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Author Correction: Elexacaftor is a CFTR potentiator and acts synergistically with ivacaftor during acute and chronic treatment

The Original Article was published on 06 October 2021

Correction to: Scientific Reports https://doi.org/10.1038/s41598-021-99184-1, published online 06 October 2021


The original version of this Article contained an error in Figure 3 and 4 where the graph for panel C was omitted. The original Figures 3 and 4 and accompanying legends appear below.

Figure 3
figure 3

Synergism of ivacaftor (VX-770) and elexacaftor (VX-445) in potentiating G551D-CFTR in FRT cells. (A) Representative It recordings of FRT cells expressing human G551D-CFTR showing acute actions of VX-770 and VX-445. (B–C) Changes in It after acute addition of VX-770 in the absence and presence of VX-445 (B) and in response to the acute addition of VX-445 in the absence and presence of VX-770 (C). (D–E) Changes in It after the additions of test compounds for the experiment presented in (A). G551D-CFTR mediated It is greatest after acute potentiation by both VX-770 and VX-445. (F) Representative It recordings of FRT cells expressing human G551D-CFTR treated for 24 h with DMSO, VX-770, and/or VX-445. (G) Changes in It after the additions of test compounds for the experiment presented in (F). G551D-CFTR mediated It is greatest after chronic treatment by both VX-770 and VX-445. See SI for additional experimental details and for supporting data. All data are presented as mean ± standard error. Bars with different letters (A, B, C…) are significantly different from each other (ANOVA; P < 0.05). Asterisks indicate specific P values: ****P < 0.0001.

Figure 4
figure 4

Synergism of ivacaftor (VX-770) and elexacaftor (VX-445) in potentiating G551D-CFTR in HNE cells. (A) Representative It recordings of G551D-HNE cells showing acute actions of VX-770 and VX-445. (B–C) Changes in It after acute addition of VX-770 in the absence and presence of VX-445 (B) and in response to the acute addition of VX-445 in the absence and presence of VX-770 (C). (D–E) Changes in It after the additions of test compounds for the experiment presented in (A). G551D-CFTR mediated It is greatest after acute potentiation by both VX-770 and VX-445. (F) Representative It recordings of G551D-HNE treated for 24 h with DMSO, the double combination of VX-770 and VX-445, or the triple combination of VX-661, VX-770, and VX-445 (i.e., Trikafta). (G) CFTRinh-172 inhibited It for the experiment presented in (F). See SI for additional experimental details and for supporting data. All data are presented as mean ± standard error. Bars with different letters (A, B, C…) are significantly different from each other (ANOVA; P < 0.05). Asterisks indicate specific P values: ****P < 0.0001.


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Correspondence to Ciaran A. Shaughnessy.

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Shaughnessy, C.A., Zeitlin, P.L. & Bratcher, P.E. Author Correction: Elexacaftor is a CFTR potentiator and acts synergistically with ivacaftor during acute and chronic treatment. Sci Rep 11, 21295 (2021). https://doi.org/10.1038/s41598-021-00539-5

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