infarction or hemorrhage ($12,306), central nervous system complication ($12,040), and intracerebral hemorrhage ($11,626). Figure 2 illustrates the top 10 primary reasons for readmissions by percent volume and median hospitalization charge.
Factors associated with 30-day readmission identified by multivariable hierarchical logistic regression are shown in Table 3. Results of the regression analysis showed that increasing age, male sex, having Medicaid (compared to Medicare), having higher Elixhauser comorbidity index, longer length of stay, admission to metropolitan teaching (compared to metropolitan non-teaching hospital), having neurological and infectious complications were associated with higher risk for 30-day readmission following discharge after an index admission for craniotomy for brain metastasis, while self-pay (compared to Medicare) and admission to non-metropolitan hospital (compared to metropolitan non-teaching hospital) were associated with lower risk 30-day readmission.

Discussion
Quantifying the impact of readmissions after interventional or other procedures is an important part of quality improvement and assessment strategies. Prior studies using data from the Veterans Affairs Surgical Quality Improvement Program demonstrated that 30-day readmissions have trended downward in multiple surgical subspecialties, including neurosurgical procedures 13 . However, patients with brain metastasis represent a unique and understudied group of patients with additional challenges. Using a unique national data set, this study found that the 30-day rate of unplanned readmission following resection of a brain metastasis was approximately 17 www.nature.com/scientificreports/ and remained stagnant across the study period. The plateau in the rate of readmission is a major concern given the cost and morbidity impacts. To the best of our knowledge, this is the first study to look at unplanned readmissions for patients with brain metastases using a national data set. Identifying these risk factors and developing measures to prevent unplanned readmissions are key to reducing healthcare costs. We recognize that the data from AHRQ and HCUP have a lag between most recent available dataset to the current day. Though the postsurgical treatment and care paradigms have likely developed since 2014, there have been no recent studies or policy changes that have been implemented since that time period that would be expected to reduce the rate of readmissions appreciably beyond that described in the manuscript. Therefore, this highlights the importance of the work that, to the best of our knowledge, the readmission rate remained stagnant during the study period and would be expected to be representative of current day practice. Our study found eight risk factors associated with an increase in 30-day unplanned readmission following resection of brain metastasis, including age, sex, primary payer, hospital teaching status, Elixhauser comorbidity index, length of stay, infectious complications, and neurosurgical complications. Older age, insurance status, and presence of multiple comorbidities are key features associated with unplanned readmissions across different surgical series. For example, Caplan et al. demonstrated that in a single, multi-hospital, academic medical center, publicly insured supratentorial craniotomy patients were twice as likely to get readmitted as those with private insurance 14 . While we do not know for certain the mechanism as to why public insurance is significantly associated with an increased rate of readmission, it may in part be due to better and more sustainable access to health care facilities for patients with private insurance 15 . Medicaid and Medicare patients are also among the sicker and older patients with several comorbidities, which may result in recurrent hospitalizations regardless of the prior interventions 15 . Previous studies also demonstrated private insurance patients have lower in-hospital mortality and better discharge disposition 16 , while those on government sponsored insurance are more likely to get readmitted 3 . Particularly, Dohono et al. reported that two or more comorbidities increased the chance of readmission by 1.26 times 17 . Similarly, in the present study we found that patients with > 3 comorbidities had a significantly higher risk of readmission. We also found that length of stay of 5 days or more significantly increased the rate of readmission compared to patients with a length of stay < 5 days. Other series also demonstrated the association of hospital stay with risk of unplanned readmission, whether the extended stay is due to medical, surgical, or social issues 18 . Unlike previous studies that identified one or a few variables associated with risk of readmission, the study generated a novel model to stratify patients into risk categories. Taken together, patients in the "high" risk category (i.e., elderly patients with multiple comorbidities) may warrant extra measures to ensure appropriate discharge interventions are performed to prevent unplanned readmission.
Unplanned readmission after surgery is a key metric of interest as it correlates with a 30% increase in the risk of mortality and represents a significant healthcare burden to society 19 . In 2004, the Centers of Medicare and Medicaid Services reported that unplanned hospital readmissions totaled $17.4 billion in costs to Medicare system alone, leading to the institution of a 1% payment penalty for hospitals with excessive unplanned readmissions 20 . In this study, we found the most common and costly complication following 30-day readmission among patients undergoing craniotomy for brain metastasis was post-operative infection. Our analysis showed the cost for 30-day unplanned readmission for patients with brain metastasis was $26.4 million per year. Due to this substantial healthcare expenditure, factors associated with readmissions must be identified and targeted to decrease the financial burden.
Although the NRD was specifically designed to allow for readmission analysis, there are several limitations to this dataset and analyses. First, this is an administrative database and, therefore, limited in terms of the available clinical variables that then limits development of a comprehensive risk-prediction model. Future studies should include large datasets with increased patient-level granularity to further refine prediction models. Second, the  www.nature.com/scientificreports/ NRD links each admission to a state-specific identifier. Hence, a patient admitted to a state (index admission) for resection, but readmitted to another state for a complication is not be captured in this database. This would underestimate the rates of readmissions. However, we do assume that these underestimates are proportional in each of the risk categories.
In the United States, approximately 1 in 6 patients who undergoes craniotomy of a brain metastasis will experience an unplanned readmission within 30 days. Complications are not only common, but also costly. Therefore, hospital systems should consider the identified key risk factors associated with unplanned readmissions and develop strategies to risk-stratify patients and provide dedicated interventions to reduce the rates of readmission and improve the quality of care we deliver.