# Table 4 Multi-targeting drugs for SARS-CoV-2. The compounds are identified based on the binding free energies computed using AutoDock Vina for the three viral targets namely 3CLpro, PLpro and RdRp. The binding energies are in kcal/mol.

Drug 3CLpro PLpro RdRp
DB04016 $$-$$ 8.8 $$-$$ 9.4 $$-$$ 9.5
Phthalocyanine $$-$$ 8.8 $$-$$9.6 $$-$$ 10.6
DB08386 $$-$$ 8.7 $$-$$ 8.8 $$-$$ 9.1
Tadalafil $$-$$ 8.6 $$-$$ 9.2 $$-$$ 9.1
Lonafarnib $$-$$ 8.5 $$-$$ 8.5 $$-$$ 9.1
Nilotinib $$-$$ 8.4 $$-$$ 8.7 $$-$$ 9.1
Dihydroergotamine $$-$$ 8.3 $$-$$ 8.5 $$-$$ 9.3
R-428 $$-$$ 8.3 $$-$$ 8.7 $$-$$ 9.4