Table 4 Multi-targeting drugs for SARS-CoV-2. The compounds are identified based on the binding free energies computed using AutoDock Vina for the three viral targets namely 3CLpro, PLpro and RdRp. The binding energies are in kcal/mol.

From: Searching for target-specific and multi-targeting organics for Covid-19 in the Drugbank database with a double scoring approach

Drug 3CLpro PLpro RdRp
DB04016 \(-\) 8.8 \(-\) 9.4 \(-\) 9.5
Phthalocyanine \(-\) 8.8 \(-\)9.6 \(-\) 10.6
DB08386 \(-\) 8.7 \(-\) 8.8 \(-\) 9.1
Tadalafil \(-\) 8.6 \(-\) 9.2 \(-\) 9.1
Lonafarnib \(-\) 8.5 \(-\) 8.5 \(-\) 9.1
Nilotinib \(-\) 8.4 \(-\) 8.7 \(-\) 9.1
Dihydroergotamine \(-\) 8.3 \(-\) 8.5 \(-\) 9.3
R-428 \(-\) 8.3 \(-\) 8.7 \(-\) 9.4