Table 2 Adverse events according to pirfenidone dose.

From: Efficacy of low dose pirfenidone in idiopathic pulmonary fibrosis: real world experience from a tertiary university hospital

  Total (n = 142) Low-dose (n = 79) High-dose (n = 63) P value
Dyspepsia 55 (38.7%) 38 (48.1%) 17 (27.0%) 0.017
Anorexia 36 (25.4%) 28 (35.4%) 8 (12.7%) 0.004
Rash 36 (25.4%) 23 (29.1%) 13 (20.6%) 0.337
Fatigue 23(16.2%) 11 (13.9%) 12 (19.0%) 0.552
Photosensitivity 16 (11.3%) 8 (10.1%) 8 (12.7%) 0.830
Nausea 15 (10.6%) 14 (17.7%) 1 (1.6%) 0.005
Dizziness 10 (7.0%) 7 (8.9%) 3 (4.8%) 0.536
Weight loss 8 (5.6%) 5 (6.3%) 3 (4.8%) 0.971
GERD 8 (5.6%) 4 (5.1%) 4 (6.3%) 1.000
Liver enzyme elevation 8 (5.6%) 5 (6.3%) 3 (4.8%) 0.971
Diarrhea 5 (3.5%) 1 (1.3%) 4 (6.3%) 0.240
Insomnia 7 (4.9%) 6 (7.6%) 1 (1.6%) 0.210
Headache 4 (2.8%) 2 (2.5%) 2 (3.2%) 1.000
Constipation 1(0.7%) 0 (0.0%) 1 (1.6%) 0.909
  1. Values are expressed as number (%).
  2. GERD gastroesophageal reflux disease.