Figure 6 | Scientific Reports

Figure 6

From: Identifying metastasis-initiating miRNA-target regulations of colorectal cancer from expressional changes in primary tumors

Figure 6

(a) Enriched functions of cancer progression and metastasis in the target genes of the identified miRNA-target regulations and their p values of statistical significance. Among the 22 metastasis and cancer-related hallmark gene sets, eight are enriched. (b) Evaluated statistical significance of metastasis-relatedness of the identified miRNA-target regulations by random permutation test (1,000 random permutations of sample group labels). All 1,000 instances of identifying metastasis-initiating miRNA-target regulations from randomly permuted data sets show less metastasis-relatedness than that of the identified miRNA-target regulations from the original data set (equivalent to p value < 0.001).

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