Identified metastasis-initiating miRNA-target regulations. Up-regulated DEGs indicate that they have increased expression levels in primary tumor samples with metastasis, compared to primary tumors without metastasis, while down-regulated DEmiRNAs and DEGs have decreased expressions. All miRNAs are down-regulated, and they constitute the majority of the identified miRNA-target regulations with up-regulated target genes. Selected names of previously validated miRNAs and their target genes are shown. The network diagram was illustrated using Cytoscape 3.8 (https://cytoscape.org).