Figure 7 | Scientific Reports

Figure 7

From: The operational model of allosteric modulation of pharmacological agonism

Figure 7

Effects of an allosteric agonist that does not affect efficacy (β = 1) of an orthosteric agonist in producing a functional response. Effects of a pure negative (left) or positive (right) allosteric modulator on the functional response to an orthosteric agonist (top); observed half-efficient concentration EC'50 and observed maximal response E'MAX (middle); and dose ratio of half-efficient concentrations (bottom). EMAX = 1, τA = 3, τB = 1, values of factors of cooperativity α and β are indicated within the plots.

Back to article page