Functionality of HDL particles after adjustment for HDL-cholesterol. (a) The ability of HDL to promote [3H]-cholesterol efflux from macrophages and (b) the arylesterase activity of paraoxonase were adjusted for plasma HDL-cholesterol levels for the bedrest (n = 11) and the bedrest plus RVE (n = 11) groups. (a,b) Differences between pre-bedrest baseline and day 7 of bedrest, day 21 of bedrest and one day recovery, as well as differences between the two groups at each time point, were analyzed with RM one-way ANOVA using the Sidak’s multiple comparisons test (normally distributed data). Individual data are depicted on top of boxplots showing median and interquartile range, as well as minimum and maximum values (indicated by error bars). Significance level for the analyses was set to α = 0.05. No significant differences were observed between the two groups. Significant differences between the respective time points and the pre-bedrest baseline are indicated. HDL high-density lipoprotein, RVE resistive vibration exercise.